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H Iio
Osaka City University, Department of Material Science, Osaka-Japan
Chemical Engineering, Chemistry & Bioengineering Chemistry

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SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS Y Anita; M Hanafi; AMJ Putra; S Arifin; Y Usuki; H Iio
Indonesian Journal of Chemistry Vol 7, No 2 (2007)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.467 KB) | DOI: 10.22146/ijc.21701

Abstract

UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall yield was 87.10%.
Co-Authors AMJ Putra M Hanafi S Arifin Y Anita Y Usuki