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All Journal Jurnal Matematika & Sains Jurnal Biologi Tropis Jurnal Mandala Pharmacon Indonesia Science Midwifery Jurnal Kesehatan Tambusai Indonesian Journal of Pharmaceutical Education Jurnal Farmasi Tinctura Humantech : Jurnal Ilmiah Multidisiplin Indonesia Journal of Nutrition Science Journal of Pharmaceutical and Sciences.
Donn Richard Ricky
Universitas Advent Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Nanocurcumin Particle Sizes on the Inhibitory Potential on Staphylococcus aureus and Escherichia coli Tnunay, Fiona Rosslyn; Ricky, Donn Richard; Tobing, Joshua H. L.
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10598

Abstract

Increasing antibiotic resistance against major pathogens like Staphylococcus aureus and Escherichia coli are necessitates as alternative antimicrobials. Curcumin, known for its antibacterial properties, suffers from low bioavailability; thus, developing it into nanocurcumin using the stabilizer PVP is aims in enhancing its efficacy. This study was conducted to investigate the effect of nanocurcumin particle sizes (controlled by three PVP K30 concentrations: 1.5, 3.0, and 4.5 g/mL) on its inhibitory potential on Staphylococcus aureus and Escherichia coli. The research is a true laboratory experimental design, synthesizing nanocurcumin via a Rotor Stator Homogenizer and assessing antibacterial activity using the disc diffusion method on Mueller Hinton Agar (MHA), with inhibition zone diameters are analyze using One-Way ANOVA. All tested samples exhibit weak inhibitory potential. The ANOVA revealed no significant effect against Staphylococcus aureus (p = 0.377), but shows a significant effect against Escherichia coli (p = 0.042). These finding shows that particle size variations of nanocurcumin influence against Gram-negative bacteria, with the smallest average particle size (20.6 nm) obtained at 1.5 g/mL PVP K30. In conclusion, nanocurcumin size variations significantly affect the inhibition against Escherichia coli but not against Staphylococcus aureus, a differential effect attributed to the distinct cell wall structures of the two bacteria types. Future studies are recommended to explore optimization methods to improve nanocurcumin's efficacy, especially against Staphylococcus aureus.
The Effect of Nanocurcumin Size Inhibitory Effect on Klebsiella pneumoniae and Staphylococcus aureus Bacteria Suak, Raffael Griffin Frarie; Ricky, Donn Richard; Tobing, Joshua Hamonangan Lumban
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10776

Abstract

Bacterial infections such by Staphylococcus aureus and Klebsiella pneumoniae remain a major health challenge due to the increasing problem of antibiotic resistance. Curcumin has shown antibacterial potential; however, its poor solubility and low bioavailability limit its effectiveness. This study aimed to analyze the effect of varying PVP K30 concentrations on the particle size of nanocurcumin and its inhibitory activity against both bacteria. A true experimental design with a posttest-only control group was employed using three concentrations of PVP K30: 1.5 g/mL, 3.0 g/mL, and 4.5 g/mL. Particle size was measured using a Particle Size Analyzer (PSA), while antibacterial activity was evaluated through the disk diffusion method on Mueller-Hinton Agar (MHA). The results showed that increasing PVP K30 concentration reduced particle size, with mean diameters of 132.2 nm, 295.2 nm, and 20.6 nm, respectively. The inhibition zones by S. aureus ranged from 1.82–3.6 mm (weak), while those by K. pneumoniae ranged from 1,08–8,98 mm (weak to moderate). ANOVA analysis indicated no significant effect on S. aureus (p= 0.099 > α= 0.05), but a significant effect on K. pneumoniae (p= 0.000 < α= 0.05). These findings suggest that nanoparticle size plays an essential role in enhancing the antibacterial activity of nanocurcumin, particularly against Gram-negative bacteria.
Pengaruh Ukuran Nanokurkumin terhadap Daya Hambat pada Propionibacteriun Acnes dan Pseudomonas aeruginosa Pony Siti Afriyanti; Donn Richard Ricky; Joshua H. L. Tobing
Tinctura Vol 7 No 1 (2025): Jurnal Farmasi Tinctura
Publisher : Program Studi S1 Farmasi Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/tinctura.v7i1.8255

Abstract

Senyawa kurkumin yang berasal dari Curcuma longa memiliki aktivitas antibakteri, namun kelarutannya rendah sehingga efektivitasnya terbatas. Teknologi nanopartikel dikembangkan untuk meningkatkan kelarutannya sehingga dapat meningkatkan aktivitas antibakterinya. Penelitian ini bertujuan mengetahui pengaruh ukuran nanokurkumin terhadap daya hambat Propionibacterium acnes dan Pseudomonas aeruginosa. Metode yang digunakan adalah eksperimental laboratorium dengan rancangan posttest only control group. Nanokurkumin disintesis menggunakan variasi konsentrasi polivinilpirolidon (PVP K30) sebesar 1,5, 3,0, dan 4,5 g/mL. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram pada media Mueller-Hinton Agar (MHA), dan diameter zona hambat diukur menggunakan jangka sorong digital. Hasil pengujian menunjukkan bahwa peningkatan konsentrasi PVP K30 menghasilkan ukuran partikel lebih kecil, yaitu 132,2 nm, 295,2 nm, dan 20,6 nm. Ukuran partikel yang lebih kecil memberikan peningkatan daya hambat terhadap kedua bakteri, meskipun hasil analisis ANOVA menunjukkan pengaruh yang tidak signifikan (p = 0,618 > 0,05) terhadap P. acnes dan pengaruh yang signifikan (p = 0,037 < 0,05) terhadap P. aeruginosa. Dengan demikian, ukuran nanopartikel kurkumin berpotensi meningkatkan efektivitas antibakteri terutama terhadap bakteri Gram-negatif.
Stabilitas Ukuran dan Sifat Optik Nanopartikel ZnO yang Dilapisi Polimer Tween 80 Mirthelia Endah Oywari; Donn Richard Ricky; Horasdia Saragih
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1542

