SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS

Y Anita (LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314)
M Hanafi (LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314)
AMJ Putra (LIPI-Research Centre for Chemistry, Kawasan Puspiptek –Tangerang 15314)
S Arifin (Department of Chemistry, University of General Soedirman, Purwokerto, Indonesia)
Y Usuki (Osaka City University, Department of Material Science, Osaka-Japan)
H Iio (Osaka City University, Department of Material Science, Osaka-Japan)

Indonesian Journal of Chemistry
Vol 7, No 2 (2007)

UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall yield was 87.10%.