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All Journal Jurnal Radioisotop dan Radiofarmaka Jurnal Manajemen Perbankan Keuangan Nitro Mount Hope Global Economic Journal
Veronika Yulianti
Pusat Pengembangan Radioisotop dan Radiofarmaka, BATAN, Serpong.
Economics, Econometrics & Finance Medicine & Pharmacology

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OPTIMALISASI PEMBUATAN KIT IRMA CA-125 Ariyanto, Agus; Darwati, Siti; Mondrida, Gina; Yunita, Fitri; Widayati, Puji; Setiyowati, Sri; Sulaiman, Sulaiman; Yulianti, Veronika; Triningsih, Triningsih
Jurnal Radioisotop dan Radiofarmaka Vol 6, No 2 (2003): Jurnal PRR 2003
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ABSTRAK OPTIMALISASI PEMBUATAN KIT IRMA CA-125. Telah dilakukan penelitian optimalisasi pembuatan kit  IRMA  CA-125 yang meliputi pembuatan perunut monoklonal anti CA-125 bertanda 125I dan  pembuatan  "coated tube". Pada pembuatan perunut digunakan 2 macam oksidator yang divariasikan jumlahnya, yaitu kloramin-T dan N- bromosuksinimid.  Optimalisasi pembuatan "coated tube" dilakukan dengan memvariasikan volume larutan "coating", pengaruh pencucian, pengaruh penambahan BSA, pengaruh   bufer  pelarut dan uji pemasangan monoklo-nal anti CA-l25. Hasil percobaan menunjukkan bahwa oksidator  kloramin-T dapat digunakan untuk pembuatan perunut mononoklonl  anti CA-l25 dengan rendemen cukup tinggi yaitu 96.5% dan kemumian radiokimia 93,2%. Jumlah oksidator yang optimal adalah 10 µg. Pembuatan "coated tube  untuk  monoklonal anti CA-l25 dengan menggunakan volume larutan "coating" yang bervariasi antara 300 µI sampai dengan 600 uL tidak menunjukkan perbedaan nyata pada nilai %NSB dan %BT. Proses pencuci "coated tube" menggunakan BSA 0, I % memberikan pengaruh nyata pada %BT. walaupun tidak berpengaruh terhadap nilai %NSB. Penggunaan bufer bikarbonat untuk pembuatan "coated tube" memberikan hasil yang lebih baik dari pada bufer fosfat. Untuk pemasangan monoklonal anti CA-125 diketahui bahwa pasangan monoklonal anti CA-125. monoklonal anti CA-125  M37203M sebagai  perunut dan monoklonal anti CA-125  M86924M sebagai "coating solution" memberikan hasil yang optimal. Kata kunci : Kit IRMA, Monoklonal anti CAll25, Pemnut ABSTRACTOTIMALIZATION FOR PREPf\RATION OF CA-125 IRMA-KIT. Optimalization on thepreparation of CA-125 IRMA-kit has been studied involving preparation of 125I  labeled monoclonalanti CA-125 as a tracer and preparation of coated tubes. Chloramine-T and N-bromosuccinimide were used as oxidators by varying them in their quantity. Optimalization on preparation of coated tube was carried out by variation in volume of  coating solution, effect of washing, addition of BSA 0.1%, buffer and pairing test for the monoclonal anti CA-125. The use of chloramine-T as oxidator for 125I labeling of monoclonal anti CA-15 was found to giv labeling-yield of about 96.5% and radiochemical purity of 93.2%. Optiimum amount of the oxidizing agent was found to be 10µg. There were not any significant difference in utilization of coating solution volume ranging at 300 to 600µL. for preparing monoclonal anti CA-125 coated tube. The non specific binding (NSB) and the %B/T values were found to be unaffected  by washing step, while a blocking of coated tube using of BSA 0.1% decreased the %B/T value. Utilization of bicarbonate buffer for the preparation  of coated tube was found to be more satisfactory than that of phosphate buffer. It was shown that the monoclonal anti CA-125 M37203 used for tracer being paired with monoclonal anti CA-125 M866924M used for coating solution gave an optimal result based on the values of %NSB  and %B/T. Key word : IRMA-Kit, Monoclonal anti CA-125, Tracer.   
FORMULASI KIT MIBI SEBAGAI PREPARAT PENATAH JANTUNG Widyastuti, widyastuti; A., Hanafiah; Yunilda, Yunilda; A., Laksmi; Setiyowati, Sri; Yulianti, Veronika
Jurnal Radioisotop dan Radiofarmaka Vol 2, No 1/2 (1999): JURNAL PRR 1999
Publisher : Jurnal Radioisotop dan Radiofarmaka

