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All Journal Indonesian Journal of Chemistry Jurnal Biosense JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
Nurlaili Nurlaili
Akademi Kesehatan Kartini Batam
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Microwave Assisted Synthesis and Evaluation of Toxicity and Antioxidant Activity of Pyrazoline Derivatives Jasril Jasril; Hilwan Yuda Teruna; Aisyah Aisyah; Nurlaili Nurlaili; Rudi Hendra
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.72 KB) | DOI: 10.22146/ijc.34285

Abstract

Four pyrazoline analogues, 3-(4-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (3), 3-(4-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (4), 3-(2-methoxyphenyl)-5-naphthalene-1-yl-1-phenyl-4,5-dihydro-pyrazole (5) and 3-(2-methoxyphenyl)-5-naphthalene-1-yl-4,5-dihydro-1H-pyrazole (6) were synthesized via intermolecular cyclization between substituted chalcones and hydrazine derivatives. The compounds were synthesized in two steps. In the first step, the chalcones were synthesized by Claisen-Schmidt reaction. In the second step, they were cyclized with some hydrazine derivatives to form pyrazolines by using glacial acetic acid as a catalyst and assisted by microwave irradiation. The toxicity analysis showed that compound 1 and 2 were toxic with LC50 values of 11.47 and 0.97 μg/mL, respectively. Furthermore, only compound 6 showed high antioxidant activity by using DPPH with an IC50 value of 4.47 μg/mL.
PENAMBATAN MOLEKUL SENYAWA VOLATIL EKSTRAK DIKLOROMETANA SAMBILOTO TERHADAP JALUR PENSINYAL EPIDERMAL GROWTH FACTOR RECEPTOR: Penambatan Molekul Senyawa Volatil Ekstrak Diklorometana Sambiloto Terhadap Onkoprotein Human Epidermal Growth Factor Receptor Muhammad Faisal; Nurlaili Nurlaili; Potchanapond Graidist; Varomyalin Tipmanee
JURNAL BIOSENSE Vol 5 No 01 (2022): Edisi Juni 2022
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.581 KB) | DOI: 10.36526/biosense.v5i01.1948

Abstract

EGFR oncoprotein has been commonly studied in combating cell cancer development. However, until this moment the EGFR inhibitors were reported to cause other health issues. Plant extracts are trusted as the potential inhibitor of EGFR expression level without affect our health. We previously observed seventeen volatile compounds in the dichloromethane extract of Andrographis paniculata. Our objective was to analyze the interaction of volatile compounds from the dichloromethane extract of Andrographis paniculata on human EGFR pathway. In silico technique with ligand-receptor molecular docking was used in this study. The structure of volatile compounds was set as the ligands. EGFR, PIK3CA, KRAS-GTP, BRAF V600E, and AKT protein structures were assigned as the receptors. PyRx and Biovia Discovery Studio were used in this docking study. Drug-likeness and lead-likeness properties were appraised by SwissADME and Pre-ADME/Tox web tools. Beta-amyrin and stigmasterol showed the highest binding affinity to EGFR oncoproteins. PIK3CA, AKT, and KRAS-GTP, BRAF V600E was bound to beta-amyrin and stigmasterol, respectively. Those compounds structurally showed drug-likeness and non-mutagenic. Briefly, beta-amyrin and stigmasterol will be potentially used as the inhibitors of selected oncoproteins. In vitro technique and animal model are suggested to be performed to validate the mutagenic mechanisms of beta-amyrin and stigmasterol
IDENTIFIKASI JENIS TELUR NEMATODA USUS GOLONGAN Soil Transmitted Helminth (STH) DI KAWASAN PASIR PANTAI KECAMATAN SEKUPANG KOTA BATAM Deasy Ovi Harsachatri; Raden Muhamad Taupik; Nurlaili Nurlaili; Mifthahul Jannah
JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Vol. 2 No. 2 (2024): Mei
Publisher : CV. ALIM'SPUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/jikas.v2i2.769

Abstract

. Soil Transmitted Helminth (STH) is a group of intestinal nematode worms that require soil for the maturation process so that there is a change from a non-infective stage to an infective stage. This study aims to find out whether in the coastal sand area of Sekupang District, Batam City, there are intestinal nematode eggs of the Soil Transmitted Helminth (STH) group. The method used in this study is a survey method by taking sand samples from 3 different beaches, namely Tanjung Pinggir beach, Dangas beach, and Marina beach, then the sample is examined, namely by soaking the sample with 15 ml of saturated NaCl for 30 minutes stirring until evenly distributed with a stirring rod then transferred the soaking water in a test tube. Deck glass is placed on top at the mouth of the tube for 60 minutes. Then the sample was observed under a microscope with a magnification of 10 to 40 then analyzed descriptively by making a picture systematically. The results showed that there were no intestinal nematode worm eggs of the STH group in the beach sand sample so that it could be concluded that the tannjung beach sand area of Sekupang District, Batam City was free from contamination of intestinal nematode worm eggs of the soil transmitted helmith (STH) group.
Co-Authors Aisyah Aisyah Deasy Ovi Harsachatri Hilwan Yuda Teruna Jasril Jasril Mifthahul Jannah Muhammad Faisal Potchanapond Graidist Raden Muhamad Taupik Rudi Hendra Varomyalin Tipmanee