Abstract

Background: ZnO nanoparticles are widely used as UV filters in sunscreens due to their broad-spectrum protection and aesthetic transparency. However, agglomeration caused by high surface energy often compromises their efficacy. Coating with non-ionic polymers such as Tween 80 represents a potential stabilization strategy. Objective: This study aims to investigate the effect of varying Tween 80 concentrations on the size stability and optical properties of ZnO nanoparticles. Methods: Tween 80-coated ZnO nanoparticles were synthesized via a solvolysis method assisted by a rotor-stator homogenizer at Tween 80 volume variations of 1, 2, 3, and 4 mL in 50 mL of ethanol. Characterization was performed using a Particle Size Analyzer (PSA) and a UV-Vis spectrophotometer at day 0 and day 60. Results: Increasing Tween 80 concentration significantly reduced the mean diameter of nanoparticles from 17.9 nm to 11.4 nm and narrowed the size distribution (standard deviation decreased from 13.2 nm to 2.8 nm). The zeta potential remained near zero (-0.1 to -0.2 mV) due to the non-ionic nature of Tween 80, yet colloidal stability was maintained through a steric hindrance mechanism. After 60 days of storage, the 4 mL Tween 80 concentration was the most effective in limiting size growth (only 2.6%), compared to 83.7% for the 1 mL concentration. All samples exhibited high transmittance (>87%) in the visible light spectrum while maintaining strong UV absorption. Conclusion: An optimal Tween 80 concentration (4 mL in 50 mL ethanol) is crucial for producing ZnO nanoparticles with long-term size stability and superior optical properties, making them promising for next-generation sunscreen cosmetic formulations.
Enkapsulasi Ganda Nanopartikel ZnO dengan Polimer Tween 80 dan Niacinamide: Karakterisasi Ukuran dan Sifat Optik Horasdia Saragih; Donn Richard Ricky; Josua E. Sagala; Endru S. L. Ginting; William Yustian; Jendri Korisano; Josephine H. Ruskandi; Zahra Mediana; Siska Ari; Ovi S. Humau
Jurnal Mandala Pharmacon Indonesia Vol. 12 No. 1 (2026): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v12i1.1256

Abstract

Permasalahan utama penggunaan ZnO sebagai bahan aktif tabir surya adalah munculnya efek white cast akibat ukuran partikel yang besar. Selain itu, ZnO dapat pula menghasilkan oksidan ketika terpapar radiasi ultraviolet. Penelitian ini bertujuan untuk menyintesis nanopartikel ZnO berukuran sangat kecil (skala nanometer) melalui mekanisme enkapsulasi ganda yang mengintegrasikan Tween 80 dan Niacinamide sebagai lapisan pelindung fungsional. Kebaruan utama studi ini terletak pada peran strategis Niacinamide yang diintegrasikan secara molekuler yang bertujuan untuk menghambat aktivitas fotokatalitik nanopartikel ZnO langsung pada permukaannya. Metode enkapsulasi dilakukan dengan variasi konsentrasi Tween 80 (1, 2, 3, dan 4 mL) dalam pelarut etanol, yang dilanjutkan dengan enkapsulasi menggunakan Niacinamide. Hasil penelitian menunjukkan bahwa peningkatan volume Tween 80 secara efektif menurunkan diameter rata-rata hidrodinamik nanopartikel dan meningkatkan homogenitas ukurannya. Sampel dengan 4 mL Tween 80 menunjukkan performa terbaik dengan diameter rata-rata hidrodinamik terkecil sebesar 11,6 nm dan standar deviasi terendah. Karakteristik optik mengonfirmasi bahwa seluruh sampel memiliki transparansi tinggi (>90%) pada spektrum sinar tampak serta penyerapan energi UV yang tajam pada panjang gelombang <450 nm. Penambahan Niacinamide meningkatkan ketebalan lapisan enkapsulasi dan diameter rata-rata hidrodinamik, namun secara bersamaan memperkecil diameter rata-rata inti nanopartikel ZnO. Temuan ini menyimpulkan bahwa sistem enkapsulasi ganda ZnO-Tween 80-Niacinamide merupakan kandidat unggul untuk formulasi tabir surya transparan berperforma tinggi yang bebas dari efek lapisan putih serta diperkaya dengan manfaat antioksidan dari Niacinamide.
Co-Authors Albinur Limbong, Albinur Charisma Juni Kristianti Claudia, Ellen Cynthia Anggreani Simbolon Dedi, Ronaldus Duma Turu Allo Duma Turu Allo Endru S. L. Ginting Feronyanti Mitranistin Pello Horasdia Saragih Ivonne M. S. Panjaitan Jendri Korisano Josephine H. Ruskandi Joshua H. L. Tobing Josua E. Sagala Masnaria Situmorang Mirthelia Endah Oywari Nababan, Febryanti Ovi S. Humau Pony Siti Afriyanti Sherlin Marthalina putri Natty Simbolon, Gladys Renata Siska Ari Situmeang, Doli Suak, Raffael Griffin Frarie Tnunay, Fiona Rosslyn William Yustian Zahra Mediana