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All Journal Pharmed: Journal of Pharmaceutical Science and Medical Research An-Nadaa: Jurnal Kesehatan Masyarakat Saintara : Jurnal Ilmiah Ilmu-Ilmu Maritim Pharmacy Peradaban Journal (Pharm. PJ): Jurnal Farmasi Universitas Peradaban Parapemikir Jurnal Ilmiah Farmasi Jurnal Kesehatan Bakti Tunas Husada
Luthfi Hidayat Maulana
Fakultas Sains Dan Teknologi Universitas Peradaban
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary

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PENGARUH DUKUNGAN KELUARGA, PENGETAHUAN DAN SIKAP TERHADAP KEPATUHAN MINUM OBAT ANTIBIOTIK PASIEN PNEUMONIA DI RSUM AMINAH BUMIAYU TAHUN 2025 luthfi hidayat maulana
An-Nadaa : Jurnal Kesehatan Masyarakat (e-Journal) Vol 13 No 1 (2026): AN-NADAA JURNAL KESEHATAN MASYARAKAT (JUNI)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v13i1.20448

Abstract

Penggunaan antibiotik pada pasien lanjut usia dengan Community Acquired Pneumonia (CAP) dikaitkan dengan penurunan klinis pasien, dan terapi antibiotikal harus dilanjutkan sampai pasien mencapai keadaan klinis stabil yang tidak boleh memakan waktu lebih dari 5 hari. Kementrian Kesehatan menyebutkan bahwa kematian akibat Pneumonia  pada tahun 2024 meningkat tiga kali lipat menjadi 188 orang. Penelitian bertujuan untuk mengetahui pengaruh dukungan keluarga ,pengetahuan dan sikap terhadap kepatuhan minum obat antibiotik pada pasien pneumonia di RSUM Aminah Bumiayu tahun 2025. Penelitian ini merupakan penelitian observasional dengan menggunakan rancangan penelitian prospektif yang bersifat deskriptif analitik. Jenis penelitian merupakan survei analitik dengan pendekatan cross-sectional. Besar sampel penelitian sebanyak 120 responden dan teknik pengambilan sampel menggunakan accidental sampling. Uji statistik yang digunakan adalah Uji analisis linear berganda. Berdasarkan hasil analisis menunjukkan bahwa terdapat pengaruh antara dukungan keluarga (p-value=0,000), pengetahuan (p-value=0,003) dan sikap (p-value=0,000) dengan kepatuhan minum obat antibiotik pasien pneumonia di RSUM Aminah Bumiayu tahun 2025. Kata Kunci: Pneumonia, dukungan keluarga, pengetahuan, sikap, kepatuhan minum obat 
POTENSI SENYAWA ANTI INFLAMASI DARI DAUN SIRSAK (Annona muricata L.) PADA ENZIM COX-2 SECARA IN SILICO Syaiful Prayogi; Teguh Hary Kartono; Luthfi Hidayat Maulana; Miftahul Saldi; Yulita Amelia
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 1 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i1.1548

Abstract

Inflammation is still a major cause of death in the world, especially in tropical regions (including Indonesia). The use of non-steroidal anti-inflammatory drugs (NSAIDs) has many side effects and is even toxic. Efforts to find drugs with low toxic effects require long stages and high costs. This effort can be accelerated with a computational approach in the early stages of drug development through the CADD technique by minimizing the risk of failure in later stages. The protein that plays a role in delaying inflammation is the cyclooxygenase (COX) enzyme. Inhibition of COX-2 has much lower side effects than inhibition of COX-1. COX-2 is induced by inflammatory stimuli expressed in synovial cells, leukocytes, fibroblasts, and macrophages, therefore becoming one of the target proteins in inflammation. Natural compounds of the phenolic, flavonoid, and alkaloid groups have been reported to have potential as anti-inflammatories. Soursop leaves are known to be rich in flavonoids. The empirical efficacy of soursop leaves (Annona muricata L.) has been known by the Indonesian people in the treatment of rheumatism or rheumatoid arthritis, anti-inflammatory, antipyretic, and analgesic. This study was conducted in silico with a molecular docking approach using iGemDock v2.1 software. The binding between ligand-target (COX enzyme) was evaluated using Discovery Studio Visualizer. The results showed that all test compounds inhibited COX-2, the isohamnetin 3 robinobioside compound has the potential to be a selective inhibitor of COX-2 when compared to other test compounds and with a reference drug (ibuprofen).
Co-Authors Andi Hendrawan Aulia Rahman Aziez Ismunandar Aziez Ismunandar Dian Trimajaya Ika Yuliani Liana Fijriati Miftahul Saldi Pudjono Pudjono Ratu Fiqi Hanun Resa Frafela Rosmi Sabila Zela Safitri Syaiful Prayogi Syaiful Prayogi Teguh Hary Kartono Teguh Hary Kartono Tunjung Winarno Umatus Sodiqoh Yulita Amelia