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All Journal Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Pengabdian Masyarakat dalam Kesehatan Journal of Community Health and Preventive Medicine (JOCHAPM)

Aditya Sri Listyoko

Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia

Author-ID : 3604917

Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Articles

Effect of Giving Polyphytopharmaca on Improvement in The Degree of Asthma Control through Reduction of Eosinophils and Interleukin-13 Uncontrolled Asthma Patients Aditya Sri Listyoko; Iin Noor Chozin; Susanthy Djajalaksana
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.109

Backgrounds: Bronchial asthma is a heterogeneous disease characterized with chronic airway inflammation. The level of asthma control is an indicator of asthma management outcomes. It is influenced by a complex immunological mechanism, included the role of IL-13 as a key biomarker of inflammation. We investigate the effect of Poly-Phytopharm (Kleinhovia hospita 100 mg, Curcuma xanthorriza 75 mg, Nigella sativa 100 mg and Ophiocephalus striatus 100 mg) on the level of asthma control tests (ACT) score, blood eosinophils, and serum IL-13 on not fully controlled asthma stable patients. Methods: This study used quasi-experimental pre and post test methods, in 15 stable asthma patients who were not fully controlled at the pulmonary outpatient clinic of Dr. Saiful Anwar General Hospital, Malang. Assessment of ACT score, blood eosinophils, and serum IL-13 are carried out before and after supplementation of Poly-Phytopharm three times a day, two capsules respectively for 12 weeks. The ACT was scored by the investigator by direct questioning of patients, the blood eosinophil was measured with blood analysis, and the IL-13 in serum was detected with qPCR method. Results: There is significant increase of ACT score (18.07±2.57 to 22.06±1.83; P=0.001). In subject with baseline eosinophils ≥300 pg/mL (n=9), there were significant reduction in blood eosinophils (653.15±276.77/µL to 460.66±202.04/µL; P=0.038), and a decrease of serum IL-13 (17.69±9.901 pg/ml to 16.17±12.438 pg/ml; P=0.609). Conclusions: The administration of poly-phytopharm for 12 weeks improves ACT level, decreases blood eosinophils, and decrease serum IL-13 on not fully controlled asthma stable patients. (J Respir Indo. 2020; 40(3): 130-8)

Analysis of Comorbidity and Its Association with Disease Severity and Mortality Rate in Hospitalized COVID-19 Patients Anthony Christanto; Aditya Sri Listyoko; Ngakan Putu Parsama Putra
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.278

Background: Comorbidity is a major factor in determining the outcome of COVID-19. However, existing studies regarding comorbidities and the disease severity and mortality of COVID-19 are mostly based on studies in the whole community, and not on those admitted to hospitals. This study aims to determine the demographic profile of comorbidities among COVID-19 patients hospitalized in tertiary care referral hospitals and its association with disease severity and mortality. Methods: We analyzed the data from 60 laboratory-confirmed patients in our hospital in Malang City, East Java, Indonesia from March 12th, 2020 to June 5th, 2020. We describe the demographic profile of the patients and perform statistical analysis to determine its relationship to disease severity and mortality. Results: The majority of the study samples (66.7%) were categorized as having a severe disease. Thirty-seven samples (61.7%) had at least one comorbidity. The mortality rate among the study population is 30.0%, and 37.8% among those with comorbidities. The most prevalent comorbidity was hypertension (40.0%), followed by heart failure (35.0%) and diabetes (25.0%). There is a statistically significant relationship between the presence of comorbidities and disease severity and between disease severity and mortality (p<0.05). Diabetes was the only comorbidity with a significant relationship towards mortality in our study (p<0.05, OR 4.0 95% CI 1.16-13.74). Conclusion: Comorbidities are associated with worse disease severity and death in hospitalized COVID-19 patients.

The Use of Mask in Respiratory Exercise in the Era of COVID-19 Pandemic Susanthy Djajalaksana; Aditya Sri Listyoko; Lucky Togihon Harjantho; Anthony Christanto; Silvy Amalia Falyani; Akira Yamasaki
Jurnal Respirasi Vol. 8 No. 2 (2022): May 2022
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: The 2019 Coronavirus Disease (COVID-19) pandemic causes public health protocols to be strictly enforced. This study examined the effect of using masks on performing exercises, particularly respiratory exercises, in the era of COVID-19 pandemic. Methods: A total of 24 people participated in this study using randomization and cross-over techniques. The variables measured were respiratory rate, oxygen (O2) saturation, pulse rate, carbon monoxide (CO) levels, and fatigue scale using the Borg Breathless Score. The statistical test used independent t-test, Wilcoxon, and Mann-Whitney U with a different level of p < 0.05. Results: There was no significant difference between the observed parameters (heart rate, respiratory rate, peripheral O2 saturation, CO levels, and Borg scale) in the groups using masks and not using masks. Conclusion: The increase in pulse rate, respiratory rate, and Borg Scale in the aerobic phase of respiratory exercise is physiological and can improve significantly after the cooling phase.

