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All Journal Majalah Kesehatan Pharmamedika Jurnal Health Sains Jurnal Locus Penelitian dan Pengabdian Research Horizon
Akbar Wibriansyah
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Aerospace Engineering Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Uji Toksisitas Akut Ekstrak Etanol Sarang Semut (Myrmecodia pendens) Kalimantan pada Mencit (Mus musculus) Swiss Mart Hindrasyah Pandia, Dhayu; Wibriansyah, Akbar; Pratiwi, Widya; Fajrin Priadinata, Akhmad; Sari, Wening
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.433

Abstract

Sarang semut (Myrmecodia pendans) is an Indonesian native plant that has been used in folk medicine. Researches showed sarang semut has antioxidant effect,  xantinoxidase inhibitor potency, and anticancer activity. The efficacy and safety of this plant should have been proven before used in modern medicine. The objective of this research was to assess the potency of acute toxicity, evaluate toxic clinical symptoms and histopahtologic examination. The research was completly randomized design. The treated animal was 20 Swiss male mice devided into 5 groups; 1 control group with administration of 1% NaCMC  and 4 experimental groups with dosage administration of ethanol extract of sarang semut were 0,1, 1, 10 and 100g/Kg of body weight respectively. Evaluation of the toxic clinical symptoms and death was done in 24 hours and 14 day for survival mice. The test resulted LD50 of ethanol extract of sarang semut was 3,162g/Kg of body weight. All mice in 10 and 100g/kg of body weight groups were death in one hour administration of extract and showed toxic clinical symptom such as hyperactive and convulsion. Histopathologic examination on kidney of the death mice was showed infiltration of inflammation cells and congestive tubules diffuse . The ethanol extract of sarang semut was a slighly toxic substance for Swiss male mice based on Hodge dan Sterner criteria.
Legal Protection for Consumers Against Hazardous Skincare Products Wiyardhani, Laras; Wibriansyah, Akbar; Payuti, Yuyut
Research Horizon Vol. 5 No. 3 (2025): Research Horizon - June 2025
Publisher : LifeSciFi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54518/rh.5.3.2025.658

Abstract

The proliferation of unregistered skincare products in Indonesia presents a critical legal issue concerning consumer safety and regulatory enforcement. Despite the presence of Law Number 8 of 1999 on Consumer Protection, the circulation of unauthorized cosmetics continues to endanger public health and disrupt market order, as evidenced by national agency of drug and food control 2024 data reporting over 1,000 confiscated illegal products valued in the tens of billions of rupiah. This research addresses the legal question of how effectively current consumer protection laws safeguard individuals from the risks posed by illegal skincare products. The study aims to analyze the normative foundation of consumer protection, evaluate enforcement challenges, and propose strategies to enhance regulatory efficacy. Using a normative juridical method, the research relies on statutory analysis, case studies, and conceptual interpretation based on primary, secondary, and tertiary legal sources. The findings reveal that although the legal framework is normatively adequate, its implementation is hindered by low public awareness, limited digital oversight, and fragmented institutional coordination. The study concludes by recommending integrated digital supervision, strengthened inter-agency collaboration, and continuous consumer legal education as essential measures to reinforce legal protection and curb the spread of unauthorized skincare products in Indonesia.
Comparison of the of Operative Treatment and Sclerotherapy Injection in the Management of Hemorrhoids: A Meta-Analysis of Randomized Controlled Trials Wiyardhani, Laras; Sander, Tara; Wibriansyah, Akbar
Jurnal Health Sains Vol. 6 No. 9 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i9.2695

Abstract

Rubber-band ligation (RBL) and sclerotherapy are the two most widely used office-based interventions for symptomatic haemorrhoidal disease, yet their comparative benefits remain uncertain. This systematic review and meta-analysis evaluated the relative efficacy and safety of sclerotherapy versus operative treatments (primarily RBL and excisional procedures). The primary objective of this systematic review and meta-analysis was to evaluate the relative efficacy and safety of sclerotherapy versus operative treatments (primarily RBL and excisional procedures) in the management of hemorrhoidal disease. Treatment success was 78.2% in operative arms (701/896) versus 74.1% with sclerotherapy (665/897); pooled RR = 1.03 (95% CI 0.91–1.17; I² = 85%), indicating non-inferiority of sclerotherapy. Recurrence in two trials (n = 302) showed lower recurrence after sclerotherapy (12.9%) than after operative treatment (28.4%); RR = 2.22 (95% CI 1.37–3.58; I² = 0%). Pain in three trials (n = 335) reported a higher risk of significant pain following operative procedures (RR = 1.17, 95% CI 1.02–1.34; I² = 60%) and greater mean pain intensity (SMD = 0.96, 95% CI 0.22–1.71; I² = 89%). Sclerotherapy achieves comparable short-term symptom control to operative treatments while offering superior durability and a more favorable pain profile. Given its minimal invasiveness and ease of repetition, modern sclerotherapy should be considered a first-line option for grade I–III haemorrhoids. High between-study heterogeneity underscores the need for standardized protocols and longer follow-up.
Building the Future of Brain Health: Establishing Neurovascular Services in Southeast Sulawesi Wibriansyah, Akbar; Adam, Achmad; Zulkifli, Bilzardy Ferry
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4248

Abstract

Background: Stroke and other neurovascular diseases are leading causes of death and disability worldwide, particularly in regions with limited healthcare resources. Southeast Sulawesi faces major challenges in providing adequate neurovascular care, including shortages in diagnostic facilities, specialists, and emergency response systems. Addressing these gaps is essential to improving patient outcomes and reducing healthcare disparities. Methods: A mixed-methods approach was employed, combining qualitative data from semi-structured interviews with healthcare providers, policymakers, and patients, with quantitative analysis of official health records and facility observations. The study period spanned from July 2021 to November 2024. Results: In a population of 2.74 million, stroke emerged as the second leading cause of death (17% of total mortality). Infrastructure assessment revealed critical gaps: only 11 of 21 referral hospitals (52.4%, CI 95%: 31.0-73.8%) had CT scanners, with no MRI facilities available. Human resources were severely limited, with only three neurosurgeons (1:914,667 population ratio) and fourteen neurologists (1:196,000). For hemorrhagic stroke cases, surgical intervention showed success rates ranging from 45.8% to 63.6%, with post-operative mortality rates of 15.7-20.8%. The average time to reach CT scan facilities was 4.2 hours (SD ±1.8), significantly exceeding optimal stroke management windows. Geographic and economic barriers further complicated access, with 68% of the population residing more than two hours from neurological care. Conclusions: This study identifies critical gaps in neurovascular service delivery while highlighting potential solutions through systematic infrastructure development, capacity building, and technological integration. The findings suggest that Southeast Sulawesi could develop an effective model for neurovascular care delivery in geographically challenged regions through targeted interventions and strategic resource allocation.
Co-Authors Achmad Adam Fajrin Priadinata, Akhmad Mart Hindrasyah Pandia, Dhayu Payuti, Yuyut Sander, Tara Wening Sari Widya Pratiwi Wiyardhani, Laras Zulkifli, Bilzardy Ferry