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Babay Asih Suliasih
Faculty Of Pharmacy, Universitas Indonesia, Gedung A Rumpun Ilmu Kesehatan, Kampus UI Depok, Kota Depok, Jawa Barat, 16424, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology

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Phyllantin Extraction Using Imidazolium Ionic Liquids with Chloride and Bromide Anion by Microwaved Assisted Extraction Method Babay Asih Suliasih; Surya Geraldi; Hana Yunita Hidayat; Abdul Mun'im; Eko Aditya Rifai
Chemistry and Materials Vol. 2 No. 1 (2023)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (857.031 KB) | DOI: 10.56425/cma.v2i1.47

Abstract

Phyllanthin is known to have therapeutic properties such as immunomodulator, nephroprotective, and anticancer. Phyllanthin is a lignan compound that is commonly found in plants of the Phyllanthus genus, one of which is green meniran (Phyllanthus niruri). Solvent Ionic Liquid (IL) is one of the alternative solvents that are widely used for the extraction of compounds from a plant. The purpose of this study were to compare the extraction yield of philanthine compounds from meniran herbs using IL solvent by Microwave Assisted Extraction (MAE) with methanol by maceration method, and to determine the IL solvent that could produce the highest phyllanthin content. Optimization were carried out using the independent variables IL solvent concentration (0.25 M, 0.75 M, and 1.25 M) and sample-solvent mixture (1:10, 1:12, and 1:14). The variable modeling is designed using Response Surface Methodology that produced 9 runs of combination of solvent concentration and sample-solvent mixture ratio. The phyllanthin assay was using High Performance Liquid Chromatography (HPLC) with ethanol-water mixture (66:34) as mobile phase and wavelength at 229 nm for detection. The optimum extraction conditions showed the best results for imidazolium chloride IL at 1st run with a concentration of 0.75 M, the sample-solvent mixture of 1:14 and phyllanthin content of 0.1783 mg/g while imidazolium bromide IL at 7th run with a concentration of 0.75 M and the sample-solvent mixture of 1:12 and phyllanthin content of 0.23 mg/g. However, the methanol maceration method could only extract phyllanthin as much as 0.1319 mg/g. Based on these results, the use of IL-MAE was more effective than the methanol maceration method due to higher phyllantin extract.
Scan rate Dependent Factor for Antioxidant Activity of Gold Nanofilms Synthesized via Cyclic Voltammetry Technique Babay Asih Suliasih; Dwi Giwang Kurniawan; Annisa Auliya; Marissa Angelina
Chemistry and Materials Vol. 2 No. 2 (2023)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56425/cma.v2i2.60

Abstract

Gold nanoparticles (AuNPs) were found to act as antioxidants owing to their inert, high stability, biocompatibility, and non-cytotoxic. The present investigation involved the synthesis of gold nanoparticles through the electrodeposition technique on a substrate comprising Fluorine-doped Tin Oxide (FTO). By manipulating the scan rate parameter, an effective approach can be employed to facilitate precise management of particle morphology and size. The obtained shape of AuNPs were spherical and irregular. In this study, it was observed that gold nanoparticles elicited potent inhibition, particularly at a scan rate of 150 mV/s, with a markedly high inhibition value of 41.27%. The outcome was further supported by an augmented particle distribution density per unit area, which measured as 149,635,036.5/mm².
Review: Potency and Problem in Development of Self-reliance of Traditional Drug Raw Material in Indonesia Suliasih, Babay Asih; Mun'im, Abdul
Chemistry and Materials Vol. 1 No. 1 (2022)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (772.573 KB) | DOI: 10.56425/cma.v1i1.22

Abstract

The use of herbs for health purposes has been practiced for thousands of years, long before the discovery of synthetic chemical drugs. Indonesia is widely recognized for its vast biodiversity, boasting approximately 30,000 plant species, equivalent to 75% of the total plant species worldwide, earning it the title of a mega-centre of global biodiversity. This highlights Indonesia's enormous potential in the traditional medicine industry, with the capability to compete on a global scale. However, several challenges hinder the development of traditional raw materials and the production of traditional medicines. These include herbal raw materials that fail to meet quality standards, a non-conducive business climate, limited technological advancements in the extraction and production of raw materials, uneven distribution of third-party laboratories across Indonesia which making it difficult for small and medium-sized industries to access product testing facilities, the exclusion of traditional medicines from the National Health Insurance (JKN) program, and a lack of empirical evidence for many plants with potential as traditional medicines. To address these challenges, intensive support and synergy from the government and legislative bodies are essential to enact policies that accelerate the growth of the traditional medicine industry. Additionally, strong collaboration with business actors, academics, and community organizations is crucial to fostering self-sufficiency in traditional medicine raw materials.
The The Effect of Electrodeposition Voltage on the Antioxidant Activity of Gold Nanoparticles Suliasih, Babay Asih; Sakinah, Anis; Marissa Angelina
Chemistry and Materials Vol. 3 No. 1 (2024)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56425/cma.v3i1.72

Abstract

Gold nanoparticles (AuNPs) are well known as free radical scavengers, which may induce cell damage, triggering degenerative diseases and premature aging. This research aims to assess the antioxidant activity of AuNPs synthesized via the electrodeposition method, employing cyclic voltammetry on a Fluorine-doped Tin Oxide (FTO) substrate. By varying the initial voltage, the resulting AuNPs exhibit  variations in both particle size and number. In this study, AuNPs demonstrated promising antioxidant potential, particularly at an initial voltage of -1 V, as evidenced by their ability to respond to DPPH radicals, yielding a percent inhibition of up to 36.80%.
Morphology-Dependent Antioxidant Activity of Gold Nanoparticles Prepared Using Different Electrolyte Concentrations Abd Aziz, Azri Farhanah; Suliasih, Babay Asih
Chemistry and Materials Vol. 4 No. 1 (2025)
Publisher : Pusat Inovasi Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56425/cma.v4i1.93

Abstract

Antioxidants play a crucial role in protecting the body from oxidative stress by neutralizing free radicals. The synthesis of antioxidant-active materials, such as gold nanoparticles (AuNPs), offers significant advantages due to their unique physicochemical properties. In this study, AuNPs were successfully synthesized using the electrodeposition method on indium-tin oxide substrates, with varying Na₂SO₄ electrolyte concentrations. Scanning electron microscopy analysis confirmed that the synthesized AuNPs exhibited a round to slightly irregular morphology, with an average particle size ranging from 48 to 65 nm. X-ray diffractometer characterization revealed that the nanoparticles possessed a face-centered cubic crystal structure, confirming their high purity. Antioxidant activity was evaluated using the DPPH assay, where AuNPs synthesized with 0.5 M Na₂SO₄ exhibited the highest DPPH inhibition of 72.39%. This enhanced antioxidant performance is attributed to the smaller particle size, which increases the available surface area for free radical neutralization. These findings highlight the potential of electrodeposited AuNPs as effective antioxidants and provide valuable insights into optimizing nanoparticle synthesis for biomedical and nanotechnological applications.
Co-Authors Abd Aziz, Azri Farhanah Abdul Mun'im Anis Sakinah, Anis Annisa Auliya Dwi Giwang Kurniawan Eko Aditya Rifai Hana Yunita Hidayat Marissa Angelina Marissa Angelina Mun'im, Abdul Surya Geraldi