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All Journal International Journal of Nasopharyngeal Carcinoma
Cita Herawati
Department of Ear, Nose, and Throat, Dharmais National Cancer Hospital, Jakarta
Health Professions Medicine & Pharmacology

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CLINICAL SIGNIFICANCE OF PLASMA MIR-21, MIR-141, MIR-29C, AND MIR-BART7 IN PATIENTS WITH LOCALLY ADVANCED NASOPHARYNGEAL CANCER AND THEIR ALTERATIONS AFTER CHEMORADIATION THERAPY Cita Herawati
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 02 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1119.417 KB) | DOI: 10.32734/ijnpc.v1i2.1136

Abstract

Introduction: Plasma microRNAs (miRNAs) are biological markers that have been extensively studied in cancer, including nasopharyngeal cancer (NPC). The clinical significance of miRNA in NPC patients in Indonesia has never been studied. Objective: This study was aimed to know the expression of plasma miRNAs in NPC patients (miR-21, miR-29c, miR-141dan miR-BART7) and their relationship with clinicopathological characteristics and treatment response. Method: This was a cohort, longitudinal study among locally advanced NPC patients (stage IIB-IVB) in Dharmais Cancer Hospital, Jakarta. miRNA expression was assayed using quantitative real-time polymerase chain reaction (qRT-PCR) technique. Four miRNAs were evaluated, i.e., miR-21, miR-29c, miR-141, and EBV-miR-BART7. The results were normalized against a reference gene, miR-16. Result: A total of 52 patients and 10 normal subjects were enrolled in this study; 17 of them completed treatment. Patients’ mean age was 45.1+12.53 (14-68) years. The ratio between men and women was 3:1. MiR-21 and miR-29c could be detected in all subjects; miR-141 was detected in 22 (42.3%) and EBV-miR-BART7 in 26 (50%) subjects. There was no significant difference between miR-21 or miR-29c expression between before and after therapy. However, miR-21 expressions tend to decrease in a patient with complete response (CR) (4.13+3.65 vs. 2.74+3.23; p=0.650) and tend to increase in patients with partial response (PR) (3.00+5.86 vs. 8.77+8.43; p=0.465). There was no difference of miR-29c expression between CR and PR patients. Conclusion: Our study shows that not all miRNA can be detected in the plasma of NPC patients. Levels of miRNA expressions in these locally advanced patients are similar. Expression of miR-21 is potentially used as a biomarker of evaluating treatment response in NPC patients.
Association of Waiting Time for Diagnosis with Quality of Life (QoL) in Nasopharyngeal Carcinoma: A Survey in Dharmais Cancer Hospital Fifi Dwijayanti; Nuryanti Samosir; Cita Herawati
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4768

Abstract

Introduction: Cancer patients experience many symptoms. The symptoms have a major impact on Quality of Life (QoL) among patients with nasopharyngeal carcinoma. Diagnostic and treatment delays can be reduced to improve the prognoses of the cancer patients. Cancer waiting time may still be important as indicators of overall performance of a health service. Objective: The aim of this study was to investigate the association of waiting time for diagnosis with quality of life in nasopharyngeal carcinoma. Methods: A cohort survey was done in six months from July to December 2019. We conducted new patients whom never had any therapy from other care centers. Data were collected two times using the structured interview technique by using EORTC QLQ-C30 and QLQ-H&N43 questionnaires. We counted the time for diagnosis from the first time the patient came for diagnostic until the first therapy for the cancer. Results: The eligible samples were 24 patients. Their mean (SD) and median ages were 46.71 (10.1) and 49.0 years respectively and waiting time for diagnosis was 34.2 (10.4) and 31.0 days. The patient’s scored <33.3 for global health status in first came to the hospital (pre-test) was 66.7%. In pre-test, diarrhea and constipation were the most disturbing symptoms and the post-test were loss of appetite and dyspnea. Time for diagnosis was statistically significant with global health (P<0.05). Global health has significant differences in the pre-test and post-test. Conclusion: The nasopharyngeal carcinoma patients in our institution had a worse quality of life regarding overall status. Waiting time for diagnosis has association with global health score in quality of life (QoL). Further research is required to investigate the clinical patient during waiting period for diagnosis.
Co-Authors Fifi Dwijayanti Nuryanti Samosir