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All Journal Meditory : The Journal of Medical Laboratory
IGA Dewi Sarihati
Poltekkes Denpasar Jurusan Analis Kesehatan
Biochemistry, Genetics & Molecular Biology Environmental Science

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MAKROFAG DAN ATEROSKLEROSIS IGA Dewi Sarihati
Meditory : The Journal of Medical Laboratory Vol 5, No 1 (2017): Juni 2017 Meditory
Publisher : Jurusan Analisis Kesehatan, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.268 KB) | DOI: 10.33992/m.v5i1.113

Abstract

Abstrak Inflamasi dalam aterogenesis terjadi oleh karena adanya interaksi antara leukosit, trombosit dan sel-sel dari dinding pembuluh darah. Rangsangan dari faktor risiko aterosklerosis yaitu hiperkolesterolemi akan meningkatkan produksi monosit di sumsum tulang . Monosit masuk ke arteria dan menempel pada sel endotel serta berubah jadi makrofag setelah sampai di ruang subendotel. LDL yang tinggi pada hiperkolerolemia akan mengakibatkan teradinya oksidasi LDL yang akan difagosit oleh makrofag sehingga berubah menjadi sel busa (foam cell) yang merupakan tahap awal dari aterogenesis. Peningkatan aktivitas dari makrofag M1 akan mendorong terjadinya aterogenesis sementara peningkatan aktivitas makrofag M2 akan mengakibatkan perbaikan dari lesi pada arteri. Untuk mengurangi terjadinya aterosklerosis adalah salah satunya dengan mencegah terjadinya inflamasi pada dindimg pembuluh darah karena hiperkolesterolemia. Kata Kunci: makrofag; aterosklerosis, inflamasi Abstract Inflammation in atherogenesis occurs because of the interaction between leukocytes, platelets and cells of the blood vessel wall. Stimulation of atherosclerosis risk factors as well as hypercholesterolemia will increase the production of monocytes in the bone marrow. Monocytes enter the arteria and attach to the endothelial cells and turn into macrophages after arriving at the subendotel space. High LDL in hypercholerolemia will result in the occurrence of LDL oxidation to be phagocytosed by macrophages and thus transform into foam cells that are the early stages of atherogenesis. Increased activity of M1 macrophages will promote atherogenesis while increased M2 macrophage activity will result in improvement of lesions in the arteries. To reduce the occurrence of atherosclerosis is one of them by preventing the occurrence of inflammation in the walls of blood vesselst due to hypercholesterolaemia. Keywords: macrophages; atherosclerosis, inflammation
GAMBARAN KADAR KALSIUM DARAH PADA WANITA MENOPAUSE DI BANJAR BINOH KAJA, DESA UBUNG KAJA, KECAMATAN DENPASAR UTARA IGA Dewi Sarihati
Meditory : The Journal of Medical Laboratory Vol 4, No 2 (2016): Desember 2016
Publisher : Jurusan Analisis Kesehatan, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.2 KB) | DOI: 10.33992/m.v4i2.58

Abstract

ABSTRACT Background: Menopause women are one of the groups that have a high risk of osteoporosis, because at that time the amount of estrogen is reduced so that the absorption of calcium from the digestive tract will be reduced about 20-25%. This is the reason why the level of calcium decreasing in blood. According to the initial observation at Banjar Binoh Kaja by researcher, from 10 menopause women, four of them are at risk of osteoporosis. Methode: This study is a descriptive study which describes the blood calcium levels in menopause women at Banjar Binoh Kaja, Ubung Kaja Village, North Denpasar District, by doing measurement on their blood calcium concentration with O – Cresolphthalein Complexon (OCPC) method. The 34 respondents taken from total population of menopause women in age range 50-65 years. Respondent was selected using purposive sampling with criteria: menopause women in age range 50-65 years and not undergoing hormone replacement therapy. .Result: The results showed that the average concentration of blood calcium is 8,83 mg/dL which 11.76% respondents had low levels of blood calcium and 88.24% respondents had normal blood calcium levels. 33,33% respondents in age range 62 – 65 years and 66,67% respondents in 16 – 20 years periods of menopause has decrement of blood calcium levels. Coclusion: The decrement of blood calcium levels mostly held in respondents in age range 62 – 65 years and respondents with 16-20 years periods of menopause. Keywords: blood calcium, menopause
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