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All Journal B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Bintang Pendidikan Indonesia
Maulidatul Husna
Unknown Affiliation
Arts Dentistry Education Languange, Linguistic, Communication & Media Social Sciences

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HUBUNGAN ANTARA MATRIX METALLOPROTEINASE-13 DAN TISSUE INHIBITOR METALLOPROTEINASE-1 PADA PASIEN PERIODONTITIS KRONIS Maulidatul Husna; Nasution aini hariyani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.893

Abstract

Introduction:  Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting the teeth and that may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in the gingival crevicular fluid of chronic periodontitis patients and tissue inhibitor of metalloproteinase-1 (TIMP‐1) is an endogenous inhibitor of MMPs implicated in inflammation.  This review purpose to discuss the relationship between matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 in chronic periodontitis. Review: The level of MMP-13 plays a role in the pathogenesis of chronic periodontitis. MMP-13 (collagenase-3) is the third member of the collagenase subfamily of MMPs and it is a potent gelatinolytic and collagenolytic enzyme expressed by different cell types. The activity of these MMPs is primarily controlled by tissue inhibitors, known as TIMPs, which have an N-terminal domain that is able to inhibit MMPs. Some studies showed that MMP-13 is associated with soft and hard tissue damage during the progression of chronic periodontitis. The balance between MMPs and TIMPs plays an important role in the degradation of the extracellular matrix. In healthy periodontal conditions, TIMP levels are generally higher than in unhealthy conditions, in which MMP levels exceed the level of TIMP. Conclusion: Chronic periodontitis is characterized by the increase of MMP-13 expression during the progression of the disease, the active sites show a decrease of TIMP-1 levels in association with the elevation of MMP-13. 
Asbabun Nuzul Surah Al-Mujadalah Ayat 11 Dalam Perspektif Pendidikan di Pesantren Modern Darul Ihsan Maulidatul Husna; Dedi Masri; Muhammad Alfiansyah; Sri Wahyuni
Jurnal Bintang Pendidikan Indonesia Vol 1 No 3 (2023): Agustus : Jurnal Bintang Pendidikan Indonesia (JUBPI)
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jubpi.v1i3.1605

Abstract

This study aims to analyze thel asbabun nuzul of Q.S Al-mujadalah verse 11 which is rellated to the perspelctivel of education in the Modern Islamic Boarding School Darul Ihsan. Asbabun Nuzul surah Al-mujadalah versel 11 is about manners and morals when someone is in the assemby, so it is analyzed how the manners of the students or santri and santriwati in the Modern Islamic Boarding School Darul Ihsan when they are in the assemby. Asbabun Nulzul surah Al-mujadalah verse 11 is not only intended for students, but for all Muslims who are in an assemby of knowledge, both students and educators. such as the story when the Prophet opened an assemby and at that time the Badr came and no one gave him a seat, so the Prophet ordered other companions to gelt up and give a seat to the Badr who had just arrived, because whoever clears his seat during the assemby, Allah SWT will raise his degreel. This must be applied to students in all educational institutions and also in their daily lives, not spared from the students who study at boarding schools, adab and moras are the most important things that are seen and taught in pesantren, because in fact adab is higher than knowledge. So, for students who study in pesantren, it should bel emphasized to them about adab, especially when they are in the assemby of knowledge or in teaching and learning activities, adab used towards teachers, towards friends around and towards the boarding school environment.This research makes an important contribution in understanding the asbabun Nulzul of surah Al-mujadalah verse 11 in the perspective of education in the Modern Darul Ihsan Islamic Boarding School which is about adab when in the assemby, and the implication of this research is the importance and necessity of knowing how adab when in the assemby of knowledge for students.
Co-Authors Dedi Masri Muhammad Alfiansyah Nasution, Aini Hariyani Sri Wahyuni