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All Journal Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Kedokteran Diponegoro Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL NASIONAL TEKNIK ELEKTRO The Indonesian Biomedical Journal Biomedical Journal of Indonesia Bioma : Jurnal Biologi Indonesia AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Kesehatan Tambusai Jurnal Kedokteran Raflesia Indonesian Journal of Multidisciplinary Science Dikdimas : Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy

Nikki Aldi Massardi

Universitas Bengkulu

Author-ID : 3120042

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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Sistem Peringatan Awal Resiko Preklamsia pada kehamilan menggunakan metoda Certainty Factor dan Android Fitrilina, Fitrilina; Albbi, M.; Agustian, Indra; Herawati, Afriyastuti; Massardi, Nikki Aldi
JURNAL NASIONAL TEKNIK ELEKTRO Vol 10, No 1: March 2021
Publisher : Jurusan Teknik Elektro Universitas Andalas

The mortality rate for pregnant women due to preeclampsia is still quite high in Indonesia in general and Bengkulu province in particular. There is no effective method to prevent preeclampsia, but early detection can help for proper treatment. Monitoring the condition of pregnancy is very important but the COVID-19 pandemic has prevented pregnant women to go to health facilities. Therefore, a pregnancy condition monitoring system was designed for early detection of preeclampsia using the android-based Certainty Factor method. The system designed consists of a blood pressure measuring device and an expert system. The device uses an MPX5500 pressure sensor, highpass Butterworth filter and an Arduino connected to an android smartphone via Bluetooth. The expert system will diagnose that pregnant women are at risk of preeclampsia or hypertension in pregnancy without the risk of preeclampsia. The blood pressure measuring Â device works with an average difference to the aneroid sphygmomanometer of 7.05 mmHg with an error of 6.24% at systolic pressure and 10.15 mmHg with an error of 13.13% at diastolic pressure. The result of expert system diagnosis has an accuracy of 91.45%. So it can be said that the designed system can be usedÂ Keywords : Preeclampsia, Blood Pressure Device, Certainty Factor MethodAbstrakAngka kematian Ibu hamil (AKI) karena preeklampsia masih cukup tinggi di Indonesia umumnya dan provinsi Bengkulu khususnya. Belum ada metoda yang efektif untuk mencegah terjadinya preeklampsia, tetapi deteksi dini dapat menolong untuk penanganan dan pengobatan yang cepat dan tepat. Monitoring kondisi kehamilan sangat penting, tetapi pandemi COVID-19 menyebabkan ibu hamil tidak dianjurkan untuk ke fasilitas kesehatan. Oleh karena itu dirancang sistem monitoring kondisi kehamilan untuk deteksi dini preeklampsia menggunakan metoda Certainty Factor berbasis Android. Sistem ini terdiri dari alat ukur tekanan darah dan sistem pakar. Alat ukur tensimeter menggunakan sensor tekanan MPX5500, filter high pass butteworth dan mikrokontroller Arduino terhubung ke smartphone android melalui Bluetooth. Sistem pakar akan mendiagnosa ibu hamil beresiko preklampsia atau hipertensi dalam kehamilan tanpa resiko preklamsia. Alat ukur tekanan darah yang dirancang untuk mendukung sistem, bekerja dengan rata-rata selisih terhadap pengukuran tensimeter aneroid sebesar 7,05 mmHg dengan galat 6,24 % pada tekanan sistolik dan 10,15 mmHg dengan galat 13,13 % pada tekanan diastolik. Hasil diagnosa sistem pakar memiliki akurasi sebesar 91,45 %. Sehingga dapat dikatakan bahwa sistem yang dirancang telah dapat digunakan.Kata Kunci : Preklamsia, tensimeter, sistem pakar certainty factor

The Role of Estrogen in the Development of Breast Cancer Massardi, Nikki Aldi
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.280

Breast cancer is a hormone-dependent disease that relies on the mitogenic effect ofestrogen to increase tumorigenesis and tumor growth. Clinically significant levels ofestrogen-Î± receptor (ERÎ±) expression are seen in 80% of human breast cancers,whereas progesterone receptor is expressed in 55% of human breast cancers. Thesedata are one of the bases for the development of endocrine therapy. Endocrinetherapy is therapy that targets the pathway and synthesis of estrogen, by blocking itvia receptors, reducing circulating levels of estrogen, or suppressing estrogensynthesis in the tissues of women diagnosed with breast cancer.

Sistem Peringatan Awal Resiko Preklamsia pada kehamilan menggunakan metoda Certainty Factor dan Android Fitrilina Fitrilina; M. Albbi; Indra Agustian; Afriyastuti Herawati; Nikki Aldi Massardi
JURNAL NASIONAL TEKNIK ELEKTRO Vol 10, No 1: March 2021
Publisher : Jurusan Teknik Elektro Universitas Andalas

The mortality rate for pregnant women due to preeclampsia is still quite high in Indonesia in general and Bengkulu province in particular. There is no effective method to prevent preeclampsia, but early detection can help for proper treatment. Monitoring the condition of pregnancy is very important but the COVID-19 pandemic has prevented pregnant women to go to health facilities. Therefore, a pregnancy condition monitoring system was designed for early detection of preeclampsia using the android-based Certainty Factor method. The system designed consists of a blood pressure measuring device and an expert system. The device uses an MPX5500 pressure sensor, highpass Butterworth filter and an Arduino connected to an android smartphone via Bluetooth. The expert system will diagnose that pregnant women are at risk of preeclampsia or hypertension in pregnancy without the risk of preeclampsia. The blood pressure measuring device works with an average difference to the aneroid sphygmomanometer of 7.05 mmHg with an error of 6.24% at systolic pressure and 10.15 mmHg with an error of 13.13% at diastolic pressure. The result of expert system diagnosis has an accuracy of 91.45%. So it can be said that the designed system can be used Keywords : Preeclampsia, Blood Pressure Device, Certainty Factor MethodAbstrakAngka kematian Ibu hamil (AKI) karena preeklampsia masih cukup tinggi di Indonesia umumnya dan provinsi Bengkulu khususnya. Belum ada metoda yang efektif untuk mencegah terjadinya preeklampsia, tetapi deteksi dini dapat menolong untuk penanganan dan pengobatan yang cepat dan tepat. Monitoring kondisi kehamilan sangat penting, tetapi pandemi COVID-19 menyebabkan ibu hamil tidak dianjurkan untuk ke fasilitas kesehatan. Oleh karena itu dirancang sistem monitoring kondisi kehamilan untuk deteksi dini preeklampsia menggunakan metoda Certainty Factor berbasis Android. Sistem ini terdiri dari alat ukur tekanan darah dan sistem pakar. Alat ukur tensimeter menggunakan sensor tekanan MPX5500, filter high pass butteworth dan mikrokontroller Arduino terhubung ke smartphone android melalui Bluetooth. Sistem pakar akan mendiagnosa ibu hamil beresiko preklampsia atau hipertensi dalam kehamilan tanpa resiko preklamsia. Alat ukur tekanan darah yang dirancang untuk mendukung sistem, bekerja dengan rata-rata selisih terhadap pengukuran tensimeter aneroid sebesar 7,05 mmHg dengan galat 6,24 % pada tekanan sistolik dan 10,15 mmHg dengan galat 13,13 % pada tekanan diastolik. Hasil diagnosa sistem pakar memiliki akurasi sebesar 91,45 %. Sehingga dapat dikatakan bahwa sistem yang dirancang telah dapat digunakan.Kata Kunci : Preklamsia, tensimeter, sistem pakar certainty factor

CLINICAL MANIFESTATION OF COVID-19 CO-INFECTION CASE IN BENGKULU CITY Debie Rizqoh; Enny Nugrahaeni; Jusup Endang; Mulya Sundari; Dessy Triana; Mardhatillah Sariyanti; Nikki Aldi Massardi
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.32666

Background: The COVID-19 pandemic is still ongoing, and no one could predict when it would end. In some cases of COVID-19, patients experienced infection by SARS-Cov-2 and other microorganisms, including viruses, bacteria, and fungi.Objective: This study aims to determine Co-infection on clinical symptoms and mortality of COVID-19 patients in Bengkulu City, Indonesia.Methods: We reviewed and analyzed data on patients with confirmed COVID-19 who were co-infected, including basic information, clinical manifestations, radiological and laboratory examinations, to the final status.Results: A total of 105 patients with confirmed COVID-19 participated in this study with various clinical manifestation: mild case (12%), moderate case/ mild pneumonia (52%), severe pneumonia (20%) and critical case (16%). Of the 105 patients, six patients were co-infected with human immunodeficiency virus (HIV) (1 case), Mycobacterium tuberculosis (2 cases), Salmonella thypii (2 cases), bacterial pneumonia, and viral pneumonia (1 case). As many as three of the six patients experienced inferior clinical manifestations and died.Conclusion: The co-infection of other microorganisms in COVID-19 can affect the severity and mortality in COVID-19 patients.

Trends in IgG Antibody Levels in Covid-19 Patients in Different Clinical Manifestations in Bengkulu City: Cohort Study Debie Rizqoh; Enny Nugrahaeni; Mulya Sundari; Dessy Triana; Mardhatillah Sariyanti; Nikki Aldi Massardi
AgriHealth: Journal of Agri-food, Nutrition and Public Health Vol 3, No 2 (2022): October
Publisher : Research and Development Center for Food, Nutrition and Public Health (P4GKM) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agrihealth.v3i2.61315

More than two years have lasted since the coronavirus disease 2019 (Covid-19) pandemic. The case of Covid-19 in Indonesia has spread to all provinces and areas such as Bengkulu City. This study aims to determine the profile of clinical manifestations and antibody dynamics in Covid-19 patients in Bengkulu City. This study used a cohort design on Covid-19 patients at two Bengkulu City referral hospitals, M. Yunus Hospital and Harapan dan Doa Hospital. Data on clinical manifestations were obtained from the medical records of Covid-19 patients. Meanwhile, to determine the level of IgM and IgG antibodies, patient serum samples were taken directly from respondents from the beginning of hospital admission three times on the 1st, 2nd and 3rd weeks. Then the samples were examined by immunofluorescent assay method. The results of this study indicate that, in general, there are no significant differences in anti-SARS-CoV-2 IgG levels in Covid-19 patients in the 1st, 2nd and 3rd weeks of Covid-19 in Bengkulu City. The Spearman correlation test also showed no correlation between IgG levels and the clinical manifestations of Covid-19. Although not statistically significant, there was a trend towards differences in antibody levels in patients with mild, moderate and severe clinical manifestations. The results of this study indicate that there are variations in antibody dynamics in Covid-19 patients in Bengkulu City.

Interrelation between Handwashing and the Severity of COVID-19: A non-representative cross-sectional study Nabila Putri Firdalina; Riry Ambarsarie; Utari Hartati Suryani; Dessy Triana; Nikki Aldi Massardi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 2 (2022): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i2.14248

Corona Virus Disease 2019 (COVID-19) pandemic remains a global issue, including in Indonesia. Handwashing using soap can reduce the viral load of the SARS-CoV-2 virus and prevent coinfection, which can worsen symptoms in COVID-19 patients. This study aims to determine the relationship between knowledge, attitudes, and handwashing behavior to the severity of COVID-19. Research using a cross-sectional and retrospective approach was conducted from July to December 2020 in Bengkulu Province. About 107 respondents had been confirmed positive for Covid-19 with the rt-PCR test, aged 17-60 years, and were willing to participate. Knowledge, attitudes, and behaviors were assessed using validated questionnaires and data on the severity of disease obtained from epidemiological forms. The collected data were then analyzed using chi-square statistical tests. 107 respondents had already filled in the questionnaires. The Chi-square test showed no significant association between knowledge (p 0.081), attitude (p 0.216), and behavior (p 0.136) of handwashing to the severity of COVID-19. A good level of knowledge, attitudes and behaviors about handwashing using soap did not adequately affect the severity of covid-19 patients. The good level of knowledge, attitude, and practice of HWUS were not significant enough to affect the severity of the COVID-19 disease.

The Role of Estrogen in the Development of Breast Cancer Nikki Aldi Massardi
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.280

Breast cancer is a hormone-dependent disease that relies on the mitogenic effect of estrogen to increase tumorigenesis and tumor growth. Clinically significant levels of estrogen-α receptor (ERα) expression are seen in 80% of human breast cancers, whereas progesterone receptor is expressed in 55% of human breast cancers. These data are one of the bases for the development of endocrine therapy. Endocrine therapy is therapy that targets the pathway and synthesis of estrogen, by blocking it via receptors, reducing circulating levels of estrogen, or suppressing estrogen synthesis in the tissues of women diagnosed with breast cancer.

Probiotic Lactobacillus acidophilus FNCC 0051 Improves Pancreatic Histopathology in Streptozotocin-induced Type-1 Diabetes Mellitus Rats Mardhatillah Sariyanti; Tiara Ayoe Andita; Noor Diah Erlinawati; Elvira Yunita; Ahmad Azmi Nasution; Kartika Sari; Nikki Aldi Massardi; Sylvia Rianissa Putri
The Indonesian Biomedical Journal Vol 14, No 4 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i4.2047

BACKGROUND: Intestinal microbial dysbiosis and its metabolites can affect the immune activity of intestinal mucosal cells, causing insulitis and pancreatic β-cell death. Probiotic Lactobacillus acidophilus plays an important role in reducing inflammatory cytokines, hence improves oxidative stress that affects pancreatic β-cell apoptosis. Current study examined the feature of pancreatic histopathology affected by the administration of probiotic L. acidophilus in rats with type-1 diabetes mellitus (DM) induced by streptozotocin (STZ).METHODS: Twelve rats were induced by STZ at double dose of 50 mg/kgBB before administered with probiotic L. acidophilus at a dose of 1.5x10 8 or 1.5x10 9 CFU/mL/day, while other 4 rats were used as control. After 21 days of the L. acidophilus treatment, the average of fasting blood glucose (FBG) levels of rats were measured, then the pancreatic histopathology was assessed to evaluate the degree of insulitis in islet of Langerhans.RESULTS: The induction of STZ had been succeeded to increase blood glucose levels, which indicate DM condition. The highest FBG level after 21 days of treatment was found in DM group with glucose level of 512±81.51 mg/dL. The administration of probiotic L. acidophilus during 21 days treatment at both dose 1.5x10 8 and 1.5x10 9 CFU/mL/day significantly improved pancreatic histopathology (p=0.04 and p=0.034, respectively), with significant decrease on insulitis scores compared to DM group.CONCLUSION: The administration of L. acidophilus at both dose of 1.5x10 8 and 1.5x10 9 CFU/mL/day for 21 days can improve pancreatic histopathology of type-1 DM rats induced by STZ, therefore probiotic L. acidophilus may be potential as supplementation treatment for type-1 DM.KEYWORDS: Lactobacillus acidophilus, pancreatic histopathology, streptozotocin, type-1 diabetes mellitus

Health Education About Clean and Healthy Lifestyle Behavior (PHBS) in the Transition Period of the Covid-19 Pandemic for Students Debie Rizqoh; Ellen Maidia Djatmiko; Nikki Aldi Massardi; Alvi Jalilul Hakim; Novita Arifani; Azella Chika Fauzia
DIKDIMAS : Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2023): DIKDIMAS : JURNAL PENGABDIAN KEPADA MASYARAKAT VOL 2 NO 1 APRIL 2023
Publisher : CV Media Inti Teknologi

After the COVID-19 pandemic is ongoing up to 3 years, finally Indonesia started experience transition from pandemic going to endemic, following decreasing of case positive for COVID-19. During the transition, a number of rule start relaxed, however government recommend public for still carry out health protocol. Besides, in field education, all school carry out 100 % offline learning. The students have to stay alert from COVID-19 infection or another infection. So that, clean and healthy lifestyle (PHBS) is necessary carried out at school. There are several indicators of PHBS in schools that are necessary known by students. This health education aims to give education to 97 students in schools especially at SMK Negeri 2 Bengkulu City about importance implementing PHBS in the transition period of COVID-19 pandemic. This activity took place on Thursday , 22 September 2022. The method used form give education and discussion regarding PHBS in schools. We evaluated student’s understanding by pre-test and post-test about PHBS. Participant generally already have own knowledge regarding PHBS and more understand PHBS after participated in this activity.

The Relationship Between Age and Clinical Manifestations and COVID-19 Severity in Bengkulu in 2020 Utari Hartati Suryani; Dessy Triana; Riry Ambarsarie; Zayadi Zainuddin; Nikki Aldi Massardi; Begumratu Voca; Dia Triyani Putri
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 12 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i12.643

The infectious disease COVID-19 caused by the SARS-CoV-2 virus can infect all age groups. The symptoms that arise can vary from no symptoms to severe and critical symptoms. Differences in clinical symptoms can occur due to differences in the distribution, maturation and function of the SARS-CoV-2 virus receptors. These clinical symptoms will determine the severity of COVID-19. This study aims to analyze the relationship between age and clinical symptoms and the severity of COVID-19 in Bengkulu Province in 2020. This study used an observational analytic study with a cross-sectional design. Samples were taken using a consecutive sampling technique and a total of 109 subjects were obtained who were COVID-19 patients in Bengkulu Province from March to December 2020. Assessment of clinical symptoms used COVID-19 epidemiological investigations. The degree of severity is determined based on the Guidelines for the Prevention and Control of COVID-19 by the Ministry of Health of the Republic of Indonesia. The relationship between the two variables was analyzed using the Spearman Rank test. The results of this study indicate that there is a significant relationship between the age factor of COVID-19 patients in determining the severity of COVID-19 (p=0.000; p <0.05).

Co-Authors Afriyastuti Herawati Agustian, Indra Ahmad Azmi Nasution Akbar, Novrian Albbi, M. Alvi Jalilul Hakim Azella Chika Fauzia Begumratu VOCA Begumratu Voca Beti Ernawati Dewi Debie Rizqoh Dessy Triana Dessy Triana Dessy Triana Dessy Triana Destilyana, Rizqita Dewi Wulandari Dewi Wulandari Dia Triyani Putri Dia Triyani Putri Eduardus Gilang Putra Ellen Maidia Djatmiko Elvira Yunita Enny Nugrahaeni Enny Nugrahaeni Fitrilina Fitrilina Fitrilina, Fitrilina Gunasari, Lala Foresta Valentine Herawati, Afriyastuti Indra Agustian Jayawarsa, A.A. Ketut Jusup Endang Kartika Sari Liya Agustin Umar M. Albbi Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mulya Sundari Mulya Sundari Nabila Putri Firdalina Naurah Shafa Putri Cahyangi Noor Diah Erlinawati Novita Arifani Putra, Eduardus Gilang Putri Syifa Nabilah Riry Ambarsari Riry Ambarsarie Riry Ambarsarie Soemanadi Soemanadi Sylvia Rianissa Putri Tiara Ayoe Andita Utari Hartati Suryani Zayadi Zainuddin

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