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Achmad Furqon
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Health Professions Medicine & Pharmacology Public Health

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Metastasis Kanker Paru: [Lung Cancer Metastatic] Anna Febriani; Achmad Furqon
Jurnal Respirasi Vol. 4 No. 3 (2018): September 2018
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (773.163 KB) | DOI: 10.20473/jr.v4-I.3.2018.94-101

Abstract

Metastasis is the ability of cells to escape from the primary tumor, then enter the circulation to the distant tissue and form a secondary tumor. There are hemodynamic hypothesis (anatomical) and seed and soil hypothesis (molecular recognition). Tumor cells spread through several ways: percontinuitatum, lymphogen, hematogenous, transluminal, transcelomic, and iatrogenic. The stages of the metastasis process include: detachement, invasion, intravasation, circulation, extravasation, and angiogenesis. Predilection of lung cancer metastasis often happens in the brain, bones, liver, and adrenal glands. The spread of lung cancer metastasis to the brain, bone, and liver occurs hematogenously. Adrenal glands metastasis ipsilateral occurs lymphatically, while contralateral occurs hematogenously. Lung cancer is often diagnosed at an advanced stage, because in the early stage it is often asymptomatic. Metastasis of lung cancer to distant organs is the most cause of lung cancer deaths.
Co-Authors Anna Febriani