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All Journal Asean Journal of Science and Engineering (AJSE) Media Pendidikan Gizi dan Kuliner
Gabriela Chelvina Santiuly Girsang
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Engineering Materials Science & Nanotechnology Social Sciences Other

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Techno-Economic Evaluation of Hyaluronic Acid Production Through Extraction Method using Yellowfin Tuna Eyeball Sheren Hana Elia; Brigitta Stacia Maharani; Intan Yustia; Gabriela Chelvina Santiuly Girsang; Asep Bayu Dani Nandiyanto; Tedi Kurniawan
ASEAN Journal of Science and Engineering Vol 3, No 1 (2023): AJSE: March 2023
Publisher : Universitas Pendidikan Indonesia (UPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ajse.v3i1.38281

Abstract

The purpose of this study is to determine the feasibility of a hyaluronic acid fabrication project by extraction and isolation of the fish eyeball, and we evaluated the results from an engineering and economic perspective. Engineering analysis was analyzed based on tools and raw materials that are available on e-commerce. The economic analysis was done using several economic parameters, such as gross profit margin, the length of time required for an investment to return the total initial expenditure, the condition of a production project in the form of a production function in years, project benefits, and so on. The production of Hyaluronic Acid nanoparticles has good prospects. Technical analysis of producing 50.4 g/L of Hyaluronic Acid nanoparticles per day shows the total cost of the equipment purchased to be 20,726 USD. The investment will be profitable after more than four years and compete with the capital market standard. To ensure the feasibility of a manufacturing project, the project is estimated from ideal conditions to the worst conditions in production activities, including raw materials, utilities, sales, labor, and external conditions. The project is prospective and profitable in the small-scale industry, confirmed by positive values in all economic parameters).
Techno-Economic Evaluation of Hyaluronic Acid Drugs Production Through Repeated Batch Fermentation Method using Streptococcus zooepidemicus Intan Yustia; Brigitta Stacia Maharani; Gabriela Chelvina Santiuly Girsang; Asep Bayu Dani Nandiyanto; Tedi Kurniawan
Media Pendidikan Gizi dan Kuliner Vol 10, No 2 (2021)
Publisher : Universitas Pendidikan Indonesia (UPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1049.719 KB) | DOI: 10.17509/boga.v10i2.40776

Abstract

Hyaluronic acid (C14H21NO11)n is one of the drugs components, a natural polysaccharide compound that makes up connective tissue and is soluble in water. HA can be applied in cosmetic, biomedical, and food industries. The purpose of this study was to determine the feasibility of a hyaluronic acid manufacturing project through repeated batch fermentation using Streptococcus zooepidemicus and then evaluating from an engineering and economic perspective. Engineering analysis was analyzed based on the available tools and raw materials in online web. The economic analysis was done using several economic parameters, such as the length of time required for an investment to return the total initial expenditure (PBP), the condition of a production project in the form of a production function in years (CNPV), project benefits and so on. The results showed that the production of Hyaluronic Acid nanoparticles was very prospective. Technical analysis to produce 86.4 g/liter of HA nanoparticles per day shows the total cost of the equipment purchased to be 7,264.51 USD. PBP analysis shows that investment will be profitable after more than three years. This project can compete with PBP capital market standards because of the short investment returns. To ensure the feasibility of a project, the project is estimated from ideal conditions to the worst case in production, including labor, sales, raw materials, utilities, and external conditions. The analysis concluded that the present project for the production of Hyaluronic acid nanoparticles is prospective in small scale industry and profitable (by positive values in all economic parameters).
Co-Authors Asep Bayu Dani Nandiyanto Brigitta Stacia Maharani Intan Yustia Sheren Hana Elia Tedi Kurniawan Tedi Kurniawan