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All Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Telly Tessy
Faculty of Medicine University of Hasanuddin Makassar
Health Professions Medicine & Pharmacology Public Health

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The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients Baharuddin, NurIedil; Abdullah, Nusratuddin; Tessy, Telly; Chalid, St Maisuri T; Chalid, St Maisuri T
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.499 KB) | DOI: 10.32771/inajog.v6i2.770

Abstract

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]Keywords: endometriosis, matrix metalloproteinase-2, MMP-2
Lidocaine Prilocaine Cream versus LidocaineHCL Injection for Pain Relief during Second Degree of Perineal Tear Suturing after Vaginal Delivery: A Comparative Study Rahmawati, Rahmawati; Lotisna, David; Abdullah, Nusratuddin; Chalid, Maisuri T; Tessy, Telly
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.379 KB) | DOI: 10.32771/inajog.v6i4.846

Abstract

Abstract Objective : To compare the effectiveness of topically applied lidocaine-prilocaine cream with lidocaine-HCl injection in the reduction of pain during second degree of perineal tear suturing after vaginal delivery. Methods : One hundred and twenty-four of women with second degree of perineal tear after vaginal delivery were enrolled in this randomized clinical trial. Women were assigned randomly to have either application of lidocaine-prilocaine cream (n=62) or local injection of lidocaine-HCl (n=62) for anesthetic during perineal suturing. Pain measured with viasual analog scale (VAS) for the first 5 minutes during the perineal suturing. Statistical analysis was performed by comparative analytic numerical unpaired with independent t test between the two groups and significance was assessed at p<0.05. Data were presented as mean ± standard deviation (SD). Results : There was no significantly different of pain score between lidocaine-prilocaine cream and lidocaine-HCl injection group (5.66±1.07 vs 5.56±1.5; p=0.473). Conclusion : Application of lidocaine-prolicaine cream as effective as injection of lidocaine for reducing pain during second degree of perineal tear suturing after vaginal delivery. Keywords : Lidocaine-prilocaine cream, lidocaine-HCl injection, pain, perineal suturing, vaginal delivery     Abstrak Tujuan: Untuk membandingkan efektivitas antara lidokain-prilokain topikal dan lidokain-HCl injeksi dalam mengurangi nyeri selama penjahitan luka perineum tingkat dua setelah persalinan normal. Metode: Seratus dua puluh empat perempuan dengan robekan perineum tingkat dua postpartum pervaginam mengikuti uji coba klinis secara acak ini. Enam puluh dua perempuan (n=62) menggunakan lidokain-prilokain topikal dan 62 perempuan lainnya (n=62) menggunakan injeksi lokal lidokain-HCl untuk anestesi selama penjahitan perineum. Nyeri diukur dengan visual analog scale (VAS) untuk 5 menit pertama selama penjahitan perineum. Analisis statistik dilakukan dengan uji numerik komparatif tidak berpasangan dengan uji t independen antara kedua kelompok dengan tingkat kemaknaan p<0,05. Data disajikan sebagai rerata ± standar deviasi (SD). Hasil: Tidak terdapat perbedaan signifikan skor nyeri antara kelompok  lidokain-prilokain topikal dan kelompok injeksi lidokain-HCl (5,66 ± 1,07 vs 5,56 ± 1,5; p = 0,473). Kesimpulan : Efektifitas lidokain-prolikain topikal untuk mengurangi nyeri sama dengan injeksi lidokain-HCl selama penjahitan robekan perineum tingkat dua postpartum pervaginam. Kata kunci : Lidokain-prolikain topical, lidokain-HCl injeksi, nyeri, penjahitan perineum, persalinan normal
AntiMüllerian Hormone Level in Laparoscopic Cystectomy Budipramana, Edwin; Abdullah, Nusratuddin; Tessy, Telly
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.084 KB) | DOI: 10.32771/inajog.v4i4.449

Abstract

Objective: To evaluate the impact of laparoscopic cystectomy using cautery and suturing technique on the ovarian reserve represented by the level of Anti-Müllerian Hormone (AMH) serum. Method: This used prospective cohort study design conducted in Dr. Wahidin Sudirohusodo Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Hasanuddin, Makassar, from November 2014 to October 2015. We got total samples of 60 subjects divided into cautery and suturing group. Anti-Mullerian hormone serum test was examined on all subjects pre and post laparoscopic cystectomy. Result: The result indicated a significant decrease of AMH level undergoing laparoscopic cystectomy both cautery and suturing technique; whereas, more dominant results were showed in the cautery group (p0.05). Conclusion: The decline in the number of ovarian reserve as described by the reduction of AMH level occurs significantly in both cauterization and suturing technique, which are more dominant reduction in the cauterization group. [Indones J Obstet Gynecol 2016; 4-4: 203-207] Keywords: Anti-Müllerian Hormone, laparoscopic cystectomy, ovarian reserve
AntiMüllerian Hormone Level in Laparoscopic Cystectomy Budipramana, Edwin; Abdullah, Nusratuddin; Tessy, Telly
Indonesian Journal of Obstetrics and Gynecology Volume 4, No. 4, October 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (93.084 KB) | DOI: 10.32771/inajog.v4i4.449

