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All Journal Jurnal Ners Indonesian Journal of Global Health Research
Donel Suheimi
Universitas Riau
Health Professions Medicine & Pharmacology Nursing

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Peran Mekanisme Apoptosis dan Autophagy Pada Ketuban Pecah Dini: Tinjauan Sistematis Studi Klinis dan Pre-Klinis Arvan Syahruddin; Aisyah Elliyanti; Donel Suheimi; Mohamad Reza
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54125

Abstract

Ketuban Pecah Dini (KPD) merupakan kondisi obstetri multifaktorial yang berkontribusi signifikan terhadap persalinan prematur dan morbiditas neonatal. Bukti terbaru menunjukkan bahwa disregulasi apoptosis dan autophagy berperan penting dalam melemahnya integritas membran ketuban. Tujuan tinjauan sistematis  ini bertujuan untuk menganalisis peran jalur apoptosis dan autophagy dalam patogenesis KPD berdasarkan temuan studi klinis dan pre-klinis. Metode tinjauan sistematis dilakukan  mengikuti pedoman PRISMA dengan pencarian pada database Google Scholar, PubMed, Taylor & Francis, dan Science Direct untuk publikasi tahun 2015–2025. Seleksi artikel menggunakan kriteria PICOS, dengan fokus pada faktor biomolekuler apoptosis dan autophagy pada KPD. Jenis studi dengan temuan: 9 studi klinis dan 6 pre-klinis. Jumlah sampel 254 dengan riwayat partus KPD dan 295 dengan riwayat partus normal. Hasil sebanyak 10 studi memenuhi kriteria inklusi. KPD ditandai oleh peningkatan mediator apoptosis seperti caspase-3, caspase-8, BAX, dan AIF, disertai penurunan BCL-2. Di sisi lain, terjadi penurunan ekspresi regulator autophagy utama seperti Beclin-1, ULK1, ATG5, dan ATG7, yang menunjukkan gangguan aliran autophagy protektif. Interaksi antara inflamasi, stres oksidatif, dan disfungsi metabolik memperkuat aktivasi apoptosis dan kegagalan autophagy. Kesimpulan disregulasi keseimbangan apoptosis dan autophagy berperan sentral dalam patogenesis KPD dan berpotensi menjadi target diagnostik serta terapeutik di masa mendatang.
The Effectiveness of Probiotic Administration as A Novel Therapeutic Target for Hypertension During Pregnancy Induced by Primary and Secondary Factors: A Systematic Literature Review of Preclinical Studies Budi Budi; Nur Indrawaty Lipoeto; Yanwirasti Yanwirasti; Donel Suheimi
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.307

Abstract

Hypertension during pregnancy, including preeclampsia, remains one of the leading causes of maternal and perinatal morbidity and mortality worldwide. The complex pathogenesis of pregnancy-related hypertension involves endothelial dysfunction, impaired angiogenesis, oxidative stress, and immune dysregulation. Conventional pharmacological therapies continue to face limitations in terms of efficacy and safety for pregnant women. Therefore, there is an urgent need for safer and more effective molecular-based therapeutic alternatives, one of which is the use of probiotics. The aim of this systematic review is to analyse the potential effectiveness of probiotic administration as a novel therapeutic target for pregnancy-induced hypertension driven by primary and secondary factors. This systematic review was conducted following the PRISMA guidelines. A comprehensive literature search was performed across databases including Google Scholar, PubMed, Taylor & Francis, and ScienceDirect, covering publications from 2015 to 2025. Inclusion criteria were applied based on the PICOS framework. A total of 14 preclinical in vivo studies met the inclusion criteria. Probiotics such as Akkermansia muciniphila, Bifidobacterium bifidum, Lactobacillus spp., Limosilactobacillus spp., and Lactiplantibacillus plantarum demonstrated significant effectiveness in reducing systolic and diastolic blood pressure, improving endothelial function, suppressing inflammation, and mitigating oxidative stress. These effects were mediated through mechanisms involving gut microbiota modulation and regulation of the renin-angiotensin system. Probiotics hold promise as a safe and effective alternative therapy for reducing hypertension during pregnancy and may support the development of future non-pharmacological, microbiota-based therapeutic strategies.
Co-Authors Aisyah Elliyanti Arvan Syahruddin Budi Budi Mohamad Reza Nur Indrawaty Lipoeto Yanwirasti Yanwirasti