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All Journal Dinamika Hukum Majalah Kesehatan FKUB International Islamic Medical Journal
Budi Wicaksono
Jurusan Teknik Sipil FT. UNDIP Jl. Prof. Soedarto SH. Tembalang, Semarang 50275
Religion Humanities Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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EKSTRAK DAUN Nicotiana tabacum MENURUNKAN BERAT LEMAK VISCERAL PADA TIKUS DIABETES MELLITUS TIPE DUA Suprapto, Ratih Paramita; Jonathan, Andrew; Ernanda, Shelby A; Wicaksono, Budi
Majalah Kesehatan FKUB Vol 4, No 4 (2017): MAJALAH KESEHATAN FAKULTAS KEDOKTERAN
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.033 KB) | DOI: 10.21776/ub.majalahkesehatan.2017.004.04.2

Abstract

AbstrakDiabetes mellitus merupakan masalah utama kesehatan di dunia dan prevalensinya selalu meningkat. Pada dosis yang tepat kandungan nikotin dari ekstrak etanol daun tembakau (Nicotiana tabacum) memiliki efek hipoglikemik sehingga berpeluang sebagai terapi alternatif untuk diabetes mellitus. Namun, efeknya pada jaringan adipose penderita diabetes mellitus belum banyak diketahui. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak etanol daun tembakau terhadap berat lemak visceral tikus model diabetes mellitus. Pada penelitian ini tikus galur Wistar dibagi menjadi 5 kelompok yaitu kontrol negatif (K-), kelompok tikus model diabetes mellitus (K+), dan tiga kelompok tikus diabetes melitus yang diberi ekstrak etanol daun tembakau 90 (P1), 180 (P2) dan 270 (P3) mg/kgBB/hari per oral selama 28 hari. Hasil penelitian menunjukkan bahwa terdapat penurunan bermakna berat lemak pada semua kelompok tikus DM yang diberi ekstrak daun tembakau dibandingkan dengan tikus DM tanpa terapi maupun tikus normal (p < 0,05). Kesimpulan penelitian adalah pemberian ekstrak etanol daun tembakau menurunkan berat lemak visceral pada tikus model DM. Penurunan berat lemak visceral kemungkinan disebabkan oleh kandungan nikotin dalam ekstrak yang dapat mengaktivasi lipolisis, menghambat lipogenesis, aktivasi thermogenesis, dan penurunan intake makan.  Kata kunci: berat lemak visceral, diabetes mellitus, daun tembakau (Nicotiana tabacum).
PENEGAKAN HUKUM TERHADAP TINDAK PIDANA PEMBAKARAN HUTAN (Studi Kasus Putusan Nomor: 74/Pid.Sus/2015/PN.KAG) WICAKSONO, BUDI
Dinamika Hukum Vol 9 No 1 (2018): DINAMIKA HUKUM
Publisher : Dinamika Hukum

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Abstract

Pollution and environmental damage as in the case of environmental destruction burning Forest Area Conserfation/Forest Moratorium PT. Bumi Mekar Hijau (BMH) Simpang Tiga District Simpang Tiga Village, Tulung Selapan Subdistrict, Ogan Komering Ilir District, has had an impact on human life, such as global warming, flash floods, forest fires, landslides that cause both human and noneconomic resources of society, social and public facilities. Besides causing epidemics of dengue fever, muntaber, lungs and diarrhea and others. Based on this, the author wants to review through environmental crime. This study aims to examine law enforcement against criminal acts of forest burning and examine more appropriate criminal acts in Decision Number: 74/Pid.Sus/2015/PN.KAG. This study uses normative juridical type, the nature of the research is descriptive. Data source used secondary data. Technique of collecting data by conducting library research and document study on Decision Number: 74/Pid.Sus/ 2015/ PN.KAG. Analyze data by collecting data which then connected with existing problems and arranged in a systematic and logical. The results showed that law enforcement against defendant I. Kardomo Als Domo Bin Usup and defendant II. Ali Usman Bin Named for his actions which caused the destruction of the environment in the area of Conservation Forest / Moratorium Forest (protected forest) and Simpang Tiga Village Conservation Forest Simpang Tiga Village, Tulung Selapan Subdistrict, Ogan Komering Ilir Regency, namely :) were sentenced to imprisonment respectively for a period of 1 (one) year and a fine of Rp.250,000,000 (two hundred and fifty million rupiahs) provided that a fine is not paid is replaced with imprisonment for 3 (three) months. Based on the testimony of witnesses, evidence of letters and statements of the defendants and the existence of material evidence, the fact that the burning of land carried out by the defendants has caused a fire of 6100 hectares of land and caused the wood and grass trees on the land to burn up and cause smoke, resulting in pollution and/or destruction of the environment and existing evidence in the hearing, the appropriate criminal act in decision No. 74/Pid.Sus/2015/PN.KAG is a crime act of burning land/ forest. Keywords: Law enforcement, and burning Forest.
The Characteristic of Pregnancy in Woman with Rheumatic Mitral Stenosis in Dr. Soetomo Hospital Surabaya from 2015 – 2017 Relmasira, Joseph; Wicaksono, Budi
Jurnal Medis Islam Internasional Vol 2 No 1 (2020): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v2i1.1589

