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All Journal Dentika Dental Journal Journal of Dentistry Indonesia Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Interdental Jurnal Kedokteran Gigi (IJKG) JOURNAL OF APPLIED SCIENCE (JAPPS)
Nasution, Aini Hariyani
Department Of Periodontic, Faculty Of Dentistry, Universitas Sumatera Utara, Medan, North Sumatra
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Difference Upper Incisor and Upper Molar Alveolar Bone Loss between Smoker and Non-Smoker Patient with Chronic Periodontitis: Perbedaan Kehilangan Tulang Alveolar Gigi Insisivus dan Molar Rahang atas pada Pasien Periodontitis Kronis Perokok dan bukan Perokok Nasution, Aini Hariyani; Amalia, Martina; Tarigan, Cornelia Christy
Dentika: Dental Journal Vol. 22 No. 1 (2019): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.604 KB) | DOI: 10.32734/dentika.v22i1.269

Abstract

Periodontitis is one of most common oral disease. Chronic periodontitis is characterised by gingival inflamation, periodontal pocket, lost of attachment, and alveolar bone loss. Smoking is a risk factor of periodontal disease that has direct effect to periodontal tissue. Smoking prevalence in Indonesia during 2013 was about 56,7% among men and about 1,9% among women. Smoking modifies the periodontal microbial challenge and host cytokine levels. Some studies showed that smoker has greater alveolar bone loss than non-smoker, and teeth that have the greatest alveolar bone loss are incisor and followed by molar. The aim of this study is to know the upper incisor and upper molar alveolar bone loss differences between smoker and non-smoker patient with chronic periodontitis. The study’s samples are 92 chronic periodontitis statuses and 200 periapical radiographs that selected by purposive sampling techinque. This study will measure the distance between cementoenamel junction to alveolar bone crest, cementoenamel junction to tooth apex, and alveolar bone loss percentage at upper incisor and upper molar. To compare the differences upper incisor and upper molar alveolar bone loss at patient with chronic periodontitis between smoker and non-smoker will be analyzed by independent t test and Mann-Whitney U test. The result showed that smoker has greater alveolar bone loss than non-smoker. There is no significant differences at upper incisor alveolar bone loss and there is significant differences at upper molar alveolar bone loss between smoker and non-smoker patient with chronic periodontitis.
QUANTIFICATION OF STREPTOCOCCUS SANGUINIS ISOLATED FROM DENTAL PLAQUE AND SALIVA OF SUBJECTS WITH AND WITHOUT CORONARY HEART DISEASE – ANALYSIS USING REAL-TIME PCR: KUANTIFIKASI STREPTOCOCCUS SANGUINIS YANG DIISOLASI DARI PLAK DAN SALIVA GIGI SUBYEK DENGAN DAN TANPA PENYAKIT JANTUNG KORONER DENGAN MENGGUNAKAN PCR REAL-TIME Nasution, Aini Hariyani; Kemal, Yulianti; Lessang, Robert; Bachtiar, Boy
Dentika: Dental Journal Vol. 20 No. 1 (2017): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.018 KB) | DOI: 10.32734/dentika.v20i1.645

Abstract

Coronary Heart Disease (CHD) is the major cause of death in most countries in the world. Gram-positive and Gram-negative bacteria have been identified in bacteremia cases and known to have a role in various vascular diseases, including Streptococcus sanguinis which is most frequently isolated from endocarditis patients and often associated with CHD. The purpose of this study was to analyze the number of Streptococcus sanguinis isolated from dental plaque and saliva of subjects with and without CHD. Bacterial colonies isolated from the dental plaque and saliva of 16 subjects without CHD and 8 subjects with CHD were planted in Mitis salivarius agar, and then the DNA was extracted and quantified with a Real-Time PCR technique using 16S rRNA specific primers. The quantification of Real-Time PCR showed that there was a difference in the number of S. sanguinis between the two groups of subjects, but an unpaired T-test showed that the difference was not statistically significant. Furthermore, the number of S. sanguinis from dental plaque in CHD subjects tends to be higher than that of non-CHD subjects whereas the number of S. sanguinis from saliva in non-CHD subjects tends to be higher than that of CHD subjects.
Hydroxyapatite synthesize from Pugilina cochlidium and Babylonia spirata, L shells as bone graft materials candidates in periodontics Aini Hariyani Nasution; Rini Octavia Nasution; Desy Marlyn Situmorang; Andrie Harmaji
JOURNAL OF APPLIED SCIENCE (JAPPS) Vol 3, No 1 (2021): Journal of Applied Science (JAPPS)
Publisher : Institut Teknologi Sains Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36870/japps.v3i1.200

