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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya AgriHealth: Journal of Agri-food, Nutrition and Public Health
Mardhatillah Sariyanti
Department of Microbiology, Faculty of Medicine and Health Sciences, Bengkulu University, Bengkulu
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Public Health

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Trends in IgG Antibody Levels in Covid-19 Patients in Different Clinical Manifestations in Bengkulu City: Cohort Study Debie Rizqoh; Enny Nugrahaeni; Mulya Sundari; Dessy Triana; Mardhatillah Sariyanti; Nikki Aldi Massardi
AgriHealth: Journal of Agri-food, Nutrition and Public Health Vol 3, No 2 (2022): October
Publisher : Research and Development Center for Food, Nutrition and Public Health (P4GKM) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agrihealth.v3i2.61315

Abstract

More than two years have lasted since the coronavirus disease 2019 (Covid-19) pandemic. The case of Covid-19 in Indonesia has spread to all provinces and areas such as Bengkulu City. This study aims to determine the profile of clinical manifestations and antibody dynamics in Covid-19 patients in Bengkulu City. This study used a cohort design on Covid-19 patients at two Bengkulu City referral hospitals, M. Yunus Hospital and Harapan dan Doa Hospital. Data on clinical manifestations were obtained from the medical records of Covid-19 patients. Meanwhile, to determine the level of IgM and IgG antibodies, patient serum samples were taken directly from respondents from the beginning of hospital admission three times on the 1st, 2nd and 3rd weeks. Then the samples were examined by immunofluorescent assay method. The results of this study indicate that, in general, there are no significant differences in anti-SARS-CoV-2 IgG levels in Covid-19 patients in the 1st, 2nd and 3rd weeks of Covid-19 in Bengkulu City. The Spearman correlation test also showed no correlation between IgG levels and the clinical manifestations of Covid-19. Although not statistically significant, there was a trend towards differences in antibody levels in patients with mild, moderate and severe clinical manifestations. The results of this study indicate that there are variations in antibody dynamics in Covid-19 patients in Bengkulu City.
ANTIBODY IgG LEVELS AND ADVERSE EVENTS FOLLOWING IMMUNIZATION AFTER THIRD DOSE OF MODERNA VACCINE IN HEALTHWORKERS AFTER TWO DOSES OF SINOVAC VACCINE Ade Tiur Rumondang; Utari Hartati Suryani; Debie Rizqoh; Mardhatillah Sariyanti; Besly Sinuhaji
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 2 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i2.345

Abstract

Health Care Workers (HCWs) are a top priority to receive the vaccination for Coronavirus Disease 2019 (Covid-19). After two doses of the Sinovac vaccine as the primary vaccine, protection against Covid-19 weakens over time, so a booster vaccination is considered to produce more antibodies. In addition, each vaccine is inseparable from Adverse Event Following Immunization (AEFI). This study compares antibody levels and AEFIs between two doses of the Sinovac vaccine with the Moderna booster. This research is an observational analytic study with a cross-sectional study design and the sampling method is random sampling with a total of 74 HCWs using a consecutive sampling method. Samples that had received two doses of the Sinovac vaccine or booster doses of the Moderna vaccine after two doses of the Sinovac vaccine were included. Samples that had been infected with Covid-19 before vaccination were excluded. IgG antibody levels were measured using Chemiluminescent Microparticle Immunoassay (CMIA), while vaccine type and AEFI were gathered via questionnaire. The severity of AEFIs is based on WHO classification. The data analysis used the Mann- Whitney and Chi-Square tests with a 95% Confidence Interval (CI) to determine the relationship between variables. Twenty-nine subjects received two doses of the Sinovac primary vaccine (38.2%), and forty-five received the Moderna booster vaccine (59.2%). In booster doses of the Moderna vaccine recipients, antibodies tended to be higher, and the most common AEFIs were systemic. There was a significant difference in IgG antibody levels between recipients of two doses of the Sinovac vaccine (median=2888.8 AU/mL) and booster Moderna vaccine recipients (median=18081.04 AU/mL) (p=0.000, p <0.05). There were significant differences in AEFI in the groups receiving two doses of the Sinovac vaccine and those receiving the booster vaccine (p=0.000, p<0.05). This study concludes that there is a significant correlation between administering the Covid-19 vaccine and post-vaccination IgG antibody levels and AEFI.
Co-Authors Ade Tiur Rumondang Besly Sinuhaji Debie Rizqoh Dessy Triana Enny Nugrahaeni Mulya Sundari Nikki Aldi Massardi Utari Hartati Suryani