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All Journal Narra J
Zareena Fathah
King’s College London, London, United Kingdom
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Diagnostic performance of GeneXpert MTB/RIF assay compared to conventional Mycobacterium tuberculosis culture for diagnosis of pulmonary and extrapulmonary tuberculosis, Nepal Raina Chaudhary; Sabita Bhatta; Alina Singh; Manoj Pradhan; Brijendra Shrivastava; Yengkokpam I. Singh; Ranjit Sah; Zareena Fathah; Rachana Mehta; Ali A. Rabaan; Alfonso J. Rodriguez-Morales; Kuldeep Dhama
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.33

Abstract

Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis. It is a global health problem and major cause of death in resource-limited countries like Nepal. Timely diagnosis with sensitive testing methods could assist in early management of the disease. This study was conducted to compare the diagnostic performance of GeneXpert MTB/RIF and conventional acid-fast staining with M. tuberculosis culture. The study was carried out in the Department of Microbiology, Shree Birendra Army Hospital, Nepal. Samples (n=500) were tested with a GeneXpert MTB/RIF assay and acid-fast bacilli (AFB) smear microscopy. All samples were sent for M. tuberculosis conventional culture by the German-Nepal Tuberculosis Project, Kathmandu, Nepal (GENETUP). Out of a total 500 pulmonary and extrapulmonary samples tested, 97 samples were positive for M. tuberculosis by GeneXpert MTB/RIF assay. Out of the positive samples, only 95 samples were found positive by the culture method. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of AFB microscopy was 45.3%, 99.5%, 99.5% and 88.5%, respectively. The sensitivity, specificity, PPV and NPV of GeneXpert MTB/RIF was found to be 100%, 99.5%, 97.5% and 100%, respectively compared to the gold standard culture method. The GeneXpert MTB/RIF test was comparable with culture diagnosis of both pulmonary and extrapulmonary tuberculosis cases.
SARS-CoV-2 and Orientia tsutsugamushi co-infection in a young teen, Nepal: Significant burden in limited-resource countries in Asia? Anup Bastola; Ranjit Sah; Sagar K. Rajbhandari; Runa Jha; Zareena Fathah; Bimal S. Chalise; Bikesh Shrestha; Rajesh K. Shah; Pujan Balla; Richa Nepal; Bipin Adhikari; Ali A. Rabaan; Kuldeep Dhama; Alfonso J. Rodriguez-Morales
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.34

Abstract

Scrub typhus is caused by Orientia tsutsugamushi, transmitted through bites of infected chiggers (larval mites). During the coronavirus disease 2019 (COVID-19) pandemic, reports of co-infections with endemic pathogens are increasing around the world. Disease with similar clinical presentation may mask other disease diagnosis and increase the morbidity and mortality of the patients. We report co-infection between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and O. tsutsugamushi in a patient in Nepal presenting with fever, headache, retro-orbital pain, generalized body ache, and knee joints pain with a history of dry cough and dyspnea at night. Since scrub typhus is prevalent and considerate as one of the public health consents in Asian countries and the possible overlapping clinical manifestation with other infections including COVID-19, a further investigation required to determine the burden of SARS-CoV-2 and O. tsutsugamushi co-infection in scrub typhus-endemic countries in Asia.
Co-Authors Alfonso J. Rodriguez-Morales Alfonso J. Rodriguez-Morales Ali A. Rabaan Ali A. Rabaan Alina Singh Anup Bastola Bikesh Shrestha Bimal S. Chalise Bipin Adhikari Brijendra Shrivastava Kuldeep Dhama Kuldeep Dhama Manoj Pradhan Pujan Balla Rachana Mehta Raina Chaudhary Rajesh K. Shah Ranjit Sah Ranjit Sah Richa Nepal Runa Jha Sabita Bhatta Sagar K. Rajbhandari Yengkokpam I. Singh