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All Journal Indonesian Journal of Urology Mutiara Medika: Jurnal Kedokteran dan Kesehatan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Journal of Comprehensive Science
Yuningtyaswari Yuningtyaswari
Department of Histology, Faculty of Medicine and Health Science/Muhammadiyah University, Yogyakarta.
Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health

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 1 
THE IGF-1 LEVEL OF ESRD PATIENTS AND ITS RISK FACTORS Hidayati, Titiek; Yuningtyaswari, Yuningtyaswari; Sadewa, Ahmad Hamim; Soesatyo, Marsetyawan HNE
Indonesian Journal of Urology Vol 21 No 1 (2014)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v21i1.24

Abstract

Objective: To identify the Insulin-like Growth Factor–1 (IGF-1) level of End Stage Renal Disease (ESRD) and non ESRD populations, and correlation between IGF-1level and ESRD incidences. Material & Method: This case study was carried out in Yogyakarta with 72 volunteers. The cases involved Chronic Kidney Disease (CKD) patients. The controls were non-CKD patients. CKD parameters were established with PERNEFRI diagnostic criteria. Comparison of IGF-1 levels between case and control groups was performed through ANOVA, with confidence level of 95%. Bivariate analysis to identify the correlation between IGF-1 plasma level, smoking status, illness history and body mass index (BMI) by determining odds ratio (OR) of individual risk factor of p < 0.05. Results: We enrolled 72 volunteers, 45 male and 27 female subjects. Of the 45 male patients, 15 CKD and 30 non CKD patients served as cases and controls, respectively. The difference in plasma IGF-1 level was detected in the case and control groups (42.01 ± 10.66 vs. 56.05 ± 24.91) (p < 0.05). The result of bivariate analysis showed passive smoking status, IGF-1 plasma level, DM history and hypertensive illness history had correlation with ESRD incidence with odds ratios of 7.88 (p < 0.005; CI: 1.6-37.5) for passive smokers, 4.3 (p < 0.05, CI: 1.36 to 13.33) for IGF-1 level, 21.5 (p < 0.05; CI) for DM history and 12.4 (p < 0.05; CI: 3.7 to 41) for hypertensive history. Conclusion: There was difference in IGF-1 plasma level between ESRD and non-ESRD patients. The IGF-1 plasma level, passive smoking status, diabetes history, and hypertensive history have correlation with ESRD incidence.Keywords: Insulin-like Growth Factor–1 level, End Stage Renal Disease, case control, odds ratio.
Pengaruh Paparan Pengharum Ruangan Cair dan Gel terhadap Gambaran His-tologi Pulmo pada Tikus Putih (Rattus norvegicus) Yuningtyaswari, Yuningtyaswari; Haryani, Asti
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i1.2498

Abstract

Pengharum ruangan adalah produk yang mengandung bahan kimia bertujuan mengurangi bau yang tidak menyenangkan di ruangan tertutup. Pengharum ruangan modern tersedia dalam bentuk cair (aerosol) dan gel. Pengharum ruangan mengandung zat adiktif dan pelarut seperti 1,4-dichlorobenzene yang dapat mempengaruhi fungsi pulmo (paru-paru). Tujuan penelitian ini untuk mengkaji pengaruh dan perbedaan paparan pengharum ruangan berbentuk cair dan gel terhadap gambaran histologi pulmo Rattus norvegicus.  Desain penelitian yaitu post-test only control group. Post test dilakukan dengan mengamati gambaran histologi pulmo tikus putih setelah pemaparan pengharum ruangan cair dan gel selama 8 jam/hari dalam jangka waktu 15 hari. Subyek penelitian ada 18 ekor tikus putih. Data diuji dengan menggunakan uji statistik One Way ANOVA dilanjutkan dengan Post Hoc Tukey. Hasil penelitian didapatkan perubahan gambaran histologi pulmo, terutama alveolus tikus putih berupa penebalan septum interalveolar. Analisis data perbandingan antara kelompok kontrol dan perlakuan secara statistik didapatkan p=0,000 artinya terdapat pengaruh dan perubahan bermakna pada pulmo tikus putih yang dipaparkan pengharum ruangan berbentuk cair dan gel. Secara histologi terdapat perbedaan gambaran histologi antara kelompok cair dan gel. Disimpulkan efek pengharum ruangan pada kelompok gel lebih buruk dibandingkan kelompok cair walaupun secara statistik tidak bermakna.            Air freshener is a product that contains chemical substance to lose the odor in closed room. Modern air freshener available in form of liquid (aerosol) and gel. It contains addictive material and solvent such as 1,4-dichlorobenzene that can influence the function of pulmo. The aims to know the influences and the differences of air freshener exposure in form of liquid and gel towards Rattus norvegicus pulmo histological image. Research design used post-test only control group design method. Post test is conducted by observing pulmo’s rat histological  image after gel and liquid air freshener exposure during 8 hours/day in 15 days.  Research subject is 18 rats. Data is analyzed by One Way ANOVA and continued by Post Hoc Tukey. The result of the research shows that there’s changing on pulmo histological image especially in the alveolus that is the thickening of the septum alveolar. P value between control group and others group is p=0,000. It means that there’s significant influences and changes in rat’s pulmo that is exposured by gel and liquid air freshener. Conclude effects of the gel group is worst than liquid group although statistically there’s no significant differences
Perbandingan Pengaruh Pendedahan Uap Bensin Jenis Pertamax Dan Premium Terhadap Gambaran Histologi Bronkus Tikus Putih (Rattus Norvegicus) Jantan Muhartiningsih, Sitilia; Yuningtyaswari, Yuningtyaswari
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 6, No 1 (2019): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (810.652 KB) | DOI: 10.26714/magnamed.6.1.2019.19-30

