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Putri Anggraini Budianto
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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ANALISIS IN SILICO PENCEGAHAN PENUAAN KULIT MELALUI PENGHAMBATAN CELLULAR SENESCENCE TERTARGET INHIBISI CD36 OLEH SENYAWA AKTIF CINNAMOMUM ZEYLANICUM Putri Anggraini Budianto; Novia Permata Hapsari; Dhiya Ulhaq Salsabila
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.85

Abstract

Introduction: Increased ROS (reactive oxygen species) and SASP (senescence-associated secretory phenotype) lead to skin aging via cellular senescence. CD36 (Cluster Difference 36) is found overexpressed in senescent cells and accepts various activators that generate ROS and SASP. Cinnamon (Cinnamomum zeylanicum) has been known to exert several pharmacological effects like antioxidant and anti-senescence. However, its anti-senescence effect on CD36 has not been reported yet. This study aims to prove that cinnamon’s compounds are effective to inhibit CD36 in order to stop skin aging caused by senescence. Methods: Literature studies and in silico approaches such as database searching, molecular docking, and KNIME open analytic platform were used in this study. Result: Cinnamaldehyde is proven as a better competitive CD36 inhibitor (DICE Score: 0,886; Tanimoto Score: 0,939) with better affinity than native ligand and previously studied inhibitors (RMSD: 0,74 Å; S: -7,43 kcal/mol). Bioinformatics investigations also showed that major compounds of cinnamon target CD36 regulator, oxidoreductases, and SASP-producing receptors that co-expressed with CD36. Conclusion: Active components of cinnamon are potential to be an anti skin aging by inhibiting CD36, regulating CD36, and eradicating senescent factors.
INHIBISI DNMT3B UNTUK MENGHAMBAT PERKEMBANGAN SEL KANKER KULIT DENGAN SENYAWA MINYAK ATSIRI KAYU MANIS MELALUI STUDI IN SILICO DAN PROTEOMIK Khusnul Agustina; Putri Anggraini Budianto; Christopher Filando Santoso; Rumiyati Rumiyati
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.92

Abstract

Introduction: Cinnamon (Cinnamomum cassia) is often used as a medicinal plant because of its antioxidant properties. UV overexposure leads to many harmful impacts, one of them being the increasement rate of skin cancer risk. UV rays increase DNMT3B expression and ROS level. However, anti-skin cancer drugs that target DNMT3B have not been explored yet, and this study aims to explore cinnamon essential oil's potency in targeting DNMT3B to stop UV-induced skin cancer development. Methods: The research was carried out through an in silico and proteomic approach. Research materials were obtained from various databases including CMAUP, ChEMBL, PubChem, Google Scholar, PubMed, and RCSB. The materials that have been obtained are processed using KNIME and MOE V.2010 software Result: As a result, KNIME analysis showed many similarities between four of cinnamon's active compounds and DNMT3B inhibitors (azacytidine and decitabine). Three of the essential oil compounds; Cinnamaldehyde, cis-2-methoxy cinnamic acid, and coumarin are predicted to inhibit DNMT3B. Moreover, using the molecular docking approach, cis-2-methoxy cinnamic acid has more stable bonds compared to its native ligand (glycerol). Conclusion: In conclusion, the active compounds in cinnamon essential oil were potential to inhibit DNMT3B and prevent skin cancer development with cis-2-methoxy cinnamic acid as the most potent inhibitory compound. Keywords: Cinnamon, skin cancer, DNMT3B, cis-2-methoxycinnamic acid.
Co-Authors Christopher Filando Santoso Dhiya Ulhaq Salsabila Khusnul Agustina Novia Permata Hapsari Rumiyati Rumiyati