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All Journal Nexus Kedokteran Klinik Plexus Medical Journal
Fadhilah Tia Nur
RSUD Dr. Moewardi/ Faculty of Medicine Sebelas Maret University
Health Professions Medicine & Pharmacology Public Health

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Perbedaan Pemberian Asam Valproat dan Fenobarbital terhadap Kadar Kalsium Darah Pasien Epilepsi Anak di RSUD Dr. Moewardi Kusumaningtyas, Friska; Tia Nur, Fadhilah; Ratna Budiani, Dyah
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background : Antiepileptic drugs have different mechanisms. Meanwhile valproate acid and phenobarbital have similar mechanism, inactivation of voltage gated Ca2+ channels, Na+ channels, and increased activity of GABAergic inhibitory. However, the mechanism of phenobarbital also induces cytochrome P450 (CYP450) enzymes that affect the metabolism of vitamin D. The aim of this study was to examine the differences between valproic acid and phenobarbital on blood calcium levels of pediatric epilepsy. Methods : The cross sectional study was conducted by 24 pediatric epilepsy in the pediatric neurology clinic of RSUD Dr. Moewardi who met the inclusion criteria. Calcium ion levels in blood serum obtained from the medical records of pediatric patients who had been done routine laboratory tests about the side effects of antiepileptic drugs. Data normality was tested by Shapiro-Wilk. The differences of giving valproic acid and phenobarbital on calcium ion level of blood serum were analyzed by the Mann-Whitney test. The correlation between long term drug use and calcium ion levels in blood serum were analyzed by Spearman test. Results : The analysis results show that there is no difference between calcium ion levels in  blood serum of valproic acid and phenobarbital of pediatric epilepsy in RSUD Dr. Moewardi with p = 0.881 (p > 0.05). Correlation analyze show that there is no correlation between duration of drug intake and calcium ion levels in blood serum levels with p = 0.191 (p > 0.05), 35.7% of subjects had a negative correlation for valproic acid and p = 0.548 (p > 0.05), 23.2% of subjects had a negative correlation for phenobarbital. Conclusion : There is no significant difference between calcium ion levels in blood serum of valproic acid and phenobarbital in pediatric epilepsy in RSUD Dr. Moewardi. As well as, there is a weak correlation between duration of drug intake and calcium ion in blood serum. Keywords : epilepsy, antiepileptic drug, valproic acid, phenobarbital, calcium ion 
Hubungan Anemia pada Trimester Ketiga dengan Prematuritas Bayi Baru Lahir di RSUD Dr. Moewardi Surakarta Permata Sari, Dewi; Martuti, Sri; Tia Nur, Fadhilah
Plexus Medical Journal Vol. 2 No. 6 (2023): Desember
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i6.1028

Abstract

Pendahuluan: Prematuritas merupakan sumber utama dari segala komorbid, komplikasi, hingga kematian bayi. Kondisi anemia pada ibu hamil diduga memiliki pengaruh terhadap perkembangan janin, salah satunya bisa mengakibatkan kelahiran bayi prematur <37 minggu. Penelitian ini bertujuan untuk mengetahui hubungan anemia pada trimester ketiga dengan prematuritas bayi baru lahir. Metode: Penelitian observasional analitik dengan pendekatan case control, dilakukan secara retrospektif melalui data rekam medis ibu dan bayi baru lahir di RSUD Dr. Moewardi Surakarta pada bulan Januari-Desember 2022. Sampel penelitian terdiri dari 76 sampel yang terbagi menjadi dua kelompok, yaitu 38 bayi kurang bulan/prematur (preterm) dan 38 bayi cukup bulan (term). Data dianalisis menggunakan uji Chi-square dan uji regresi logistik. Hasil: Terdapat hubungan yang signifikan antara anemia di trimester ketiga (p=0,006; OR 3,850) dan komplikasi kehamilan (p=0,039; OR 3,331) dengan prematuritas bayi baru lahir. Sementara itu, usia ibu (p=0,289; OR 0,489), paritas (p=0,816; OR 1,241), dan status gizi sebelum hamil (p=1,000; OR 1,000) tidak memiliki hubungan yang bermakna terhadap kelahiran bayi prematur. Kesimpulan: Anemia pada trimester ketiga berhubungan signifikan dengan prematuritas bayi baru lahir. Kadar hemoglobin ibu yang rendah dapat meningkatkan kelahiran prematur sebesar 3,85 kali lebih tinggi. Komplikasi kehamilan merupakan prediktor prematuritas bayi selain anemia di trimester tiga.
Co-Authors Dyah Ratna Budiani Friska Kusumaningtyas Permata Sari, Dewi Sri Martuti