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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia
Mardhani YS
Lab/SMF Ilmu Kesehatan Anak FK Unibraw/RSU Dr. Saiful Anwar Malang
Medicine & Pharmacology

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Identification of point mutations in Glucose-6-Phosphate Dehydrogenase gene in Timor Island people : A preliminary report Hardjowasito, Widanto; Pardjianto, Bambang; Fitri, Loeki E.; Ys, Mardhani; M., Loekito R.; Shirakawa, Taku; Nishiyama, Kaoru; Matsuo, Masafumi
Medical Journal of Indonesia Vol 10, No 4 (2001): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (493.394 KB) | DOI: 10.13181/mji.v10i4.35

Abstract

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is common in malaria endemic region, however no molecular study has been performed on G6PD deficiency in Timor Island, Indonesia a malarial hyperendemic area which Proto Malay is the majority of the people in that island. To observe the frequency and molecular type of mutations in G6PD deficient Proto Malay people, 118 native people were screened using formazan ring test. Mutation in the G6PD gene were determined by MPTP (Multiple PCR using Multiple Tandem Forward Primers and a common Reserve Pimer) method and confirmed by automatic sequencer. This study shows that three males have lower G6PD activity. Using MPTP method, a point mutation could be indicated in the two cases. Sequencing of the amplified products in 2 G6PD patients disclosed mutations of T383C in exon 5 and C 592 T in exon 6 in respective case. Our result documents point mutations in exon 5 and exon 6 in the G6PD gene of two Proto Malay people in Timor. These mutations are common in Asia region. (Med J Indones 2001; 10: 210-3)Keywords: mutations, G6PD, Proto Malay.
GAMBARAN KLINIS DAN LABORATORIUM SINDROM SYOK DENGUE RAWAT PICU RSU DR. SAIFUL ANWAR MALANG Budhy, Setya; YS, Mardhani; Muid, Masdar
Jurnal Kedokteran Brawijaya Vol 20, No 2 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (124.301 KB) | DOI: 10.21776/ub.jkb.2004.020.02.3

Abstract

ABSTRACT Dengue shock syndrome (DSS) is a clinical emergency case with still high mortality rate. During five years period (1January 1997?31 December 2001) total case of SSD triaded in PICU room Medical Faculty Brawijaya University/ Saiful Anwar Hospital Malang were thirty two patients. They were referred from Malang regency 9 patients (28%), Malang city 23 patients (72%). The most group age 6 ? 10 years 14 patients (44%), < 5 years 13 patients (41%), 11 ? 14 years 5 patients (15%). SSD is devided in DBD grade III 14 patients (44%), DBD grade IV 18 patients (56%). Laboratory finding total leucocyt count < 4000/mm3 8 patients (25%),  4000 ? 10000/mm3 24 patients (75%). Total thrombocyt < 50000 / mm3 22 patients (69%), 50000 ? 100000/ mm3 10 patients (31%). Hematocrit > 42% all patients (100%). Clinical sign found in SSD patients quickly and fine pulse 14 patients (44%), cold extremities 32 patients (100%), pulse not palpable 18 patients (56%). Blood tension : unmeasured 18 patients (56%), hypotension 18 patients (56%). Death patients 13 (41%) recovery patients 19 (59%). All SSD patients  (100%)  were death by complication of occult bleeding, pulmonary edema, respiratory failure.
Co-Authors Bambang Pardjianto Kaoru Nishiyama Loeki E. Fitri Loekito R. M. Masafumi Matsuo Masdar Muid Setya Budhy Taku Shirakawa Widanto Hardjowasito