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All Journal Pharmaciana: Jurnal Kefarmasian

Agung Giri Samudra

Bengkulu University

Author-ID : 4103035

Medicine & Pharmacology

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Incision wound healing test ethanolic extract gel from Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves in white male rats Fathnur Sanik; Havizur Rahman; Ave Olivia Rahman; Agung Giri Samudra; Cassa de Floris; Muhaimin Muhaimin
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ekor naga (Rhaphidophora pinnata (L.f) Schott) leaves have been researched and tested. So, it was known that the chemical content of secondary metabolites effect wound healing. This study aimed to determine the gel effect of ekor naga leaves extracts as a wound healing medicine. The research method evaluated organoleptic, pH, spreadability, and adhesion of gel preparations which were measured every week for four weeks. The testing of gel effect on the wound healing medicine was being performed. In 5 treatment groups namely positive control: Bioplasenton, Formula 0: negative control, Formula 1: 10% extract concentration, Formula 2: 15% extract concentration, and Formula 3: 20% extract concentration. The result obtained were analyzed by one-way ANOVA and continued by the Duncan test with a level of 95% confidence. The research results showed that formula 3 has the best wound healing effect, followed by formulas 2 and 1. The statistical results have a significant difference (p<0,05), but the results of stability observations of the formula two preparation have a stable. Evaluation value for four weeks of observation with a care effect of 95.3%. So, formula 2 is the best formula for stability and testing wound healing effectiveness.

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Fathnur Sani K; Yuliasati Yuliawati; Havizur Rahman; Agung Giri Samudra
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0th, 7th, 10th, and 14th. Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14th day. Results were analyzed by one-way ANOVA test. The followed by Duncan’s test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.

Co-Authors Ave Olivia Rahman Cassa de Floris Havizur Rahman Muhaimin Muhaimin Sani K, Fathnur Yuliawati Yuliawati

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