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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) YARSI Medical Journal Media Dermato-Venereologica Indonesiana
M. Athuf Thaha
Bagian/SMF Ilmu Kesehatan Kulit dan Kelamin FK UNSRI/RSUP MH Palembang, Jl. Palembang Prabumulih Km. 32 Indralaya Sumatera Selatan
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : YARSI Medical Journal

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UJI KULIT SERUM OTOLOG MODIFIKASI PADA PASIEN URTIKARIA OTOIMUN DI RSUP PALEMBANG Thaha, M. Athuf
Jurnal Kedokteran YARSI Vol 16, No 2 (2008): MEI - AGUSTUS 2008
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.93 KB) | DOI: 10.33476/jky.v16i2.240

Abstract

There is an urgent need to find reliable and relevant diagnostic tools for patients with autoimmune urticaria especially in a developing country such as Indonesia. The basophil histamine release assay (HRA) is currently the ?gold standard? for detecting functional autoantibodies in serum of patients with chronic urticaria. However, this bioassay is difficult to standardize because it requires fresh basophils from healthy donors, is not widely commercially available, and is time consuming. The detection of patients with autoantibodies using in vivo autologous serum skin test (ASST) also poses challenges. Firstly, the ASST is at best around 80% sensitive and specific using in vitro HRA as the ?gold standard?, and secondly, there is some divergence results obtained by different methods used to detect patients with autoantibodies, due to inconsistency in methods, results and interpretation of the ASST in the literatures. The purpose of this study was to find and develop a new method of ASST. This new method should be practical and with higher reliability (sensitivity and specificity) as a diagnostic tool for autoimmune urticaria. The method used in this study was to perform a preliminary study followed by advanced study through cross sectional designs. The results of this study showed that the new ASST, has a higher reliability than the former ASST methods reported in literatures. In addition, we also found that disease severity with cut-off value of 12, could be used as an adjunct to detect patients with positive functional autoantibodies. Finally, we also report with pride that we have now the ability to perform HRA which was never done before.
Co-Authors Diba, Sarah Kartowigno, Soenarto Mutia Devi, Mutia Nopriyati, Nopriyati Yonathan, Erico Lemuel