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All Journal Jurnal Kesehatan Saintika Meditory Indonesian Journal of Global Health Research
Yanwirasti Yanwirasti
Universitas Andalas
Health Professions Medicine & Pharmacology Nursing Public Health

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PENGARUH LAMA PEMAKAIAN KONTRASEPSI DEPOMEDROXY PROGESTERON ASETAT TERHADAP KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA Dewi Fransisca; Yanwirasti Yanwirasti; Eliza Anas
Jurnal Kesehatan Saintika Meditory Vol 4, No 1 (2021): Mei 2021
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v4i1.1041

Abstract

Depo Medroxyprogesteron Acetate (DMPA) merupakan turunan dari progesteron, berbentuk suspensi cair yang diberikan secara intramuskular setiap 12 minggu area bokong. DMPA memiliki beberapa efek samping diantaranya perubahan metabolisme lipid serum pada penggunaan jangka panjang. Penelitian ini bertujuan untuk mempelajari pengaruh lama penggunaan depo medroxyprogesterone acetate terhadap kadar kolesterol total dan trigliserida. Penelitian dilaksanakan di Puskesmas Lubuk Buaya dan Laboratorium Biokimia Fakultas Kedokteran Universitas Andalas Padang. Jenis penelitian adalah penelitian observasional dengan rancangan cross sectional. Sampel dikelompokkan menjadi dua, akseptor menggunakan DMPA kurang dan lebih dari 3 tahun. Enam belas responden diambil untuk setiap kelompok dengan menggunakan teknik consecutive sampling. Pengambilan darah responden dilakukan secara intravena dan diukur dengan Metode Enzimatis Kolorimetri (CHOD-PAP) untuk mengetahui kolesterol total dan trigliserida (GPO-PAP). Kolesterol total rata-rata akseptor kurang dari tiga tahun adalah 185,46 ± 16,76 mg / dl dan yang lebih dari tiga tahun adalah 196,23 ± 35,55 mg / dl. Rata-rata trigliserida akseptor kurang dari tiga tahun adalah144,85 ± 23,82 yang lebih dari tiga tahun164,46 ± 34,54 mg / dl. Kadar kolesterol total dan trigliserida kedua kelompok tidak berbeda nyata
The Effectiveness of Probiotic Administration as A Novel Therapeutic Target for Hypertension During Pregnancy Induced by Primary and Secondary Factors: A Systematic Literature Review of Preclinical Studies Budi Budi; Nur Indrawaty Lipoeto; Yanwirasti Yanwirasti; Donel Suheimi
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.307

Abstract

Hypertension during pregnancy, including preeclampsia, remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. The complex pathogenesis of pregnancy-related hypertension involves endothelial dysfunction, impaired angiogenesis, oxidative stress, and immune dysregulation. Conventional pharmacological therapies continue to face limitations in terms of efficacy and safety for pregnant women. Therefore, there is an urgent need for safer and more effective molecular-based therapeutic alternatives, one of which is the use of probiotics. The aim of this systematic review is to analyse the potential effectiveness of probiotic administration as a novel therapeutic target for pregnancy-induced hypertension driven by primary and secondary factors. This systematic review was conducted following the PRISMA guidelines. A comprehensive literature search was performed across databases including Google Scholar, PubMed, Taylor & Francis, and ScienceDirect, covering publications from 2015 to 2025. Inclusion criteria were applied based on the PICOS framework. A total of 14 preclinical in vivo studies met the inclusion criteria. Probiotics such as Akkermansia muciniphila, Bifidobacterium bifidum, Lactobacillus spp., Limosilactobacillus spp., and Lactiplantibacillus plantarum demonstrated significant effectiveness in reducing systolic and diastolic blood pressure, improving endothelial function, suppressing inflammation, and mitigating oxidative stress. These effects were mediated through mechanisms involving gut microbiota modulation and regulation of the renin-angiotensin system. Probiotics hold promise as a safe and effective alternative therapy for reducing hypertension during pregnancy and may support the development of future non-pharmacological, microbiota-based therapeutic strategies.
Co-Authors Budi Budi Dewi Fransisca Donel Suheimi Eliza Anas Nur Indrawaty Lipoeto