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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia
Mirnasari Amirsyah
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Physics Social Sciences Other

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Healing Potential of Chromolaena odorata Extract: Modulation of Neutrophil, Macrophage, and Lymphocyte Response in Infected Wounds of Mus musculus Melissa Abigail Yanis; Mirnasari Amirsyah; Anastasia Dessy Harsono
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9423

Abstract

Chromolaena odorata has been reported to possess antimicrobial, antibacterial, and anti-inflammatory properties that aid in wound healing. Previous studies demonstrated the significant effects of a 7.5% concentration of C. odorata extract on non-infected wounds. This study aims to investigate its impact on infected wound healing. An experimental study was conducted on 36 mice, divided into two groups. Partial-thickness wounds were created on the dorsal side of each mouse and contaminated with S. aureus (106 CFU/ml). Group 1 was treated with normal saline, while Group 2 was treated with C. odorata aqueous extract at 7.5%. Histopathological analysis was performed on days 3 and 5 to count neutrophils, macrophages, and lymphocytes. Results showed a significantly lower neutrophil, macrophage, and lymphocyte count in Group 2 compared to Group 1 (p < 0.05). On day 3 and 5, Group 2 had lower neutrophil counts (5.6 ± 1.8, 5.8 ± 0.6) compared to Group 1 (9.2 ± 5.2, 15.1 ± 3.9). Macrophage counts were also lower in Group 2 (6.9 ± 1.7, 1.9 ± 0.7) compared to Group 1 (3.7 ± 1.4, 4.3 ± 0.9). Lymphocyte counts followed a similar trend, with Group 2 having fewer lymphocytes on both days (p < 0.05). In conclusion, C. odorata aqueous extract at a 7.5% concentration demonstrates potential as a wound healing agent by reducing inflammatory cells in infected wounds.
Surgical Management of a Rare Alar Cleft: A Case Report Damar Dita Kirana; Indri Lakhsmi Putri; Mirnasari Amirsyah
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i4.64417

Abstract

Alar cleft is a rare congenital nasal deformity affecting the nasal ala. It can be associated with craniofacial syndromes or isolated anomalies. Isolated congenital alar clefts are exceptionally uncommon, and only limited cases have been reported in the literature, making this condition a significant reconstructive challenge in pediatric patients. There are no criteria guiding the correction of congenital alar anomalies; therefore, surgical corrections might be challenging. A 3-month-old infant presented with an uncommon congenital alar cleft, leading to aesthetic concerns. We performed a surgical procedure by dividing the anterior and posterior flaps, trimming them, and connecting them with the nasal alar skin. This surgical technique is clinically important because it preserves native tissue, provides good vascularity and tissue alignment, minimizes visible scarring, and avoids the need for more complex grafting procedures. Postoperative follow-up showed significant improvement in nasal contour and symmetry; no complications such as wound dehiscence were reported. Various surgical techniques have been described for alar cleft repair. The choice of technique depends on the size and location of the defect, and surgeon experience. The chosen technique ensures good tissue alignment with minimal scarring. There are no specific techniques for repairing alar clefts. The goal of surgery is to achieve normal-like results. Early surgical intervention yields better outcomes, especially in psychological issues. This case also highlights the broader importance of individualized planning in pediatric reconstructive surgery, particularly in preserving facial growth, achieving long-term aesthetic outcomes, and improving quality of life in children with rare craniofacial anomalies.
Co-Authors Anastasia Dessy Harsono Damar Dita Kirana Indri Lakhsmi Putri Melissa Abigail Yanis