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FORMULASI KIT MIBI SEDAGAI PREPARAT PENATAH JANTUNG. Sediaan 2-methoxy-isobutyl-isonitrile (MIBI) telah diketahui sebagai preparat penatah perfusi miokardial (otot jantung) yang telah ditandai dengan 99mTc. Sediaan ini menghasilkan gambaran yang sama baiknya dengan sediaan Talium-201Tl, dan dapat menggantikan sediaan 201Tl karena mempunyai beberapa keunggulan. Kit MIBI ini dibuat dari senyawa MIBI yang disintesis di P2RR-BATAN yang telah melalui karakterisasi dan serangkaian uji kualitas. Formula kit MIBI yang digunakan mengacu pada formula yang digunakan oleh produk impor (CardioliterR, kit MIBI buatan Dupont), dan pengujian kualitas dilakukan dengan membandingkan beberapa parameter terhadap produk impor tersebut. Parameter yang digunakan dalam uji kualitas ini meliputi kemurnian radiokimia, biodistribusi (perbandingan % radioaktivitas di jantung dan hati), dan gambaran organ menggunakan gamma kamera pada manusia. Hasil percobaan menunjukkan kemurnian radiokimia rata-rata 95%, biodistribusi di jantung dan hati memberikan rasio 0,7, 1,5 dan 2,53 berturut-turut pada waktu pencacahan 10, 30 dan 60 menit setelah penyuntikan. Hasil pengujian pada manusia menunjukkan gambaran yang sangat jelas dan kurang lebih sama dengan yang dihasilkan oleh produk impor. Dari percobaan ini telah diketahui pula kondisi pengeringan kit yang baik, yang menghasilkan kit dengan kekeringan yang cukup baik dan waktu daluwarsa lebih dari 6 bulan. FORMULATION OF MIBI KIT AS A HEART IMAGING AGENT. 99mTc labelled 2-methoxy-isobutyl-isonitrile (MIBI) has been known as an imaging agent for myocardial perfusion. This radiopharmaceutical preparation gives the same satisfactory result as Thalium-201Tl, and presumably could replace 201Tl because of some advantages. MIBI kit was formulated from MIBI ligand produced by RPC­ BATAN which has been characterized and tested for quality. The formula used in this research referred to the formula of imported product (Cardiolite, MIBI kit produced by Dupont), and the quality control testing was performed by comparing some parameters to the imported product. The parameters used for QC testing were radiochemical purity, biodistribution in mice and heart imaging in human volunteer using gamma camera. The result of the experiment showed that the radiochemical purity was 95 % in average, biodistribution in heart to liver gave the ratio of 0.67, 1.5 and 2.53 respectively at 10, 30 and 60 minutes after injection. The result of clinical testing in some volunteers gave contrast images as good as given by Cardiolite. The optimum condition of freeze drying has been found, and the kit can be used for more than 6 month.
FAKTOR-FAKTOR YANG MEMPENGARUHI SUKU BUNGA PINJAMAN MODAL KERJA, TINJAUAN PADA BANK PEMERINTAH DAERAH DI INDONESIA Yulianti, Veronika; Dedy
Mount Hope Economic Global Journal Vol. 2 No. 3 (2024)
Publisher : Institut Teknologi dan Bisnis Kristen Bukit Pengharapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61696/mega.v2i3.556

Abstract

This study aim to determine the effect of Working Capital Loan Interest Rate, Inflation, Population Growth Rate and sight of Local Government Bank in Indonesia. In addition, there is also a balance or relationship between free variables and non-free variables in this research model, in case for long term or short term within using multiple linier regression method. The increase of population growth rate make working capital also increase, especially at Local Government Bank in Indonesia. The data that use in this research is secondary data’s for annual between Januari 2019 until December 2023 that published by Central Statistics Agency either Population Growth Rate, and Indonesian Bank either Inflation Rate and Working Capital Loan Interest Rate. The types of The loan distribution in question is the Working Capital Loan Interest Rate. The results of this study show that inflation has an effect on working capital loan interest rates because high inflation rates can have an impact on banking interest rates. Similarly, the rate of population growth has a significant effect on the interest rate on working capital loans because the rate of population growth will increase the demand for goods and services.
ANALISIS FUNDAMENTAL PERBANDINGAN HARGA SAHAM BBRI DAN BBCA DI INDONESIA TERHADAP ISU KEBIJAKAN KENAIKAN TARIF TRUMP Yulianti, Veronika; Hari , Aloysius Hari Kristianto; Dedy, Dedy
Jurnal Manajemen Perbankan Keuangan Nitro Vol. 8 No. 2 (2025): Volume 8, Nomor 2, July 2025
Publisher : LP2M IBK Nitro

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Abstract

The trade war started with the policies of Donald Trump's presidential administration. The current political situation can affect stock returns, as well as economic policies that can affect stock price movements. This research is a quantitative study that has the purpose of this study to observe banking stocks by comparing stock prices whether it affects BBRI and BBCA after the trump tariff policy. The research method used is descriptive quantitative method as a research approach. The calculation for data analysis techniques uses fundamental analysis by observing the comparison of standard deviation, income statement, balance sheet, and cash flow. Data sources were obtained from stockbit.com. in this study the value of BBRI and BBCA shares is still within the average value of 4000 & 8000, meaning that as an investor this stock is worth buying. Keywords: trade war, United States, imports, Donald Trump, and banking
Co-Authors Agus Ariyanto Dedy dedy dedy, dedy Fitri Yunita Gina Mondrida Hanafiah A. Hari , Aloysius Hari Kristianto Laksmi A. Puji Widayati Siti Darwati Sri Setiyowati Sulaiman Sulaiman Triningsih Triningsih Widyastuti Widyastuti Yunilda Yunilda