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All Journal Jurnal Respirologi Indonesia
Yani Jane Sugiri
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Brawijaya
Health Professions Medicine & Pharmacology

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Factors Affecting the Treatment Success of Short-Term Regimen for Drug Resistant Tuberculosis (DR TB) Patients at Dr. Saiful Anwar General Hospital Malang Fahmi Adhi Prasetya; Yani Jane Sugiri; Teguh Rahayu Sartono; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.360

Abstract

Background: Tuberculosis/TB is a major health problem in the world. Indonesia ranks 3rd in TB cases and 7th in drug resistant (DR) TB cases in the world. In 2016, WHO recommended short term (9–11 month) regimen treatment with a success rate of 84% in several Asian and African countries. The purpose of this study was to determine factors that influence the success and failure of treatment using short-term regimen for DR TB patients at Dr. Saiful Anwar General Hospital Malang.Methods: This was an analytic observational study with retrospective cohort design on 85 short-term regimen DR TB patients who started treatment on October 1, 2017 to September 30, 2018 at the DR TB ward of Dr. Saiful Anwar General Hospital Malang. Data analysis used chi square test with alternative fisher exact test and logistic correlation test.Results: Education level had a significant correlation with treatment success (P=0.036; OR=2.746; CI 95%=1.053-7.165) while Pre XDR TB sputum drug susceptibility test had a significant correlation with treatment failure (P=0.037; OR=1.556; CI 95%=1.180-2.050). Based on logistic correlation test, the predictive variables for treatment outcomes were age, education, criteria for suspected DR TB and drug susceptibility test results of pre XDR TB.Conclusion: The level of education affected the success treatment of DR TB short-term regimen. The results of Pre XDR TB sputum drug susceptibility test influenced the failure of DR TB short-term regimen.
The Effect of N-Acetylcysteine as Adjuvant Therapy of Hypoxemia in COVID-19 Patients, Assessed by Interleukin-6 Level and PaO2/FiO2 Ratio Simon Petrus Hardiyanto Rumaratu; Ngakan Putu Parsama Putra; Yani Jane Sugiri; Susanthy Djajalaksana; Aditya Sri Listyoko; Harun al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.227

Abstract

Background: Interleukin 6 (IL-6) is a cytokine that plays an essential role in lung damage and mortality. Arterial-to-inspired oxygen (PaO2/FiO2) ratio, also known as the Horowitz index, is a measure of hypoxemia in respiratory failure. N-Acetylcysteine (NAC) might be helpful in managing coronavirus disease 2019 (COVID-19) patients by decreasing the cytokine storm, which will lead to a decrease in disease severity. This study aims to analyze the effect of NAC as adjuvant therapy on IL-6 level and PaO2/FiO2 ratio in COVID-19 patients.Methods: This is a quasi-experimental, non-equivalent control group designed study of confirmed COVID-19 patients moderate to critical in Saiful Anwar Hospital Malang. Seventy-five patients received NAC intravenously 5000mg/72 hours as adjuvant therapy for seven days, and 16 subjects in the control group. IL-6 level and PaO2/FiO2 ratio were measured on day one and day 8 in both groups from blood samples. Wilcoxon, Mann-Whitney U Test, and Pearson correlation were conducted for statistical analysis.Results: The decrease in IL-6 level on days 1 to 8 in the NAC group is significantly lower (94.49±253.51) than in the control group (P=0.002). The increase in PaO2/FiO2 ratio from day 1 to day 8 in the NAC group is significantly improving (126.94±76.05), the same as the control group (P<0.001). There is a weak correlation between IL-6 level and PaO2/FiO2 ratio after administration of NAC (r=0.154, P=0.186).Conclusion: There is a significant decrease in IL-6 level after administration of NAC. NAC has no significant effect on hypoxemia in COVID-19 patients.
Co-Authors Aditya Sri Listyoko Fahmi Adhi Prasetya Harun al Rasyid Harun Al Rasyid Ngakan Putu Parsama Putra Simon Petrus Hardiyanto Rumaratu Susanthy Djajalaksana Teguh Rahayu Sartono