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Kurnia Firman
Unit Bidang Ilmu Farmasi Analisis, Departemen Farmasi, Institut Teknologi Bandung, Bandung
Chemical Engineering, Chemistry & Bioengineering Chemistry

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SIMULTANEOUS DETERMINATION OF PARACETAMOL AND IBUPROFENE MIXTURES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Sophi Damayanti; Slamet Ibrahim; Kurnia Firman; Daryono H Tjahjono
Indonesian Journal of Chemistry Vol 3, No 1 (2003)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.538 KB) | DOI: 10.22146/ijc.21899

Abstract

Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile - phosphate buffer pH = 4.5 (75:25) containing 0.075% sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73% and 102.02 ± 1.58%, respectively. The detector limits of the method was 1.30 and 1.60 μg/mL with the relative standard deviation (RSD) 0.74 and 1.52% for paracetamol and ibuprofen, respectively.
Co-Authors Daryono H Tjahjono Slamet Ibrahim Sophi Damayanti