Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal Jurnal Kefarmasian Indonesia
M. Wien Winarno
Pusat Biomedis dan Teknologi Dasar Kesehatan Jl. Percetakan Negara No,23 Jakarta 10560, Indonesia
Chemistry Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Efek Daun Dewa (Gynura pseudo-china Aug D.C.) terhadap Peningkatan Trombosit Tikus Putih yang Diinduksi Hidroksi Urea Winarno, M. Wien; Suciati, Yesi; Sediarso, H.
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2842

Abstract

Daun dewa (Gynura pseudo-china Aug. DC), empirically used as anti-inflammation, anti-diare, anti-tumor, and anti-fungus Additionally, it also used to prevent blood vessel contriction, and stimulate the immune system. The leaf flom Daun Dewa empirically used to dengue fever treatment. In this study, 25 white rats Wistar strain were used which is divided into 5 groups J I) control group, 2) study group, which is divedid into 3 doses (100 mg, 200 mg, 400 mg/200g body weight) and 3) the normal control group (without induced). Hydroxy urea dose 27 mg/200 g body weight 2 times a day for induced. The treatment given 8 days dividing and every 2 days once done taking 0,5 ml of blood via the tail vein. Result showed ethanol leaf extract of Daun dewa dose 100 mg, 200 mg, and 400 mg/ 200 g body weight increase thrombocyte. Incease thrombocyte going on forth day afier the test dose, and the sixth day amount thrombocyte have reached normal.
Efek Pemberian Air Embun terhadap Gambaran Hematologi dan Biokimia Darah Widowati, Lucie; Astuti, Yun; Winarno, M. Wien
Jurnal Kefarmasian Indonesia VOLUME 2 NOMOR 2, AGUSTUS 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Circulation disorder of blood at a person is related to metabolic process, and it can not be as the normal equilibirum, and later can affect to appearance of disseases. Dew water, can be produced from destilation process (Systemized Dew Process), filtered process and disinfection with ozoniation. Dew water is stated can be used for disorder of blood circulation treatment. For the examination effect of dew water for blood circulation disorder, dew water was tested for blood description and biochemistry blood description at the animal model with cholesterol diet.It was the experimental pharmacology method, with the blood description as hamoglobline, erythrocyte, leucocyte, thrombocyte, hematochrite value; biochemistry description as total cholesterol, LDL cholesterol, HDL cholesterol, trigliserid; freeze time of blood; the arteri thickness ; body weight and the volume of intake water. Base on the normally of dosage at human, dew water intake for animal model were all day long admintration and of all of research time, every day for 2 month. The result of research has shown decrease of the body weight; increase need for intake water ; repairing haematology and biochemistry of blood, escpecially decrease of total cholesterol and LDL cholesterol; diluting blood; decreasing ateroschlerosis disorder at arteri vessel
Efek Ekstrak Campuran Kulit Batang Pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada Mencit Swiss Webster yang Diinfeksi Plasmodium berghei Intan, Putri Reno; Winarno, M. Wien; Prihatini, Nita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2949

Abstract

Pulai and meniran is one of the medicinal plants that have been studied as a possible antimalarial drugs. This study aims to evaluate the antimalarial activity of a mixture of pulai bark and meniran extracts as antimalarial drugs. Acute toxicity tests was performed using male and female Wistar rats each 25 animals with four doses of treatment. Antimalarial test using 72 mice were divided into six dose groups: group CMC, DHP, dose mixture of 1330; 443.34; 147.78 mg/kg bw and doses of pulai groups 1330 mg /kg bw. All the mice were infected with Plasmodium berghei (D0) and given the extracts orally for 14 days. Giemsa blood stainning taken on days D1-D7 and D14 were analyzed for percentage of parasitaemia, lymphocytes, monocytes and granulocytes. Results of acute toxicity test (LD50) values obtained from extract mixture was more than 14285 mg/kg bw, are classified as non-toxic materials. The most effective dose of the test antimalarial obtained from the percentage of parasites reducing and leukocytes differential, was 147.78 mg/kg. A mixture of pulai bark and meniran extract can be considered to be used as an alternative drug in the treatment of malaria. Further research is needed to isolate and characterized the active ingredients which have the effect of antimalarial to be recommended as an antimalarial drug in the future.
Pengaruh Pemberian Kombinasi Ekstrak Rumput Mutiara (Hedyotis corymbosa Lamk) dan Meniran (Phyllanthus Niruri L.) terhadap Jumlah AgNOR Jaringan Adenokarsinoma Mammae Mencit C3H Intan, Putri Reno; Winarno, M. Wien
Jurnal Kefarmasian Indonesia VOLUME 4. NOMOR 1 FEBRUARI 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cancer is one of the non-communicable diseases that has become a health problem in the world, including in Indonesia. Data World Health Organization (WHO) data in 2010 showed that cancer is the second leading cause of death after cardiovascular disease. Mean while, result at Basic Health Research Riset Kesehatan Dasar (Riskesdas) 2007 showed that cancer ranks sixth in the leading cause of death in Indonesia. Number of cancer patients in Indonesia continues to increase and is expected to be the main cause of the increasing economic burden, for the patient, family, and also country. Types of cancer in Indonesia is dominated by breast cancer (30%) cervical cancer (24%). This study aims to determine the effect of a combination of rumput mutiara (Hedyotis corymbosa Lamk) and meniran (Phyllanthus niruri L) against mammary adenocarcinoma in strain C3H mice. This study is an experimental study. The study sample consisted of 20 strains of C3H mice that were divided into 4 groups: control group (K) and three dose groups ( P1 - P3 ), namely : dose 750 ; 1500; 2250 mg/kg BW. Extract of the test material were given after the tumor is palpable, It was given to the mice for 19 days, once a day orally using a stomach sonde. The results of this study indicate that based on the average number of AgNOR mammary adenocarcinoma, the extract at a dose of 2250 mg/kg BW can reduce the proliferation of mammary tumor cells.
Co-Authors H. Sediarso Lucie Widowati Prihatini, Nita Putri Reno Intan Yesi Suciati Yun astuti