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Ni Putu Wirantari
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Health Professions Medicine & Pharmacology

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NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT Ni Putu Wirantari; I Made Jawi; Bagus Komang Satriyasa
E-Jurnal Medika Udayana vol 2 no 7 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hypertension is a silent killer because it causes complications in vital organs unwitting patients. Beta blockers are generally a choice of safe and effective drugs for initial treatment of hypertension. However, the current hypertension treatment guidelines said beta blockers were not suitable use as first-line therapy because of complications caused. On the use of atenolol found an increased incidence of cardiovascular death of 24%, 14% and cardiac complications 23% cerebrovascular complications. Nebivolol is a third-generation beta-blocker that is highly selective for ?1-adrenergic receptors and has the ability as a direct vasodilator was able to stimulate the activity of endothelial L-arginin/nitric oxide synthase, is expected nebivolol can reduce blood pressure so can achieve blood pressure that expected.
Co-Authors Bagus Komang Satriyasa I Made Jawi