Abstract

Comparison of the Effect of Exposure to Gasoline Vapors of Pertamax and Premium Types on Histological Appearance of Male White Rat (Rattus Norvegicus) BronchiLatar belakang: Bensin yang tersedia di Indonesia adalah bensin jenis Premium dan Pertamax. Bensin Premium mengandung tetra-etil-lead yang terkandung timbal dengan nilai oktan 88 sedangkan Pertamax mengandung metil-tertil-butil-eter atau etil-tertil-butil-eter sebagai pengganti timbal dengan nilai oktan 92. Senyawa benzena dan timbal merupakan senyawa berbahaya yang mempengaruhi sistem pernapasan seperti bronkus. Tujuan: Penelitian ini untuk mengetahui pengaruh pendedahan uap bensin jenis Premium dan Pertamax terhadap gambaran histologi bronkus tikus putih (Rattus norvegicus). Metoda: Subyek penilitian 27 ekor tikus putih (Rattus norvegicus) jantan, berumur 8 minggu dengan berat 150-220 gram. Subyek dibagi menjadi tiga kelompok yaitu kelompok kontrol (K), Pertamax (P1) dan Premium (P2). Pada kelompok P1 dan P2 diberikan pendedahan uap bensin 8 jam/hari selama 30 hari dan kelompok K (tidak diberikan perlakuan). Hasil: Rata-rata  ketebalan epitel bronkus kelompok K (25,2211±3,20932) µm; P1 (28,4411±2,82673) µm; dan P2 (31,5422±4,11304) µm. Uji Tukey menunjukkan perbedaan ketebalan epitel yang signifikan antara kelompok K dan P2 dengan p=0,002. Rata-rata diameter bronkus kelompok K (1284,78±97,778) µm; P1 (1054,67±159,625) µm dan P2 (978,22±219,136) µm. Uji Tukey menunjukkan perbedaan panjang diameter bronkus yang signifikan antara kelompok K dan P1 dengan p=0,021, sedangkan kelompok K dan P2 dengan p=0,002. Rata-rata jumlah sel goblet kelompok K (6,7778±0,7362); P1 (9,9444±0,99041) dan P2(11,6356±0,47276). Uji Tukey menujukkan perbedaan jumlah sel goblet yang signifikan antara kelompok K, P1 dan P2 dengan p=0,000. Simpulan: Pendedahan uap bensin kelompok P1 dan P2 mempengaruhi gambaran histologi berupa ketebalan epitel, diameter bronkus dan jumlah sel goblet pada tikus putih (Rattus norvegicus) jantan. Background: Premium and pertamax are types of gasoline which are mostly consumed in Indonesia. Premium gasoline contains lead and has an octan number 88 while, Pertamax gasoline containing methyl tertiary butyl ether (MTBE) or ethyl tertiary butyl ether (ETBE) as a substitute for lead with an octane number 92. Benzene and lead compound are the dangerous compound that can affect to respiratory system such as bronchi.Objective: This study aims to determine the effect of Premium and Pertamax gasoline vapor exposure to bronchial histology of the white rat (Rattus norvegicus).Method: Subjects of the experiment were 27 white male rats (Rattus norvegicus), 8 weeks old, having weight 150-220 grams. Subjects were divided equally into three groups: control group (K), Pertamax group (P1) and Premium group (P2). The subjects (samples) from Premium group and Pertamax group were exposed to the gasoline vapor for 8 hours per day in 30 days and the control group was exposed to normal environment.Result: The results of the average number of bronchial epithelial thickness are (25.2211 ± 3.20932) μm for K group; (28.4411 ± 2.82673) μm for P1 group and (31.5422 ± 4.11304) μm for P2 group. Attractions Tukey test found significant difference in the K group and P2 group with p=0.002. The result of the average number of diameter are (1284,78±97,778) μm for K group; (1054,67±159,625) μm for P1 group and (978,22±219,136) μm for P2 group. Attractions Tukey test found significant difference in the K and P1 group with p=0,021, although K dan P2 group with p=0,002. The result of the average number of goblet cell are (6,7778±0,7362) for K group; (9,9444±0,99041) for P1 group and (11,6356±0,47276) for P2 group. Attractions Tukey test found significant difference in the K, P1 and P2 group with p=0,000.Conclusion: P2 and P1 gasoline vapor exposure have affect on the bronchial histology from the thickness of the bronchial epithelium, diameter sum of bronchus and in white male rats (Rattus norvegicus).
Pengaruh Ekstrak Rambut Jagung (Zea mays L.) Terhadap Gambaran Histologi Ginjal Tikus Putih yang Diinduksi Alkohol (Studi in vivo pada Rattus norvegicus) Yuningtyaswari, Yuningtyaswari; Fitria Hidayati, Ashfi
Journal of Comprehensive Science Vol. 4 No. 2 (2025): Journal of Comprehensive Science (JCS)
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v4i2.3006