Abstract

Background: Cardiac disease is 1 of the major causes of maternal mortality. Mitral Stenosis (MS) is a particularly high-risk condition for a pregnant woman in emerging countries, the main cause of MS is a complication from rheumatic heart disease. Objective: To study the maternal and perinatal outcome of pregnancies complicated by mitral stenosis from rheumatic heart disease. Methods: We conduct a cross-sectional retrospective study using electronic medical data records in dr. Soetomo General Hospital over the period of 3 years from 2015 – 2017 involving 36 cases of pregnant women complicated by rheumatic mitral stenosis. The maternal and perinatal outcome was reviewed. Result: Most of the pregnant women with rheumatic mitral stenosis were at 29 - 34 weeks of gestational age. Majority of the patient (61,1 %) was in NYHA II classification for heart failure degree. The Degree of MS was moderate (75 %) and severe (25 %), with a maternal mortality rate was 4/36 patients (11,1 %), and all of the patients were with severe MS had class III/IV heart failure. The main reason for hospital admission was heart failure (50 %). 38 % of women with NYHA Class III/IV had severe MS. Most accompanying valve diseases occur at the patient with severe MS, with Tricuspid Regurgitation as the most accompanying valve disease (66,67 %) followed by Mitral Regurgitation (36,11 %) and Aortic Regurgitation (25 %). Percutaneous Transmitral Valve Commissurotomy (PTMC) was the chosen surgical intervention for valve correction. For a patient with Moderate MS, 6/8 (75 %) of the pregnancy terminated at ³ 34 weeks of gestational age, compared with 18/28 (64,28 %) patient with Severe MS the pregnancy terminated at < 34 weeks of gestational age. Cesarean section was the most chosen method of delivery for most of the cases. Fetal weight (4/7 cases) at delivery for Moderate MS was > 2500 g, compared with (7/18 cases) was < 2000 g for Severe MS. APGAR Score for Moderate MS cases was 8-10 for 5/7 cases, compared with Severe MS, 16/24 cases were < 8. Conclusions: Cardiac and obstetric complications from rheumatic mitral disease remain a major challenge in this disease. Early diagnosis and management with good adherent to pre-conceptional and prenatal care remain a key factor for preventing maternal and fetal morbidity and mortality.
Characteristics of PPROM in General Hospital Dr. Soetomo Surabaya Period September 2017 to September 2019 Alessandrini, Letizia; Wicaksono, Budi
Jurnal Medis Islam Internasional Vol 2 No 2 (2021): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v2i2.1838

Abstract

Background: Preterm Prelabour Rupture of Membranes (PPROM) is one of the causes of perinatal morbidity and mortality. Objective: To find out the characteristic of PPROM in Dr. Soetomo Hospital in September 2018 to September 2019. Method: A Retrospective Descriptive Study. The data came from the medical records of patients with PPROM who were included in the inclusion criteria. The exclusion criteria is all PPROM cases at Gestational age > 34 weeks. Result: The incidence of PPROM during September 2017 to September 2019 was 6.8% (175 patients), of which 152 patients included NBC cases and 23 patients with BC cases. Primipara 76 patients and Multipara 99 patients. For gestational age <26 weeks it was 17.1%, 26-30 weeks 29.7% and 31-34 weeks 53.1%. In this study, PPROM was amused 23.6%, underweight 3.1%, HBsAg 7.5%, HIV 7%, anemia 10.3%, Obesity 5.2%, Pragestational Diabetes 7.4%, Gestational Diabetes. 2,6%, preeclampsia 7,9% and severe preeclampsia 2,2%. The distribution of PPROM patients who received lung maturation was 72%, while the remaining 28% did not get lung maturation. Type of delivery for PPROM cases was vaginal delivery as much as 60% while 40% for cesarean section. Indications for vaginal delivery include fetal distress 25%, abnormal NST 18%, gemeli 17%, BSC 12%, febris 10%, pulmonary edema 5% and breech presentation 5%. The outcome distribution of PPROM infants born with asphyxia at birth was 87%. Weight of babies born with PPROM> 2500 g 4%, 1000-2500 g 73% and <1000 g 23%. The condition of the babies at birth with spontaneous breathing was 36 babies, nasal O2 was 13 babies and CPAP was 70 babies. The causes of death for preterm KPP babies included RDS 9 babies, Sepsis 4 babies and severe asphyxia 19 babies. The length of NICU care for infants who died with KPP Preterm mothers was <24 hours for 15 babies, 1-3 days 13 babies, 4-7 days 3 babies,> 7 days 3 babies and 5 fetuses were IUFD. 12 patients with PPROM received amnioinfusion while 5 patients with amniopatch, Outcome of infants from conservative PPROM who were treated with amniopatch or amnioinfusion obtained 6 babies died at birth, 8 babies with CPAP breath support, 1 baby with PCV breath support, 1 baby with ventilator and 1 infant spontaneously breathed. A total of 3 babies were outpatient after treatment for a maximum of ± 25 days. Conclusion: Perinatal care is currently experiencing some rapid progress, but the case of PPROM is still one of the biggest contributors to perinatal morbidity and mortality.
Co-Authors Achmad Salman Faridz, Achmad Salman Alessandrini, Letizia Ernanda, Shelby A Erry Gumilar Dachlan, Erry Gumilar Jonathan, Andrew Pariani, Siti Relmasira, Joseph Sudirman, Suryanti Suprapto, Ratih Paramita Widjiati Widjiati, Widjiati