Abstract

Objective: To evaluate the impact of laparoscopic cystectomy using cautery and suturing technique on the ovarian reserve represented by the level of Anti-Müllerian Hormone (AMH) serum. Method: This used prospective cohort study design conducted in Dr. Wahidin Sudirohusodo Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Hasanuddin, Makassar, from November 2014 to October 2015. We got total samples of 60 subjects divided into cautery and suturing group. Anti-Mullerian hormone serum test was examined on all subjects pre and post laparoscopic cystectomy. Result: The result indicated a significant decrease of AMH level undergoing laparoscopic cystectomy both cautery and suturing technique; whereas, more dominant results were showed in the cautery group (p0.05). Conclusion: The decline in the number of ovarian reserve as described by the reduction of AMH level occurs significantly in both cauterization and suturing technique, which are more dominant reduction in the cauterization group. [Indones J Obstet Gynecol 2016; 4-4: 203-207] Keywords: Anti-Müllerian Hormone, laparoscopic cystectomy, ovarian reserve
The Role of Matrix Metalloproteinase2 (MMP2) in Serum and Peritoneal Fluid of Endometriotic Patients Baharuddin, NurIedil; Abdullah, Nusratuddin; Tessy, Telly; Chalid, St Maisuri T; Chalid, St Maisuri T
Indonesian Journal of Obstetrics and Gynecology Volume 6. No. 2 April 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.499 KB) | DOI: 10.32771/inajog.v6i2.770

Abstract

Objective: To determine the role of matrix metalloproteinase-2(MMP-2) in serum and peritoneal fluid of endometrioticpatients.Methods: Research’s design using cross-sectional method in Dr.Wahidin Sudirohusodo hospital and several other hospitals inMakassar within May 2015 until May 2016. Subjects were chosenusing consecutive sampling technique. The examination usingthe ELISA method. The data were analysed using Fisher exact,t-independent, Mann-Whitney, and Spearman association.Results: A total of 50 subjects were recruited in this study. Mostlythe value of MMP-2 serum and peritoneal fluid in endometriosisgroup was higher compare to study control. There was significantdifferent between the total of MMP-2 serum and peritoneal fluid.There was also a significant association between the value ofMMP-2 serum and peritoneal fluid with endometriosis.Conclusion: The value of MMP-2 serum and peritoneal fluid werehigher in endometriotic patients compared to those withoutendometriosis. The higher the value of MMP-2 serum andperitoneal fluid, the higher the stage of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 104-109]Keywords: endometriosis, matrix metalloproteinase-2, MMP-2
Lidocaine Prilocaine Cream versus LidocaineHCL Injection for Pain Relief during Second Degree of Perineal Tear Suturing after Vaginal Delivery: A Comparative Study Rahmawati, Rahmawati; Lotisna, David; Abdullah, Nusratuddin; Chalid, Maisuri T; Tessy, Telly
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 4 October 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (84.379 KB) | DOI: 10.32771/inajog.v6i4.846

Abstract

Abstract Objective : To compare the effectiveness of topically applied lidocaine-prilocaine cream with lidocaine-HCl injection in the reduction of pain during second degree of perineal tear suturing after vaginal delivery. Methods : One hundred and twenty-four of women with second degree of perineal tear after vaginal delivery were enrolled in this randomized clinical trial. Women were assigned randomly to have either application of lidocaine-prilocaine cream (n=62) or local injection of lidocaine-HCl (n=62) for anesthetic during perineal suturing. Pain measured with viasual analog scale (VAS) for the first 5 minutes during the perineal suturing. Statistical analysis was performed by comparative analytic numerical unpaired with independent t test between the two groups and significance was assessed at p<0.05. Data were presented as mean ± standard deviation (SD). Results : There was no significantly different of pain score between lidocaine-prilocaine cream and lidocaine-HCl injection group (5.66±1.07 vs 5.56±1.5; p=0.473). Conclusion : Application of lidocaine-prolicaine cream as effective as injection of lidocaine for reducing pain during second degree of perineal tear suturing after vaginal delivery. Keywords : Lidocaine-prilocaine cream, lidocaine-HCl injection, pain, perineal suturing, vaginal delivery     Abstrak Tujuan: Untuk membandingkan efektivitas antara lidokain-prilokain topikal dan lidokain-HCl injeksi dalam mengurangi nyeri selama penjahitan luka perineum tingkat dua setelah persalinan normal. Metode: Seratus dua puluh empat perempuan dengan robekan perineum tingkat dua postpartum pervaginam mengikuti uji coba klinis secara acak ini. Enam puluh dua perempuan (n=62) menggunakan lidokain-prilokain topikal dan 62 perempuan lainnya (n=62) menggunakan injeksi lokal lidokain-HCl untuk anestesi selama penjahitan perineum. Nyeri diukur dengan visual analog scale (VAS) untuk 5 menit pertama selama penjahitan perineum. Analisis statistik dilakukan dengan uji numerik komparatif tidak berpasangan dengan uji t independen antara kedua kelompok dengan tingkat kemaknaan p<0,05. Data disajikan sebagai rerata ± standar deviasi (SD). Hasil: Tidak terdapat perbedaan signifikan skor nyeri antara kelompok  lidokain-prilokain topikal dan kelompok injeksi lidokain-HCl (5,66 ± 1,07 vs 5,56 ± 1,5; p = 0,473). Kesimpulan : Efektifitas lidokain-prolikain topikal untuk mengurangi nyeri sama dengan injeksi lidokain-HCl selama penjahitan robekan perineum tingkat dua postpartum pervaginam. Kata kunci : Lidokain-prolikain topical, lidokain-HCl injeksi, nyeri, penjahitan perineum, persalinan normal
Association between Serum Cotinine Levels, Fetal Biometry, and Umbilical Artery Flow in Pregnant Women Exposed to Secondhand Smoke Diana, Margaret; Riu, Deviana Soraya; Madya, Fatmawati; Chalid, St. Maisuri T.; AM, Nasrudin; Tessy, Telly
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 3 November 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i3.956

