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Tuti Wiyati
University of Muhammadiyah Prof. Dr. Hamka
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Aktivitas Ekstrak Etanol 70% Tongkol Jagung (Zea mays L.) Dalam Menurunkan Kadar Kolesterol Total dan LDL pada Hamster Hiperlipidemia Tuti Wiyati; Sri Harsodjo; Syella Nur Aulia
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 1 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.875 KB) | DOI: 10.15408/pbsj.v3i1.20526

Abstract

Tongkol jagung selama ini hanya dianggap sebagai limbah pangan dan masih sedikit pemanfaatannya. Tongkol jagung memiliki kandungan senyawa kimia flavonoid, tanin, dan saponin yang berkhasiat sebagai antihiperlipidemia. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol 70% tongkol jagung terhadap penurunan kadar kolesterol total dan LDL pada hamster jantan hiperlipidemia. Hamster dibagi menjadi 6 kelompok, yaitu kelompok I (kontrol normal), kelompok II (kontrol negatif), kelompok III (atorvastatin dosis 2,47 mg/kgBB), kelompok IV, V, VI (ekstrak tongkol jagung dengan dosis masing-masing secara berurutan: 150 mg/kgBB; 300 mg/kgBB; dan 600 mg/kgBB). Pemberian pakan tinggi lemak dilakukan untuk semua kelompok kecuali kelompok normal selama 28 hari masa perlakuan. Data persentase penurunan kadar kolesterol total dan LDL dianalisis dengan uji ANOVA satu arah dan dilanjutkan dengan uji Tukey. Hasil penelitian menunjukan bahwa ekstrak etanol 70% tongkol jagung dapat menurunkan kadar kolesterol total dan LDL (p<0,05). Dosis 600 mg/kgBB mempunyai aktivitas paling baik dalam menurunkan kadar kolesterol total dan LDL secara berurutan yaitu 35,48%; 36,36%. Namun aktivitas ini tidak sebanding dengan kontrol positif (atorvastatin). 
Korelasi Tingkat Pengetahuan Terhadap Keberhasilan Terapi Pasien Hipertensi di Puskemas Tuti Wiyati; Vera Rahayu; Septianita Hastuti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30231

Abstract

Knowledge can affect the success of therapeutic outcomes in hypertensive patients. Blood pressure must be controlled to prevent risk factors for other cardiovascular diseases. The purpose of this study was to analyze the relationship between knowledge of patients with hypertension and the success of therapy outcomes that showed controlled blood pressure. This observational cross-sectional study was conducted from March to June 2021 at Tangerang District Health Centers. A sample of 85 outpatients with hypertension was administered the HK-LS questionnaire to measure their level of knowledge, while the results of therapeutic outcomes were measured using blood pressure. The results showed that 60% of patients had intermediate knowledge and only 28.24% of the subjects had well-controlled blood pressure. There was a correlation between knowledge and therapy outcomes (p<0.05) with coef. correlation was -0.336, means a weak and inverse correlation. Comorbidity and sex were significantly correlated with knowledge (p<0,05). The level of knowledge needs to be improved to decrease the number of comorbidities or risk of complications to raise the goal of therapy. 
Co-Authors Septianita Hastuti Sri Harsodjo Syella Nur Aulia Vera Rahayu