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Frenly Wehantouw
Jurusan Farmasi Fak MIPA UKIT Tomohon Hl Kampus Unsrat, Bahu Manado 95115
Chemistry Medicine & Pharmacology

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AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) PADA TIKUS YANG DIINDUKSI SUKROSA Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 4, No 2 (2011)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.4.2.2011.4980

Abstract

Garcinia manggostana L. telah digunakan secara tradisional oleh masyarakat sebagai tanaman obat dandibuktikan secara ilmiah memiliki aktivitas antioksidan yang tinggi. Tujuan penelitian ini adalah menentukanaktivitas antihiperglikemik ekstrak kulit Garcinia manggostana L. terhadap tikus yang diinduksi sukrosa. Profilgula ditentukan pada saat awal dan akhir perlakuan. Hasil pengujian menunjukkan bahwa ekstrak kulitG. manggostana L. menunjukkan aktivitas antihiperglikemik terhadap tikus yang diinduksi sukrosa selama 4jam. Ekstrak kulit G. manggostana L. mengandung alkaloid, flavonoid, tannin, saponin dan triterpenoid.Spektrum ultraviolet menunjukkan karakteristik golongan flavon dalam ekstrak kulit G. manggostana L.Senyawa antioksidan dan fenolik dalam ekstrak berperan sebagai antihiperglikemik. Studi lebih lanjutdiperlukan untuk menguji efektivitas pada manusia. Kata kunci : Garcinia manggostana L., antihiperglikemik, tikus, sukrosa
PHYTOCHEMICAL ANALYSES AND FREE RADICAL SCAVENGING ACTIVITY FROM TUIS (Nicolaia speciosa, HORAN) Kojong, Novel; Monintja, John; Wehantouw, Frenly; Paendong, Edwin
CHEMISTRY PROGRESS Vol 3, No 1 (2010)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.3.1.2010.74

Abstract

Tuis (Nicolaia speciosa, Horan) is a plant which used by people to give taste and odor on food, and it also usedas herbal.The objective of this research was to determine phytochemical content and free radical scavengingactivity from Tuis. Phytochemical content in Tuis was determined by its alkaloid, steroid, flavonoid, phenolic,tannins and saponim content. Free radical scavenging activity from Tuis was determined using 1,1-difenil-2-pikrilhidrazil (DPPH) method.Tuis contain phytochemical such as alkaloids, terpenoid, saponim and tannins,although flavonoid appear only in leaves part. The highest free radical scavenging activity from Tuis was leavesextract, with IC50 1,77. Phenolic content in Tuis was believed act as antioxidant.
POTENSI DAUN ALPUKAT (Persea Americana Mill) SEBAGAI SUMBER ANTIOKSIDAN ALAMI Katja, Dewa Gede; Suryanto, Edi; Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 2, No 1 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.1.2009.65

Abstract

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AKTIVITAS PENANGKAP RADIKAL BEBAS DARI EKSTRAK FENOLIK DAUN SUKUN (Artocarpus altilis F.) Suryanto, Edi; Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 2, No 1 (2009)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.2.1.2009.56

Abstract

The objectives of this study was to determine phytochemicals content and free radical scavengingactivities of bread fruit leaves. Bread fruit leaves were finely ground in a laboratory mill and samples wasextracted with methanol, ethanol and acetone under room temperature, respectively. Analyses ofphytochemicals based on total phenolic, flavonoid and condensed tannins. The radical scavengingactivities of extracts were determined by 1.1-diphenyl-2-picrylhydrazyl (DPPH) and the ferric reducingability plasma assay. The highest total phenolic content was in methanol extract (EM), followed byethanol extract (EE) and acetone extract are 179.89 ± 3.17; 152.55 ± 3.17 and 62.46 ± 1.31 mg/Kgrespectively. EM possessed highest contents of total flavonoid and condensed tannins compared with EEand EA. The addition of methanol extracts of in the reaction mixture showed the highest scavengingactivity in 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical 74.80% followed by EE 71.80% and 38.80%.These result suggested that contains phenolic compounds groups having free radical scavengingactivities.
ANTI-PHOTOOXIDATIVE EFFECT OF PHENOLIC EXTRACT FROM CLOVE PARASITE (Flower) IN SYSTEM MODEL Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 1, No 2 (2008)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.1.2.2008.4958

