Yuni Ernawati
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PENGARUH METODE PENAMBAHAN PVP SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIS TABLET ASAM MEFENAMAT Iskandar Soedirman; Agus Siswanto; Yuni Ernawati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 06 No. 02 Agustus 2009
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v6i2.419

Abstract

ABSTRAK Penelitian ini dilakukan untuk mengetahui pengaruh metode penambahan polivinil pirolidon (PVP) sebagai bahan pengikat terhadap sifat fisis asam mefenamat. Tablet dibuat dengan cara granulasi basah berdasarkan pada cara penambahan dan konsentrasi.F1, F2, F3 berisi 5%, 10%, 15% PVP yang ditambahkan dalam bentuk kering. F4, F5, F6 berisi 5%, 10%, 15% PVP yang ditambahkan dalam bentuk larutan. Tablet yang dihasilkan diuji sifat fisisnya meliputi sifat alir granul, kekerasan tablet, kerapuhan dan waktu hancur. Hasil uji statistika anava dua arah dan uji Duncan menunjukkan terdapat perbedaan yang nyata antara metode penambahan PVP sebagai bahan pengikat terhadap fisis tablet asam mefenamat. PVP lebih efektif sebagai bahan pengikat dalam bentuk larutan daripada kering. Kata kunci: PVP, Bahan pengikat, Tablet, Asam mefenamat ABSTRACT The aim of this research was to study affect addition method of polyvinyl pyrollidon (PVP) as binder on the physical characteristic mefenamic acid tablets. Tablets were made by wet granulation in six formulation based on different addition method and concentration. F1, F2, F3 contain 5%, 10%, 15% PVP in dry form. F4,F5, F6 contain 5%, 10%, 15% which were added in solution. The produced tablets were tested for physical characteristic such as fluidity of granule, uniformity of weight, tablet hardness, friability and disintegration time. The result of annova and Duncan test showed that addition method of PVP as binder difference significancy on physical characteristic of mefenamic acid tablets. PVP more effective as binder in solution rather than in dry form. Keywords: PVP, Binder, Tablets, Mefenamic acids.
Non Adherence to Fluid Restriction among Patients who Undergoing Hemodialysis and Influencing Factors: Study at RSI Sakinah Mojokerto Muhammad Zulfikar Asumta; Herin Mawarti; Siti Urifah; Yuni Ernawati; Mukhoirotin
Journal Of Nursing Practice Vol. 7 No. 2 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jnp.v7i2.502

Abstract

Background: Nonadherence to Fluid Restriction is main problem among chronic renal failure patients who undergoing hemodialysis, it causingan undesirable effect on health and risk of death. Several factors such as sociodemographic, knowledge, susceptibility of illness, perceived treat, perceived controlare some factors influencing Nonadherence behavior. Purpose: The aim of this study was to analyze the factors influencing Non-adherence to Fluid Restriction who undergoing hemodialysis at RSI Sakinah Mojokerto. Methods: A descriptive analytic with crossectional techniques was conducted among 73 patients undergoing hemodialysis at RSI Sakinah Mojokerto by using purposive sampling technique. Data were collected through checklist and questionnaires. Descriptive statistic was used for data analysis and logistic regression test was used analysis the predictor of factors relating with Non-adherence to Fluid Restriction who undergoing hemodialysis. Results: The results of this study showed 37% patients were Non-adherence to Fluid Restriction and 63% patients were adherence. There were three risk factors for non-adherencee, namely (Health Belief Model) HBM, history of disease and length of time undergoing hemodialysis. HBM 0.132 times higher (95% CI: 0.132, 0.035), history of disease 0.072 times higher (95% CI: 0.072, 0.012), and length of time undergoing hemodialysis 0.071 times higher (95% CI: 0.071, 0.016). Conclusion: HBM, history of disease and length of time undergoing hemodialysis were risk factors for Non-adherence to Fluid Restriction. The nurse should consider the patient's adherence with fluid restrictions in providing nursing care.