Abstract

Hydroxyapatite has been widely used as bone graft materials in periodontics. However, hydroxyapatite is still considered costly, and many of them are imported. Hydroxyapatite manufacturers from natural sources could be an affordable alternative for periodontal regeneration therapy. Pugilina cochlidium and Babylonia spirata, L are the natural sources with high calcium carbonate. The two clamshells are easily found in Indonesia but their usage is still limited as hydroxyapatite materials. This study aims to synthesize the hydroxyapatite with sol-gel method from Pugilina cochlidium and Babylonia spirata, L as bone graft materials candidates.
Association between age, gender and education level with the severity of periodontitis in pre-elderly and elderly patients Pitu Wulandari; Dody Widkaja; Aini Hariyani Nasution; Armia Syahputra; Gebby Gabrina
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 1 (2022): March 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i1.p16-20

Abstract

Background: As individuals grow older, they may be more susceptible to chronic diseases, which can affect their overall health. Periodontitis, for instance, is one of the most common oral diseases that result from prolonged exposure to pathogens. The main etiology of periodontitis is dental biofilms, but several risk factors may also affect the progression of the disease. Purpose: The study aimed to determine whether there was an association between age, gender and education level and the severity of periodontitis using the 2017 American Academy of Periodontology (AAP) classification. Methods: A retrospective analytical study was used to determine the stage and grade of periodontitis in relation to age, gender and education level. Secondary data in the form of medical record status was analysed using software applications. Results: The distribution of periodontitis was 66.7% in pre-elderly patients (45–59 years), 61.5% in male subjects and 39.7% in individuals with middle education levels. Using chi-square analysis, the severity of periodontitis showed a statistically significant correlation with age (p=0.01) and gender (p=0.003). In contrast, the level of education was not statistically correlated to the severity of periodontitis (p=0.887). The percentage of stage IV grade B was highest in elderly patients (65.38%), while stage IV grade C was the highest in male subjects (41.67%). Conclusion: The study showed that age and gender significantly influenced the occurrence and severity of periodontitis, while education level showed the opposite.
HIDROKSIAPATIT SEBAGAI SALAH SATU BAHAN YANG PALING UMUM DIGUNAKAN PADA CANGKOK TULANG: TINJAUAN PUSTAKA Amalia Leni; Nasution Aini Hariyani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.894

Abstract

Introduction: A bone graft is a bone substitute material that has been widely used in bone grafting. In general, a bone graft can be resorbable and replace normal bone in the healing process within a few months, because in principle the bone graft has the nature of osteoconduction, osteoinduction, and osteogenic. One of the synthetic materials commonly used in the bone graft is hydroxyapatite (HA), which is identical to the crystal structure of hydroxyapatite from the bone. Review: Hydroxyapatite is a synthetic bone graft, which is the most used now due to its osteoconduction, hardness, and acceptability by bone. Hydroxyapatite with a general formula of Ca10(PO4)6OH2 is much similar to an inorganic component of bone matrix. HA is one of the most stable and less-soluble calcium phosphate bioceramics with a Ca/P ratio of 1.67. Synthetic versions of bone apatite have been developed to address the demand for autologous bone graft substitutes. Synthetic HA is stiff and strong, but brittle. Some solutions to this problem are to combine HA with collagen, β-tricalcium phosphate (β- TCP), Calcium phosphate (CaP) Conclusion: Hydroxyapatite is well known for bone regeneration through conduction or by acting as a scaffold for filling of defects from ancient times, but emerging trends of osteoinductive property of HA are much promising for new bone regeneration.
HUBUNGAN ANTARA MATRIX METALLOPROTEINASE-13 DAN TISSUE INHIBITOR METALLOPROTEINASE-1 PADA PASIEN PERIODONTITIS KRONIS Maulidatul Husna; Nasution aini hariyani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 8, Nomor 2, September 2021 (Special Edition)
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v8i2.893

