Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) YARSI Medical Journal Media Dermato-Venereologica Indonesiana
M. Athuf Thaha
Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin FK UNSRI/RSUP MH Palembang, Jl. Palembang Prabumulih Km. 32 Indralaya Sumatera Selatan
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Autoimmune urticaria in Rumah Sakit Umum Pusat Dr. Moh. Hoesin Palembang Thaha, M. Athuf
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 03 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.239 KB)

Abstract

Background: About 30% patients with chronic idiopathic urticaria (CIU)have circulating histamine-releasing autoantibodies against the a-subunit of high affinity IgEreceptor (FceRla),or IgE.This subgroup of patients has a disorder commonly referred as autoimmune urticaria. Objectives: This study was conducted to reveal the autoimmune urticariacases in Indonesian patients Methods: The autologous serum skin test (ASST)and histamine release assay (HRA)were conducted on 79 patients with CIU (53 females and 26 males). Patients with predominant physical urticaria and urticarial vasculitis were excluded from the study. Results: Seventeen patients had both positive autologous serum skin test and histamine release assay confirmative of autoimmune urticaria. Conclusion:CombinedpositiveASSTand HRAwere seen in 21.5% of CIUpatients, indicatingautoimmune urticaria. Key words: chronic idiopathic urticaria - anti-FceRla histamine-releasing autoantibodies -autoimmune urticaria - autologous serum skin test, histamine release assay.
UJI KULIT SERUM OTOLOG MODIFIKASI PADA PASIEN URTIKARIA OTOIMUN DI RSUP PALEMBANG Thaha, M. Athuf
Jurnal Kedokteran YARSI Vol 16, No 2 (2008): MEI - AGUSTUS 2008
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.93 KB) | DOI: 10.33476/jky.v16i2.240

Abstract

There is an urgent need to find reliable and relevant diagnostic tools for patients with autoimmune urticaria especially in a developing country such as Indonesia. The basophil histamine release assay (HRA) is currently the ?gold standard? for detecting functional autoantibodies in serum of patients with chronic urticaria. However, this bioassay is difficult to standardize because it requires fresh basophils from healthy donors, is not widely commercially available, and is time consuming. The detection of patients with autoantibodies using in vivo autologous serum skin test (ASST) also poses challenges. Firstly, the ASST is at best around 80% sensitive and specific using in vitro HRA as the ?gold standard?, and secondly, there is some divergence results obtained by different methods used to detect patients with autoantibodies, due to inconsistency in methods, results and interpretation of the ASST in the literatures. The purpose of this study was to find and develop a new method of ASST. This new method should be practical and with higher reliability (sensitivity and specificity) as a diagnostic tool for autoimmune urticaria. The method used in this study was to perform a preliminary study followed by advanced study through cross sectional designs. The results of this study showed that the new ASST, has a higher reliability than the former ASST methods reported in literatures. In addition, we also found that disease severity with cut-off value of 12, could be used as an adjunct to detect patients with positive functional autoantibodies. Finally, we also report with pride that we have now the ability to perform HRA which was never done before.
Diagnosis dan Tatalaksana Pioderma Gangrenosum Terkini Diba, Sarah; Yonathan, Erico Lemuel; Thaha, M. Athuf; Nopriyati, Nopriyati; Kartowigno, Soenarto; Devi, Mutia
Media Dermato-Venereologica Indonesiana Vol 52 No 3 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i3.525

Abstract

Pioderma gangrenosum (PG) adalah dermatosis neutrofilik, secara klinis ditandai dengan ulkus kulit nyeri dan berkembang cepat dengan tepi tidak rata, tidak teratur, berwarna ungu kemerahan. Diagnosis PG sulit ditegakkan karena menyerupai penyakit lain, belum ada pemeriksaan baku emas untuk penegakan diagnosis definitif, kriteria diagnosis PG banyak dan bervariasi, sehingga diagnosis perlu ditegakkan sedini mungkin untuk memungkinkan penatalaksanaan yang tepat dan mencegah progresivitas penyakit. Diagnosis PG dibuat dengan menyingkirkan diagnosis lain. PARACELCUS merupakan kriteria diagnostik PG yang dianggap terbaik dan sederhana. Tata laksana PG dipilih berdasarkan tingkat keparahan dan perkembangan penyakit. Tata laksana umum terdiri dari rawat inap, eksklusi penyebab ulkus lain, mengontrol penyakit penyerta, tata laksana komorbiditas, menghindari trauma, tata laksana nyeri, perawatan luka adekuat, pengendalian infeksi penyerta, terapi kompresi untuk mengurangi edema, menjaga kecukupan nutrisi, menghentikan rokok, dan mengontrol glukosa darah. Tata laksana khusus terdiri dari terapi topikal, sistemik, terapi target, dan intervensi. Tata laksana PG masih terus dikembangkan melalui berbagai uji klinis. Pioderma gangrenosum memiliki angka mortalitas dan morbiditas signifikan dengan tingkat rekurensi tinggi sehingga diperlukan diagnosis tepat dan tata laksana segera. 
Co-Authors Diba, Sarah Kartowigno, Soenarto Mutia Devi, Mutia Nopriyati, Nopriyati Yonathan, Erico Lemuel