The Diagnostic Value of Platelet Count and MPV in Suspected COVID-19 Patient at Dr. Saiful Anwar Hospital Agustin Iskandar; Aditya Sri Listyoko; Hambiah Hari Oki
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1870

COVID-19 is a disease caused by SARS-CoV-2. Haematology alterations like lymphopenia is common, but not much study involves about thrombocyte. Incidence of thrombocytopenia in COVID-19 patient is 5-53.6%. Purpose of this study is to analyze diagnostic value of thrombocyte count and MPV in COVID-19. Cross sectional design took place at Dr. Saiful Anwar Hospital on March-June 2020. Data was taken at first admission. Confirmation test with SARS-CoV-2 gene detection with RT-PCR method. 115 patient suspected COVID-19 collected at the end of study with 69 positive and 46 negative. AUROC for thrombocyte is 0.336 (CI: 95%, 0.238 – 0.435, p= 0.01); MPV 0.488 (CI 95%, 0.378 – 0.598, p= 0.762). Thrombocyte count and MPV doesn’t have good diagnostic value for COVID-19. This might be due to different conditions that patient might had at admission. Thrombocytopenia and increased MPV often caused by hyperinflammatory condition and severe infection as mentioned in other study. Thrombocyte count and MPV alone can’t be used to diagnose COVID-19. Coincide use of other marker such inflammatory markers might be useful. Future study with larger sample and serial testing may needed to evaluate more about diagnostic value of thrombocyte count and MPV.

The Effect of N-Acetylcysteine as Adjuvant Therapy of Hypoxemia in COVID-19 Patients, Assessed by Interleukin-6 Level and PaO2/FiO2 Ratio Simon Petrus Hardiyanto Rumaratu; Ngakan Putu Parsama Putra; Yani Jane Sugiri; Susanthy Djajalaksana; Aditya Sri Listyoko; Harun al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.227

Background: Interleukin 6 (IL-6) is a cytokine that plays an essential role in lung damage and mortality. Arterial-to-inspired oxygen (PaO2/FiO2) ratio, also known as the Horowitz index, is a measure of hypoxemia in respiratory failure. N-Acetylcysteine (NAC) might be helpful in managing coronavirus disease 2019 (COVID-19) patients by decreasing the cytokine storm, which will lead to a decrease in disease severity. This study aims to analyze the effect of NAC as adjuvant therapy on IL-6 level and PaO2/FiO2 ratio in COVID-19 patients.Methods: This is a quasi-experimental, non-equivalent control group designed study of confirmed COVID-19 patients moderate to critical in Saiful Anwar Hospital Malang. Seventy-five patients received NAC intravenously 5000mg/72 hours as adjuvant therapy for seven days, and 16 subjects in the control group. IL-6 level and PaO2/FiO2 ratio were measured on day one and day 8 in both groups from blood samples. Wilcoxon, Mann-Whitney U Test, and Pearson correlation were conducted for statistical analysis.Results: The decrease in IL-6 level on days 1 to 8 in the NAC group is significantly lower (94.49±253.51) than in the control group (P=0.002). The increase in PaO2/FiO2 ratio from day 1 to day 8 in the NAC group is significantly improving (126.94±76.05), the same as the control group (P<0.001). There is a weak correlation between IL-6 level and PaO2/FiO2 ratio after administration of NAC (r=0.154, P=0.186).Conclusion: There is a significant decrease in IL-6 level after administration of NAC. NAC has no significant effect on hypoxemia in COVID-19 patients.

EMPOWERING TELEMEDICINE AS AN EFFORT TO ASSES KNOWLEDGE, ASTHMA SYMPTOMS CONTROL AND RISK FACTORS OF ASTHMATIC PATIENTS IN THE ERA OF COVID-19 PANDEMIC Aditya Sri Listyoko; Susanthy Djajalaksana; Ngakan Putu Parsama Putra; Ungky Agus Setyawan; Caesar Ensang Timuda; Jimmy Akbar; Simon Petrus; Maria Kristiani; Ulfah Kartikasari; Yenny Widowati
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 4 No. 2 (2022): OCTOBER 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v4i2.33504