Abstract

Objective: This study aimed to investigate the impact of SHS exposure on fetal biometry and umbilical artery flow at 24 – 28 weeks of gestation.Methods: This cross-sectional study included 110 pregnant women, divided into a study group (55 passive) smokers and a control group (55 non-passive smokers). Serum cotinine levels were measured using ELISA. Fetal biometry (biparietal diameter, head circumference, abdominal circumference, and femur length) and umbilical artery flow (pulsatility and resistance indices) were assessed via ultrasound and Doppler ultrasonography. Group comparisons were conducted using Chi-square and independent t-tests.Results: The passive smoker group had significantly higher mean serum cotinine levels compared with the control group (10.97 ng/mL vs. 4.53 ng/mL; p = 0.01). However, no statistically significant differences (p > 0.05) were found in any of the fetal biometric parameters or umbilical artery flow indices between the groups. Correlation analyses also showed no significant association between cotinine levels and the measured fetal outcomes.Conclusion: In this second-trimester study, SHS exposure, confirmed by elevated cotinine levels, was not associated with measurable adverse effects on fetal biometry or umbilical artery flow. These non-significant findings underscore the need for longitudinal research to evaluate the cumulative impact of SHS, particularly in the third trimester and on final birth outcomes.Hubungan antara Kadar Kotinin Serum, Biometri Janin, dan Aliran Arteri Umbilikalis pada Ibu Hamil yang Terpapar Asap Rokok PasifAbstrakTujuan: Penelitian ini bertujuan untuk menelaah dampak paparan asap rokok pasif terhadap biometri janin dan aliran arteri umbilikalis pada usia kehamilan 24 – 28 minggu.Metode: Penelitian potong lintang ini melibatkan 110 ibu hamil yang dibagi menjadi kelompok studi (55 perokok pasif) dan kelompok kontrol (55 bukan perokok pasif). Kadar kotinin serum diukur menggunakan metode ELISA. Biometri janin (meliputi diameter biparietal, lingkar kepala, lingkar perut, dan panjang femur) serta aliran arteri umbilikalis (indeks pulsasi dan indeks resistensi) dinilai melalui ultrasonografi (USG) dan USG Doppler. Perbandingan antarkelompok dianalisis menggunakan uji Chi-square dan uji t independen.Hasil: Kelompok perokok pasif memiliki rerata kadar kotinin serum yang secara signifikan lebih tinggi dibandingkan kelompok kontrol (10,97 ng/mL vs. 4,53 ng/mL; p = 0,01). Namun, tidak ditemukan perbedaan bermakna secara statistik (p > 0,05) pada parameter biometri janin maupun indeks aliran arteri umbilikalis antara kedua kelompok. Analisis korelasi juga tidak menunjukkan adanya hubungan bermakna antara kadar kotinin dengan luaran janin yang diukur.Kesimpulan: Pada penelitian trimester kedua ini, paparan asap rokok pasif yang dikonfirmasi dengan peningkatan kadar kotinin tidak berhubungan dengan efek merugikan yang terdeteksi pada biometri janin maupun aliran arteri umbilikalis. Temuan yang tidak signifikan ini menekankan pentingnya penelitian longitudinal untuk menilai dampak kumulatif paparan asap rokok pasif, terutama pada trimester ketiga dan luaran kelahiran akhir.Kata kunci: Aliran arteri umbilikalis; biometri janin; kotinin; paparan asap rokok pasif
Co-Authors AM, Nasrudin Baharuddin, NurIedil Budipramana, Edwin David Lotisna Diana, Margaret Madya, Fatmawati Maisuri T Chalid, Maisuri T Nusratuddin Abdullah Rahmawati, Rahmawati Riu, Deviana Soraya St Maisuri T Chalid St. Maisuri T. Chalid