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All Journal Majalah Kedokteran Andalas Health and Medical Journal Jurnal Ners Nusantara Hasana Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research
Lydia Susanti
Department Of Neurology, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Flipped Classroom Sebagai Strategi Pembelajaran Pada Era Digital Lydia Susanti; Dian Ayu Hamama Pitra
Health and Medical Journal Vol 1, No 2 (2019): HEME July 2019
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (846.231 KB) | DOI: 10.33854/heme.v1i2.242

Abstract

Latar belakang: Revolusi digital memiliki pengaruh penting di bidang pendidikan seperti pada bidang lainnya. Pengaruh ini juga menyebabkan perubahan radikal di bidang pendidikan, seperti dalam hal pendekatan pengajaran dan pembelajaran. Flipped classroom merupakan suatu strategi pembelajaran yang tergolong baru. Strategi pembelajaran ini semakin berkembang dengan kemajuan teknologi, seperti akses internet serta software yang pendukung lainnya. Pada pembelajaran tradisional pendidik menyampaikan materi, lalu untuk menambah pemahaman materi tersebut maka siswa akan mengerjakan tugas di sekolah dan diberikan pekerjaan rumah.  Pada flipped classroom, peserta didik berpartisipasi dalam mempersiapkan pembelajaran melalui tontonan video, memahami powerpoint dan mengakses sumber belajar yang disediakan oleh pendidik baik melalui media online seperti e-learning. Beberapa penelitian membuktikan bahwa penerapan Flipped classroom dapat meningkatkan motivasi belajar peserta didik. Tujuan: Tujuan: Untuk meninjau secara singkat semua informasi terkini tentang flipped classroom di era digital. Kesimpulan: Revolusi digital memiliki pengaruh penting di bidang pendidikan seperti di banyak bidang lainnya. Pengaruh ini juga menyebabkan perubahan radikal di bidang pendidikan, seperti dalam hal pendekatan pengajaran dan pembelajaran, sehingga pendidik perlu menciptakan  bentuk pembelajaran aktif yang sesuai dengan karakteristik peserta didik zaman ini.
Ischemic Stroke In infant With Tetralogy of Fallot Dian Ayu Hamama Pitra; Lydia Susanti
Health and Medical Journal Vol 1, No 1 (2019): HEME January 2019
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.13 KB) | DOI: 10.33854/heme.v1i1.221

Abstract

Objectives: Although stroke is often viewed as occurring primarily in the elderly, it also strikes infants, children, young adults. Stroke in children are rare but increasingly important conditions due to the severity of their complications and diverse diagnostic differentials. It is not yet clearly understood and with multifactorial etiologies. When it comes to stroke, children are not just little adults. Stroke risk factors, symptoms, prevention efforts, and treatment are often different in children than in adults. Up to 80 % of children with ischemic stroke have cardiovascular disease. Case report: RS, An infant, aged two and half years old was admitted to DR. M. Djamil hospital Padang, with right hemiplegy and developed aphasia after activity. One year ago, he had history of cyanotic skin but neglected by his parents and never sought medical treatment. Physical findings on this patient are cyanosis and clubbing fingers. Cardiac auscultation revealed a pansystolic murmur grade III-IV best heard at the upper left sternal border. Chest radiograph showed a characteristic “bootshaped” heart, which is a reflection of Right Ventricular (RV) hypertrophy. The ECG showed right axis deviation. Brain CT Scan revealed a large hypodense lesion on the left cerebral hemisphere suggested as large brain infarction. Echocardiogram revealed tetralogy of fallot with a larged malaligned ventricular septal defect (VSD) with 60 % aortic override. Patient was managed conservatively. After two weeks of admission, patient was discharged with improvement.Conclusion : Ischemic stroke in this infant with tetralogy of fallot occurred via paradoxical embolism mechanism.
Tatalaksana terkini pada miastenia gravis Lydia Susanti
Majalah Kedokteran Andalas Vol 45, No 4 (2022): Online October 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i4.p564-574.2022

Abstract

Myasthenia gravis (MG) is a disorder of the neuromuscular junction that causes fluctuating muscle weakness. The etiology of this disease is due to the presence of antibodies that attack acetylcholine receptors on the postsynaptic membrane (autoimmune). Myasthenia gravis is a chronic disease and most MG patients fall into Generalized Myasthenia Gravis (gMG) within 2 years of onset. Myasthenic crisis is a serious condition and requires high-cost management. Therefore, disease management continues to be updated to reduce mortality and mortality, as well as improve quality of life. This article discusses the latest myasthenia gravis; guidelines 2020 ; immunosuppressants; plasmaparesis; ivig
SINDROM MILLER FISHER SEBAGAI VARIAN SINDROM GUILLAN BARRE : LAPORAN KASUS Lydia Susanti; Fadrian Herjunio
Nusantara Hasana Journal Vol. 2 No. 12 (2023): Nusantara Hasana Journal, May 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v2i12.973

Abstract

Miller Fisher syndrome (MFS) is a rare variant of Guillan Barre Syndrome (GBS), with clinical symptoms of ophthalmoplegia, ataxia, areflexia. The diagnosis of MFS in this patient is based on a clear history supported by supporting examinations such as electrophysiological examination and CSF analysis. CSF analysis is often unsupportive at the onset of the disease, in which case the validated Brighton criteria may serve as a reference for establishing the diagnosis of GBS and its variants.
The Relationship between Plasma Glutamate Levels and Sleep Quality in HIV Patients Dhiang Mulia Syofiadi; Yuliarni Syafrita; Lydia Susanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 11 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i11.884