Abstract

Alcoholic beverages contain ethanol, which is toxic and can increase oxidative stress, potentially damaging the kidneys. Corn silk contains flavonoids with antioxidant effects. This study aims to examine the effect of corn silk extract on the kidney histology of alcohol-induced white rats. This experimental study used a post-test only control group design with 36 rats divided into 9 groups: control (C), negative control (P) receiving 1 ml/day of alcohol, positive control (J1, J2, J3) receiving corn silk extract at doses of 50, 100, and 150 mg/KgBW, treatment groups (PJ1, PJ2, PJ3) induced with alcohol and then given corn silk extract, and the comparator group (S) induced with alcohol and given 1 ml of vitamin C. Kidney histological damage was assessed based on glomerular and tubular damage scores. Data were analyzed using One Way ANOVA and post hoc Duncan tests. The results showed the average kidney damage scores for groups C = 43.35; P = 54.55; J1 = 46.75; J2 = 47.20; J3 = 46.45; PJ1 = 50.75; PJ2 = 46.35; PJ3 = 47.20; and S = 46.90. The glomerular and tubular damage scores of group C differed significantly from P but were not significantly different from other groups. Thus, the administration of corn silk extract (Zea mays L.) does not have a significant effect on the histological appearance of the glomerulus and renal tubules in alcohol-induced white rats (Rattus norvegicus). However, there is a tendency indicating that this extract has the potential to reduce alcohol-induced damage, although the observed differences are not statistically significant.
The Effect of Using Absorbent Carbon on Air Exposed to Air Fresheners on The Histology of The Cornea of The White Rat (Rattus Novergicus) Yuningtyaswari, Yuningtyaswari; Susanti, Tisa
Journal of Comprehensive Science Vol. 3 No. 8 (2024): Journal of Comprehensive Science (JCS)
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v3i8.854

Abstract

Air freshener contain hazardous chemical such as formaldehyde. Absorbent carbon is used as an adsorbent to reduce air pollution. The goal of this research is to know the use of absorbent carbon to cornea histology on Rattus novergicus that was induced with air freshener. This research was an experimental study with a post-test only control group. The subjects were 28 one-month old male Rattus novergicus Wistar strains divide into 4 groups: Control (K), air freshener (P1), absorbent carbon (P2) and air freshener plus absorbent carbon (P3).The treatment was performed 8 hours/day for 35 days. Data of anterior epithelial thickness were analyzed by One Way Anova test. Data of the overall thickness of the corneal layer and keratocyte number were analyzed by Kruskal Wallis test. The overall thickness of the corneal layer and anterior epithelial thickness showed that there were not significant difference between subject groups (p>0,05). Anterior epithelial thickness showed that there were not significant difference between subject groups (p>0,05). Keratocyte number showed significant difference between subject groups (p<0,05), Mann Whitney test for Keratocyte number showed results P1>P3>K>P2 Absorbent carbon gives postitive effect to reduce cornea damage on Rattus novergicus that induced by air freshener.
Co-Authors Ahmad Hamim Sadewa Fitria Hidayati, Ashfi Haryani, Asti Marsetyawan HNE Soesatyo Muhartiningsih, Sitilia Susanti, Tisa Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati