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All Journal E-Jurnal Medika Udayana Molecular and Cellular Biomedical Sciences (MCBS)
I Made Arya Winangun
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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MANAGEMENT OF INTERNAL HEMORRHOID WITH RUBBER BAND LIGATION PROCEDURE I Made Arya Winangun; Putu Anda Tusta Adiputra; Sri Maliawan; Ketut Siki Kawiyana
E-Jurnal Medika Udayana vol 2 no 10 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.641 KB)

Abstract

Hemorrhoid is regarded as the cases most seen in population. The prevalence of this cases about 4,4% with the incidence 12 of 1.000 patient. The current management of hemorrhoid is lifestyle modification, conservative management such as farmacology, minimally invasive treatment and more aggressive therapy using surgical procedure. Rubber band ligation was one of the minimally invasive procedures. This procedure was easy, inexpensive, and can be done outpatient using simple tools without complicated procedure like hemorrhoidectomy. Some studies explained rubber band ligation effectively done in internal hemorrhoid grade II and grade III even this procedure still had minimal complication such as bleeding and unpleasentness
Decreased Follistatin Levels as a Risk of Acute Sarcopenia Marker in Elderly Aryana, I Gusti Putu Suka; Winangun, I Made Arya
Molecular and Cellular Biomedical Sciences Vol 7, No 3 (2023)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v7i3.359

Abstract

Background: Acute sarcopenia is an acute muscle loss that has been associated to the frailty and vulnerability of the elderly. Follistatin has been known as a significant marker for sarcopenia, however, studies of follistatin in humans have shown varying results and there have been no studies to date regarding the relationship between follistatin and acute sarcopenia. The aim of this study was to determine changes in follistatin levels as a risk of acute sarcopenia in elderly.Materials and methods: This study was a prospective observational study involving hospitalized elderly. The follistatin level was examined with enzyme-linked immunosorbent assay (ELISA). Meanwhile the determination of acute sarcopenia was done through the measurement of changes in hand grip strength and calf circumference parameters. The data obtained was descriptively analyzed, followed by bivariate and multivariate analysis. A p<0.05 was considered significant.Results: There were 66 subjects in this study. A total of 10 subjects (15.2%) had acute sarcopenia on the 7th day of hospitalization. The cut-off point of decreased follistatin levels was 4.870 with a sensitivity of 82.1% and a specificity of 60%. There was an association between decreased follistatin levels and acute sarcopenia (p=0.01; RR: 6.90; 95% CI: 1.638-29.069). Multivariate analysis results showed that decreased follistatin levels was a significant factor that might influence the occurrence of acute sarcopenia.Conclusion: Since this study showed that decreased follistatin levels might be a risk of acute sarcopenia in the elderly, thus it could be used as a marker of acute sarcopenia, which should be further investigated.Keywords: decreased follistatin levels, acute sarcopenia, elderly
Co-Authors Aryana, I Gusti Putu Suka Ketut Siki Kawiyana Putu Anda Tusta Adiputra Sri Maliawan