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All Journal SRIWIJAYA JOURNAL OF MEDICINE Conferences of Medical Sciences Dies Natalis
Wresnindyatsih Wresnindyatsih
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Penanganan Spesimen Jaringan Dan Sitologi Pada Tahap Preanalitik Wresnindyatsih
Conferences of Medical Sciences Dies Natalis Vol. 1 No. 1 (2019): Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sr
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Anatomical Pathology Examination is an examination of specimens from the results of operations and or other medical proceeding on patients. This examination is carried out to establish a diagnosis of a disease. The stages of specimen handling are interrelated with one another. This will affect the accuracy of the pathology diagnosis. In the molecular era specimen handling is becoming increasingly important and must be done carefully according to established standards. The purpose of this review is to discuss the standard procedures for the preanalytic stage of specimen handling before examining in the Anatomy Pathology Laboratory.
THE IMPORTANCE OF ADEQUATE PRE-ANALYTICAL MANAGEMENT FOR HISTOLOGICAL AND MOLECULAR EXAMINATION FOR DIAGNOSTIC PURPOSES Krisna Murti; Nora Ramkita; Neti Neti; Aida Farida; Wresnindyatsih Wresnindyatsih; Aspitriani Aspitriani; Susilawati Susilawati
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Almost all Anatomic Pathology laboratories have experienced that tissue patient who comes to these laboratories without adequate fixation and causes complicated patient diagnosis. In addition, adequate fixation also makes advanced procedures such as immunohistochemical staining or DNA and RNA extraction difficult because protein, DNA, and RNA become damaged due to inadequate fixation. The fixation procedure should be the responsibility of the clinicians, specifically surgeons and team. If this procedure is not carried out appropriately resulting in damage to the tissue due to the natural process, namely autolysis, which the fixation procedure can prevent. This autolysis will damage the tissue. The laboratory process results are not optimal, complicating the evaluation of patient tissues, resulting in difficulty and delay of diagnosis. If further examination is needed, such as immunohistochemistry and other molecular examinations related to the extraction of DNA or RNA, the examination results will also be not optimal. Moreover, patient therapy becomes delayed or difficult. For this reason, we conducted extension activities for health workers, some of whom may be involved in a team of surgeons. Knowledge of pre-analytic procedures can improve the quality of pre-analytical handling, which will improve the quality of tissue andcytology specimens; hence, a precise and optimal diagnosis can be obtained. This will help the clinicians in determining the patient's therapy. Therefore, morbidity and mortality rates of patients can be reduced.
Hubungan Antara Ekspresi Reseptor Estrogen, Progesteron dan Ki67 dengan Karakteristik Klinikopatologi pada Karsinoma Payudara Subtipe Luminal A Adrina Esther Liaw; Wresnindyatsih Wresnindyatsih; Sri Nita; Krisna Murti; Budi Santoso
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.139

Abstract

Karsinoma payudara subtipe luminal A adalah ER positif dan atau PR positif, Her-2 negatif, dan Ki67 <20% dan merupakan subtipe yang sering dijumpai dengan prognosis yang lebih baik dibandingkan dengan subtipe lain. Penelitian ini dilakukan untuk mengetahui hubungan karakteristik klinikopatologi dengan status ER dan PR pada karsinoma payudara subtipe luminal A di Laboratorium Patologi Anatomi RSUP Dr. Mohammad Hoesin Palembang. Jenis penelitian ini berupa observational analitik dengan desain penelitian cross-sectional teknik purposive sampling. Populasi dari penelitian ini adalah semua pasien yang terdiagnosis karsinoma payudara di RSUP Dr. Mohammad Hoesin Palembang dengan sampel penelitian berupa wanita yang terdiagnosis karsinoma payudara subtipe luminal A. Berdasarkan karakteristik klinikopatologi, karsinoma payudara subtype luminal A banyak ditemukan pada kelompok usia 41-50 tahun (34.7%), berada dalam stadium III (75.3%) dan jenis histologi yang banyak ditemukan berupa karsinoma invasif NST (77.3%), sering ditemukan pasien dengan derajat histopatologi grade III (53.3%) dan banyak pasien ditemukan mempunyai metastasis limfonodus (41.3%). Pasien karsinoma payudara subtype luminal A lebih dominan memiliki ekspresi ER dan PR positif (92.0% dan 94.7%). Penelitian ini tidak menemukan hubungan yang signifikan antara karakteristik klinikopatologi dengan status ER dan PR pada karsinoma payudara subtipe luminal A. Namun pada ekspresi Ki67, dijumpai terdapat hubungan yang signifikan antara Ki67 dengan derajat histopatologi. Kesimpulan dari penelitian ini adalah status ER dan PR tidak mempunyai hubungan langsung terhadap karakteristik klinikopatologi pada karsinoma payudara subtipe luminal A.
Co-Authors Adrina Esther Liaw Aida Farida Aspitriani Aspitriani Budi Santoso Krisna Murti Mudinillah, Adam Neti Neti Nora Ramkita Sri Nita