Abstract

Introduction:  Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting the teeth and that may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in the gingival crevicular fluid of chronic periodontitis patients and tissue inhibitor of metalloproteinase-1 (TIMP‐1) is an endogenous inhibitor of MMPs implicated in inflammation.  This review purpose to discuss the relationship between matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 in chronic periodontitis. Review: The level of MMP-13 plays a role in the pathogenesis of chronic periodontitis. MMP-13 (collagenase-3) is the third member of the collagenase subfamily of MMPs and it is a potent gelatinolytic and collagenolytic enzyme expressed by different cell types. The activity of these MMPs is primarily controlled by tissue inhibitors, known as TIMPs, which have an N-terminal domain that is able to inhibit MMPs. Some studies showed that MMP-13 is associated with soft and hard tissue damage during the progression of chronic periodontitis. The balance between MMPs and TIMPs plays an important role in the degradation of the extracellular matrix. In healthy periodontal conditions, TIMP levels are generally higher than in unhealthy conditions, in which MMP levels exceed the level of TIMP. Conclusion: Chronic periodontitis is characterized by the increase of MMP-13 expression during the progression of the disease, the active sites show a decrease of TIMP-1 levels in association with the elevation of MMP-13. 
Comparison of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 levels and alveolar bone density in chronic periodontitis before and after scaling and root planning Aini Hariyani Nasution; Lidya Irani Nainggolan; Widianto Meydhyono
Majalah Kedokteran Gigi Indonesia Vol 8, No 2 (2022): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.66221

Abstract

Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue is caused by an imbalance between matrix metalloproteinases and their inhibitors. Decreased tissue inhibitor and elevated matrix metalloproteinase levels result in collagen connective tissue and bone degradation. Several studies have shown that high levels of matrix metalloproteinase-13 (MMP-13) and low levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) are also found in gingival crevicular fluid and saliva of patients with periodontitis. The purpose of this study was to determine the comparison of MMP-13 levels, TIMP-1 levels of saliva and bone density in patients with chronic periodontitis before and after scaling and root planning (SRP). The study samples were selected from patients who came for treatment at the Periodontics Installation of Universitas Sumatera Utara. A total of 16 patients were selected (n = 16) with a diagnosis of chronic periodontitis. The result showed that salivary MMP-13 levels in chronic periodontitis patients before SRP were higher than salivary MMP-13 levels after SRP and the difference was statistically significant (p < 0.05). It was also revealed that salivary TIMP-1 levels and alveolar bone density in chronic periodontitis patients before SRP were lower than that after SRP and the difference was statisticallysignificant (p < 0.05). There was a positive correlation between clinical parameters and salivary MMP-13 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05). There was a negative correlation between clinical parameters and salivary TIMP-1 levels in patients with chronic periodontitis before and after SRP, but it was not statistically significant (p > 0.05).
Inhibitory test of andaliman (Zanthoxylum achantopodium DC) extract mouthwash against dental plaque bacteria Martina Amalia; Priscillia Sekar Yosuana; Iqlima Salsabila binti Mohammad; Filya Suri Risky Nababan; Zulkarnain; Pitu Wulandari; Aini Hariyani Nasution; Armia Syahputra
Dental Journal Vol. 56 No. 2 (2023): June 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i2.p92-97

Abstract

Background: Andaliman (Zanthoxylum achantopodium DC) is an endemic plant that is found in the province of Sumatera Utara, Indonesia. It contains secondary metabolites, such as alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids, which can potentially be used as a mouthwash. Streptococcus sanguinis and Staphylococcus aureus are the primary colonizing bacteria in plaque formation. Bacterial plaque is known to be the main cause of periodontal disease but can be controlled mechanically and chemically using mouthwash. Purpose: To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of andaliman extract mouthwash (2%, 4%, 8%) against Streptococcus sanguinis ATCC®10556™ and Staphylococcus aureus ATCC® 25923™. Methods: This is a laboratory study with a post-test control-only design. The sample consists of andaliman extract mouthwash (2%, 4%, 8%), a positive control (chlorhexidine gluconate 0.2%), and a negative control (mouthwash formulation without andaliman extract) with three repetitions for each group. Data were analyzed with the one-way ANOVA test and post hoc LSD test. Results: The andaliman extract mouthwash with concentrations of 2%, 4%, and 8% significantly reduced the number of Streptococcus sanguinis and Staphylococcus aureus colonies (p<0.05), and there was a significant difference in the andaliman extract mouthwash with concentrations of 2%, 4%, and 8% compared to the negative control. Conclusion: Andaliman extract mouthwash with a concentration of 8% was more effective in inhibiting Streptococcus sanguinis growth than Staphylococcus aureus. The MIC values for both bacteria were 2%, but the study could not determine the MBC value.
THE EFFECTIVENESS OF PLATELET RICH FIBRIN, CONNECTIVE TISSUE GRAFT AND THEIR COMBINATION IN THE CLOSURE OF GINGIVAL RECESSION: A SYSTEMATIC REVIEW Dian Anggraini; Irma Ervina; Aini Hariyani Nasution
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 20 No. 1 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v20i1.7866