Introduction: Asthma is heterogenous disease characterized by chronic airway inflammation. COVID-19 pandemic has an impact on health services where telemedicine could provide alternative method to evaluate patientâ€™s condition, reduce risk of infection and disease transmission. The aim of this study is to analysis knowledge, asthma symptoms control and risk factors among the asthmatic patients via telemedicine Methods: Data was obtained from telemedicine of 28 asthmatic patients in the context of community services. Inclusion criteria is stable asthmatic patients who conducted medical interview via videocall application. Cross sectional data were taken including demographic, knowledge of subjects, profile of subjects, and assessment of asthma symptoms control and assessment of poor outcomes. Data were analyzed descriptively and variables were analyzed using chi-square. Results: Subjects consisted of 28 stable asthmatic patients. The average of asthma onset was 17.96 years old. Clinically profile showed that 67.86% subjects were not routinely controlled, 64.29% had never performed pulmonary function test, 67.86% subjects didnâ€™t know the level of asthma control symptoms. Evaluation based on GINA symptoms control only 39.29% were in good control condition, 35.71% were partially controlled and 25% in uncontrolled condition. Use of inhaler device recently or previously prescribed on 67.86% subjects. Evaluation of knowledge about asthma still unsatisfactory, 67.86% subjects didnâ€™t know about their modifiable risk factors, 96.43% didnâ€™t know about written action asthma plan, 60.71% didnâ€™t know about asthma exercise. Self-medication was associated with poor asthma control (p=0,036) and knowledge about modifiable risk factors related to asthma symptoms control (p=0,041). Conclusion: Self-medication is related to uncontrolled asthma and knowledge of modifiable factors is related asthma symptoms control. It is important to educate the patient about the modifiable risk factors of asthma and how to manage it. Patient knowledge about their disease is still lacking, and there is a need for ongoing education to achieve good asthma control. Alternative intervention through telemedicine especially for continuing education and may therapeutic strategies can be performed as an effort to obtain well controlled asthma in community. Telemedicine, particularly in asthma management may benefit as an alternative approach of healthcare service in the context of pandemic era.

ANALYSIS OF KNOWLEDGE ON CHRONIC OBSTRUCTIVE LUNG DISEASE Susanthy Djajalaksana; Aditya Sri Listyoko; Maria Kristiani; Tiar Oktavian Effendi; Magdalena Sirait
Journal of Community Health and Preventive Medicine Vol. 2 No. 1 (2022): JOCHAPM Vol. 2 No. 1 2022
Publisher : Universitas Brawijaya

ABSTRAKBackground : Chronic obstructive pulmonary diseaseÂ (COPD) is a leading cause of morbidity, mortality and disability worldwide and represents a huge economical burden for the healthcare system. By knowing the level of public understanding of this disease, we were able to find out what education could be given to increase understanding about COPD. The aim of this study was to determine the level of knowledge of the non-medical and medical personnel about COPD.Methods : This is descriptive research. The research was conducted cross-sectionally with 200 respondents consisting of 100 medical subjects and 100 non-medical subjects. This research was carried out in the RSSA environment in November 2021. The data collection technique is that respondents filled out a Google Form.Results : The total score of the six categories showed that 73.875% of the medical group and 47.17% of the non-medical group already understood COPD. In all categories, the results of the analysis showing statistical significance (p<0.001).Conclusion : Our study shows significant knowledge about all knowledge of COPD between the general public and medical personnel.Suggestion : socialization to the public about COPD and the importance of the community getting to know COPD in preventive and treatment measures.Â Keywords: COPD, education, questionnaireÂ

THE ROLE OF SPIROMETRY AND ITS BENEFIT TO ASSESS RESPIRATORY SYMPTOMS IN THE SEMERU VOLCANIC ERUPTION COMMUNITY SERVICES Aditya Sri Listyoko; Susanthy Djajalaksana; Ngakan Putu Parsama Putra; Triwahju Astuti; Fitri Indah Sari; Nizzar Firdaus Trisnian; Silvy Amalia Falyani; Juwita Febriawati; Adinda Pramitra Permatasari; Claudia Herda Asyari
Journal of Community Health and Preventive Medicine Vol. 2 No. 2 (2022): JOCHAPM Vol. 2 No. 2 2022
Publisher : Universitas Brawijaya

Spirometry is a standard diagnostic tool for respiratory diseases. The people who live around the volcanic eruption may have a respiratory problems, both acute and chronic conditions. The aim of this study is to evaluate whether spirometry can be used as a diagnostic tool in the context of disaster in particular volcanic eruption. Data was obtained from medical examination in community services of Semeru volcanic eruption affected community in Pronojiwo, Oro Oro Ombo, Lumajang in last January 2022. Spirometry was performed for the patient who had a respiratory problems. Data was analyzed descriptively to assess lung function test using spirometry and its benefit in the people affected by volcanic eruption. Among the subjects, 77.27% had abnormal findings from the spirometry result. The mean of %VC, % FVC and % FEV1/FVC were 71.49%; 74.58%; 74.39% respectively. The result of spirometry revealed normal, restriction, and obstruction with suggestive restriction 18.18%; 22.73%; 31.82%; 22.73% respectively. The evaluation of spirometry parameters showed that 54.55% was appropriate for clinical diagnosis made by a physician. Our data show that most subjects had an abnormal results from spirometry. Spirometry may be a diagnostic tool can be used in natural disasters, particularly volcanic eruption for assessing respiratory symptoms.