Abstract

Clove parasite is a herbal plant commonly used in north sulawesi. Its traditionally used to cure many kindof disease, especially cancer. The objectives of this study was to determine antiphotooxidation activities ofclove parasite flower on linoleic acid 0,03 M under illuminate with 4000 lux fluoresence lamp for 5 hours.Analyses of antiphotooxidation activities based on Lee et al. (1997) method and analyses of rancidity oflinoleic acid was determine with AOCS 1990 methods. The addition of clove parasite flower extracts in thereaction mixture showed antiphotooxidation activities on linoleic acid 0,03 M. The mixture with extractshow lower peroxide value compare with control without extract after 5 hours light exposure at roomtemperature. Activities as antiphotooxidation of clove parasite extract may cause by phenolic compoundon this plant Keywords: clove parasite, linoleic acid, antiphotooxdation, peroxide value
TOTAL ANTIOKSIDAN DARI BEBERAPA JENIS SAYURAN TINUTUAN YANG DITANAM DI DAERAH BERBEDA KETINGGIAN Momuat, Lidya; Fatimah, Feti; Wehantouw, Frenly; Mamondol, Oktavianus
CHEMISTRY PROGRESS Vol 4, No 1 (2011)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.4.1.2011.26499

Abstract

ABSTRACTMomuat et al., 2011. Total antioxidant of some Tinutuan vegetables planted in different altitude places.A research was done to to study the effect of altitude on total antioxidant some tinutuan vegetables. Totalantioxidant of some vegetables was evaluated using ferric reducing antioxidant plasma method. The resultsshow that vegetables treat by heating possessed high antioxidant activity. Total antioxidant of gedi, spinach,kangkung and kemangi from Tomohon were 0.02, 1.37, 0.06 and 0.08, respectively. Total antioxidant of gedi,spinach, kangkung and kemangi from Manado were 0.36, 1.84, 0.30 and 0.58, respectively. High totalantioxidant activity of vegetables from Manado caused by Manado land contain more minerals to support plantgrowth and metabolism.Keywords : altitude, vegetables, tinutuan, total antioxidant
PENGARUH LEMON KALAMANSI (Citrus microcarpa) TERHADAP KOMPOSISI KIMIA DAN FITOKIMIA ANTIOKSIDAN DARI TEPUNG PISANG GOROHO (Musa spp.) Suryanto, Edi; Momuat, Lidya; Taroreh, Mercy; Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 4, No 1 (2011)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.4.1.2011.26500

Abstract

ABSTRACTSuryanto et al., 2011. Effect of callamansi citrus (Citrus microcarpa ) on chemical composition and antioxidantphytochemical of Goroho (Musa spp.) banana flour.The objective of this research was to study chemical composition and measured antioxidant activity of gorohobanana flour which immersed with callamansi. The goroho banana was soaked with water, callamansi andsodium methabisulfit for 60 minute. Furthermore, each flour were analyzed its phytochemical such as,proximate analysis, total phenolic content, flavonoid, condensed tannin, carotenoid, ascorbic acid, totalantioxidant using titration and spectrophotometer method. The results showed that callamansi addition of 1%was the best treatment for banana flour. The product had content of moisture, ash, fat, protein, fiber andcarbohydrate were 4.29 ± 0.01; 3.74 ± 0.02; 3.03 ± 2,04; 1.47 ± 0.57; 4.75 ± 0.57 and 85.70 ± 0.59,respectively. The banana flour soaked with callamansi for 60 minute had phenolic, flavonoid, condensed tannintotal content were 55.82 ± 0,01; 6.27 ± 0.08 and 36.50 ± 0.24 mg/kg, respectively. Whereas ascorbic acid andcarotenoid total content of goroho banana flour were 51.92 ± 3.73 and 6.36 ± 1.13mg /kg sample, respectively.Total antioxidant of banana flour extract soaked with callamansi shows high activity compared without soakedand soaked with sodium methabisulfit for 60 minute. The results showed that banana flour immersed withcalamansi extract and sodium metabisulfit possess different proximate composition (p<0.05). Banana immersedwith calamansi extract appears to increase phenolic, flavonoid, condensed tannin, ascorbic acid content as wellas the capacity antioxidant of banana four.Keywords : goroho banana, proximate, flour, callamansi, antioxidant phytochemical
Singlet Oxygen Quenching Activities Of Phenolic Extract From Lemon Grass Leaves (Cymbopogon citratus Stapf) Suryanto, Edi; Katja, Dewa Gede; Wehantouw, Frenly
CHEMISTRY PROGRESS Vol 3, No 1 (2010)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.3.1.2010.67