Abstract

Introduction: Connective Tissue Graft (CTG) is one of the techniques in gingival recession treatment, but considering the morbidity of using CTG, biomaterials such as Platelet Rich Fibrin (PRF) can be an alternative in gingival recession closure treatment. This systematic review aims to compare and evaluate the use of PRF, CTG and their combination in gingival recession closure. Review: An electronic literature search in Medline (PubMed), Google Scholar, and Elsevier (Sciencedirect) was conducted to identify Randomized Clinical Trial (RCT) reporting on the treatment of gingival recession using PRF, CTG or a combination of both from 2018 to 2023 in English. This systematic review was conducted following the Preferred Reporting Items for Systematic review (PRISMA) guidelines. The parameters assessed in the RCTs were: recession depth (RD), clinical attachment level (CAL), keratinized gingival width and height (KTW, KTH), probing depth (PD), gingival thickness (GT) and patient discomfort after surgery assessed by VAS (Visual Analog Scale). Based on the 1,152 articles retrieved, there were only five RCTs eligible for systematic review. Four articles compared the use of PRF with CTG, and one article compared the use of CTG with the combination of CTG + PRF in gingival recession closure. Conclusion: The use of PRF, CTG, and a combination of both were effective in closing gingival recession. The use of CTG gave better results in increasing gingival thickness and keratinized gingival width compared to the use of PRF, but the combination of CTG and PRF gave significant results in keratinized gingival height and decreasing recession depth compared to the use of CTG alone. Thus, the combination of CTG and PRF may be a more promising gingival recession closure treatment option.
The Role of Occlusal Adjustment on Treatment of Tooth’s Mobility: Case Report Cut Ati Ningsih; Irma Ervina; Aini Hariyani Nasution
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 20 No. 2 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v20i2.9521

Abstract

Introduction: Periodontal disease and traumatic occlusion can result in loss of alveolar bone so that the teeth become mobile. Treatment of tooth’s mobility depends on the etiology and prognosis of the tooth. Case: This case report describes the treatment of a tooth’s mobility due to periodontal disease and traumatic occlusion. The first case was a 39-year-old female patient with complaints of mobility of teeth, the gums of the lower front teeth were often swollen, pus intermittently since 2 years ago. Clinical examination showed tooth 41 mobility grade 2 with a pocket depth of 6 mm and teeth 31,32,42 mobility grade 1 with a pocket depth of 3 mm and were traumatic occlusion on teeth 11,21 and 41. Radiographic showed infrabony defects of teeth 31 and 41 with 30% bone loss. The second case was a 22-year-old female patient with complaints of bleeding gums when brushing her teeth and mobility of lower front teeth since 1 year ago. Clinical examination showed teeth 31,41 mobility grade 2 with a pocket depth of 4 mm and 6 mm, teeth 32,42 mobility grade 1 with a pocket depth of 3 mm, there was traumatic occlusion on teeth 21 and 31. Radiographic showed suprabony defects on teeth 31 and 41 with 30% bone loss. Case Management: In both cases, initial treatment was carried out with scaling and root planing, followed by occlusal adjustment. One week post-treatment oclusal adjustment there was no tooth mobility in either case. Discussions: Mobility can be caused by periodontal tissue inflammation, alveolar bone destruction, and traumatic occlusion. Conclusion: Occlusal adjustment can reduce mobility in traumatic occlusal teeth.
Co-Authors Amalia Leni Amalia, Martina Andrie Harmaji Armia Syahputra Boy Bachtiar Budi Budi Cut Ati Ningsih Desy Marlyn Situmorang Dian Anggraini Dody Widkaja Filya Suri Risky Nababan Gebby Gabrina Iqlima Salsabila binti Mohammad Irma Ervina Kurmaena, Iceu Estu Lidya Irani Nainggolan Martina Amalia Maulidatul Husna Nevi Yanti Nurcahyanti, Hesty Pitu Wulandari Priscillia Sekar Yosuana Rini Octavia Nasution Robert Lessang Tarigan, Cornelia Christy Wenny Dewanti, Wenny Widianto Meydhyono Yulianti Kemal Zulkarnain