Abstract

Background: Disturbance sleep quality is often found in sufferers of human immunodeficiency virus (HIV). Disturbed sleep quality can affect immunity, which ultimately can increase patient morbidity and mortality. Impaired sleep quality in HIV sufferers is related to neurotoxicity due to the HIV virus, which damages sleep architecture. HIV infection can cause an increase in brain extracellular glutamate. Elevated glutamate plays a role in neuronal and glial damage and death. This study aimed to assess the relationship between plasma glutamate levels and sleep quality in HIV sufferers. Methods: The research uses a cross-sectional design. The samples were HIV sufferers in a polyclinic voluntary counseling test (VCT) internal medicine of Dr. M. Djamil General Hospital Padang, who met the inclusion and exclusion criteria. Samples are selected by consecutive methods. Sleep quality was assessed using a questionnaire called the Pittsburgh sleep quality index (PSQI). Plasma glutamate levels were measured using the ELISA method. Statistical analysis using SPSS with a p-value <0.05 was considered statistically significant. Results: The research sample consisted of 82 people. The median plasma glutamate level was 16.39 µg/mL. Impaired sleep quality was found in 45 (54.9%) HIV sufferers. There was no significant relationship between plasma glutamate levels (p= 0.506), age (p=0.795), gender (p=0.547), education (p=0.358), occupation (p=0.255), disease duration (p=0.348), stage (p=0.309) and type of ARV therapy (p=0.791) with sleep quality in HIV sufferers. From this research, a significant relationship was found between sleep quality, body mass index (BMI) (p= 0.015), and marital status (p= 0.039). Conclusion: There is no relationship between plasma glutamate levels and sleep quality in HIV sufferers. There are other factors that influence sleep quality, namely BMI and marital status.
The Relationship Between Serum Calprotectin Levels and Severity in Myasthenia Gravis Patients at Dr. M. Djamil Hospital Padang Novia Riza Lestari; Lydia Susanti; Yuliarni Syafrita; Restu Susanti; Reno Bestari; Dedi Sutia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51684

Abstract

Myasthenia Gravis (MG) is an autoimmune disorder characterized by skeletal muscle weakness resulting from impaired neuromuscular transmission, primarily caused by autoantibodies directed against acetylcholine receptors. Excessive immune activation in MG triggers the release of inflammatory mediators, one of which is calprotectin — a protein complex of S100A8/A9 that is released by neutrophils and monocytes during the inflammatory process. Elevated levels of calprotectin have been reported in various autoimmune diseases; however, the relationship between serum calprotectin concentration and disease severity in MG, based on the Myasthenia Gravis Foundation of America (MGFA) classification, has not been extensively investigated. The objective of this study was to determine the association between serum calprotectin levels and disease severity in patients with MG. This study employed a cross-sectional design involving 23 MG patients receiving treatment at Dr. M. Djamil Hospital, Padang, from May to July 2025. Serum calprotectin levels were measured using the ELISA method, while MG severity was assessed using the MGFA scoring system. Statistical analyses were performed using SPSS version 27.0, with a significance level set at p < 0.05. The results of this study showed that serum calprotectin levels in patients with Myasthenia Gravis (MG) tended to be higher than in the healthy population; however, there was no significant association with the Myasthenia Gravis Foundation of America (MGFA) severity classification (p = 0.276).
Hubungan Kadar Glial Fibrillary Acidic Protein Serum dengan Skor Nihss dan Ich Score pada Pasien Stroke Hemoragik Dicky Lesmana; Syarif Indra; Restu Susanti; Yuliarni Syafrita; Dedi Sutia; Lydia Susanti
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54075

Abstract

Hemorrhagic stroke, particularly intracerebral hemorrhage (ICH), is a major cause of mortality and morbidity and is associated with poorer outcomes than ischemic stroke. The severity of ICH is commonly assessed using the National Institutes of Health Stroke Scale (NIHSS) and the ICH score. Glial fibrillary acidic protein (GFAP) is an astrocytic protein released into the circulation as a result of glial tissue injury and is known to be elevated in various types of stroke, with generally higher concentrations in ICH. This study aimed to evaluate the potential of GFAP as an indicator of disease severity and clinical outcomes in ICH. This was an observational analytic study with a cross-sectional design conducted in patients with hemorrhagic stroke hospitalized at RSUP Dr. M. Djamil Padang from February to July 2025. Serum GFAP levels were measured using the ELISA method, while disease severity and mortality were assessed using the NIHSS and ICH score. Statistical analysis was performed using one-way ANOVA or the Kruskal–Wallis test to examine the relationship between GFAP and NIHSS, and Pearson or Spearman correlation tests to evaluate the relationship between GFAP and the ICH score. Most subjects had moderate stroke severity based on the NIHSS (48.57%). The median serum GFAP level was 3.41 ng/mL (1.75–17.7). Analysis showed a significant difference in GFAP levels across the three NIHSS severity categories (p = 0.001), particularly between the mild–severe (p = 0.002) and moderate–severe (p = 0.001) groups. Spearman correlation analysis demonstrated a significant positive correlation between GFAP levels and the ICH score (p = 0.000; r = 0.481). In addition, GFAP levels were significantly higher in patients with hemorrhage volumes >30 cc compared with those ≤30 cc (median 7.29 vs 3.24 ng/mL; p = 0.000). Serum GFAP levels were significantly associated with NIHSS score, ICH score, and hemorrhage volume in patients with hemorrhagic stroke. These findings support the use of GFAP as a biomarker for assessing severity and prognosis in hemorrhagic stroke.
Co-Authors Dedi Sutia Dhiang Mulia Syofiadi Dian Ayu Hamama Pitra Dicky Lesmana Fadrian Herjunio Novia Riza Lestari Reno Bestari Restu Susanti Syarif Indra Yuliarni Syafrita