Abstract

Lemon grass (Cymbopogon citratus Stapf) is a traditional food ingredient characterized by its specific andrefreshing aroma. This objectives of study was determined phytochemical contents and the effect of lemongrass leaves extract in photooxidation linoleic acid and ascorbic acid in system model. Lemon grass leaves wasextracted sequentially with hexane and methanol. The photooxidation reaction system was consisted of linoleicacid 0.03 M in ethanol containing 0.017 mM erythrosine as sensitizer the reaction mixture was exposed under4000 lux fluorescent light up to 5 hours while ascorbic acid 200 μg/mL in phospat buffer solution (pH 7.5)containing 0.0068 mM erythrosine as sensitizer illuminated for 20 minutes. Analyses of phytochemical based ontotal phenolic and flavonoid. Analyses of photooxidation of linoleic acid based on peroxide value anddegradation of ascorbic acid was analyzed using the spectrophotometer at λ 265 nm. The total phenolic andflavonoid content in hexane extract showed the highest phenolic content than methanol extract. Hexane extract1500 ppm exhibited singlet oxygen quenching effect on photooxidation linoleic acid compared with methanolextract, peroxide value 3.57 and 3.72 meq/kg after 5 hours illumination, respectively. Hexane extract 100 ppmalso exhibited singlet oxygen quenching effect on photooxidation ascorbic acid compared with methanol extract,ascorbic acid content 185.44 and 76.67 mg/kg after 5 hours illumination, respectively. It’s concluded thathexane extract of lemon grass leaves contain phenolic component that have singlet oxygen quencher activity.
PENGARUH FOTOOKSIDASI TERHADAP AKTIVITAS ANTIOKSIDAN VIRGIN COCONUT OIL Wehantouw, Frenly; Roreng, Matheda K
CHEMISTRY PROGRESS Vol 14, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.14.2.2021.37288

Abstract

ABSTRAK Virgin Coconut Oil (VCO) merupakan produk olahan kelapa tanpa pemanasan. VCO merupakan produk yang memiliki aktivitas antioksidan. Tujuan penelitian yaitu menguji aktivitas antioksidan Virgin Coconut Oil yang diberikan pencahayaan. Sistem fotooksidasi menggunakan kota cahaya yang dimodifikasi menggunakan lampu fluorescen. Fotooksidasi VCO menggunakan eritrosin sebagai sensitizer. Aktivitas antioksidan diuji menggunakan metode penangkalan radikal bebas DPPH, selanjutnya nilai IC50 ditentukan menggunakan analisis probit. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi VCO maka aktivitas antioksidan akan semakin tinggi, nilai IC50 sebesar 12,02%. Aktivitas antioksidan Virgin Coconut Oil yang dicahaya selama 7 jam mengalami menurunan menjadi 96,13%. Larutan VCO yang mengandung eritrosin mengalami penurunan absorbansi sebesar 0,121 selama proses fotooksidasi. Kesimpulan penelitian ini ialah cahaya menyebabkan reaksi fotooksidasi sehingga menurunkan aktivitas antioksidan VCO.ABSTRACT Virgin Coconut Oil is a coconut processed product without heating. VCO is a product that has antioxidant activity. The research objective was to test the antioxidant activity of Virgin Coconut Oil under lighting. Photooxidation system using a modified light box of fluorescent light, while its antioxidant activity was tested using the DPPH free radical scavenging method, the IC50 value was determined using probit analysis. The results showed that the higher the VCO concentration, the higher the antioxidant activity. Antioxidan activity of Virgin Coconut Oil that is exposed to light decreased to 96.13%. The absorbance of VCO solution containing erythrosine as sensitizer decreased to 0.121 due to photooxidation. The conclusion of this study is that light will cause a photooxidation reaction, thereby reducing the antioxidant activity of VCO.
Co-Authors Clara A. Sengke Debora Tandi Dewa Gede Katja Edi Suryanto Edwin Paendong Fatimawali . Feti Fatimah Gabriela Clementine Ranti Gayatri Citraningtyas John Monintja Mamondol, Oktavianus Mercy Taroreh Miranti Aike Wemay Momuat, Lidya Novel Kojong Roreng, Matheda K Sherly Dawile