The Diagnostic Value of Platelet Count and MPV in Suspected COVID-19 Patient at Dr. Saiful Anwar Hospital Agustin Iskandar; Aditya Sri Listyoko; Hambiah Hari Oki
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1870

COVID-19 is a disease caused by SARS-CoV-2. Haematology alterations like lymphopenia is common, but not much study involves about thrombocyte. Incidence of thrombocytopenia in COVID-19 patient is 5-53.6%. Purpose of this study is to analyze diagnostic value of thrombocyte count and MPV in COVID-19. Cross sectional design took place at Dr. Saiful Anwar Hospital on March-June 2020. Data was taken at first admission. Confirmation test with SARS-CoV-2 gene detection with RT-PCR method. 115 patient suspected COVID-19 collected at the end of study with 69 positive and 46 negative. AUROC for thrombocyte is 0.336 (CI: 95%, 0.238 – 0.435, p= 0.01); MPV 0.488 (CI 95%, 0.378 – 0.598, p= 0.762). Thrombocyte count and MPV doesn't have good diagnostic value for COVID-19. This might be due to different conditions that patient might had at admission. Thrombocytopenia and increased MPV often caused by hyperinflammatory condition and severe infection as mentioned in other study. Thrombocyte count and MPV alone can't be used to diagnose COVID-19. Coincide use of other marker such inflammatory markers might be useful. Future study with larger sample and serial testing may needed to evaluate more about diagnostic value of thrombocyte count and MPV.

aO2, SaO2, dan Rasio PaO2/FiO2 Sebagai Prediktor Derajat Keparahan Pasien COVID-19 Rawat Inap Ngakan Putu Parsama Putra; Aditya Sri Listyoko; Anthony Christanto
Majalah Kedokteran Indonesia Vol 70 No 12 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.12-2020-326

Introduction: Currently COVID-19 continues to show an increase in prevalence and mortality. Fever, dry cough, fatique and progression to dyspnea even respiratory failure and ARDS are the symptoms of COVID-19. “Happy hypoxia” is an indication that certain patients do not express breathlessness but have impaired oxygenation. It is important to determine the degree of oxygenation an all COVID-19 patients that will predict the severity of the disease and provide an outline of further management plans.Objective: This study aimed to describe the parameters of blood gas analysis in hospitalized patients and analyze its correlation with degree of severity of the diseaseMethods: We conducted observational analysis, cross sectional, single-center study including 71 laboratory-confirmed patients in Dr. Saiful Anwar General Hospital, Malang, Indonesia from April-Juni 2020. Statistical analysis was performed to determine the determine the relation of blood gas analysis with disease severity. Result: Subjects were divided to 25 patients (35,21%) in the mild-moderate group and 46 patients (64,79%) in severe group. Analysis of demographic and clinical characteristic showed that age, history of smoking, dyspnea and oxygen delivery were associated with disease severity (p less than 0,005). Statistical analysis of blood gas analysis showed associated degree of oxygenation with disease severity which is assessed by PaO2, SaO2 BGA, PaO2/FiO2 and original PaO2 (p less than 0,005). Conclusion: In our cross sectional study we found that degree of oxygenation was associated with disease severity in hospitalized COVID-19 patients.

Co-Authors Adinda Pramitra Permatasari Agustin Iskandar Akira Yamasaki Anthony Christanto Anthony Christanto Anthony Christanto Caesar Ensang Timuda Claudia Herda Asyari Fitri Indah Sari Hambiah Hari Oki Harun al Rasyid Iin Noor Chozin Jimmy Akbar Juwita Febriawati Lucky Togihon Harjantho Magdalena Sirait Maria Kristiani Maria Kristiani Ngakan Putu Parsama Putra Nizzar Firdaus Trisnian Setyawan, Ungky Agus Silvy Amalia Falyani Silvy Amalia Falyani Simon Petrus Simon Petrus Hardiyanto Rumaratu Susanthy Djajalaksana Susanthy Djajalaksana Susanthy Djajalaksana Tiar Oktavian Effendi Triwahju Astuti Ulfah Kartikasari Yani Jane Sugiri Yenny Widowati

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