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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Askal Maimulyanti
AKA Bogor Polytechnic
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Chemical Compounds of Coffee Ground and Spent Coffee Ground for Pharmaceutical Products Anton Restu Prihadi; Askal Maimulyanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 2 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.252 KB) | DOI: 10.15408/pbsj.v2i2.18338

Abstract

Coffee is one of the most valuable primary products in world trade. Coffee production generates a lot of coffee waste such as spent coffee grounds. The chemical components of the coffee ground and spent coffee ground were caffeine and chlorogenic acid. These components were important to apply in pharmaceuticals. This research conducted the identification of functional groups of coffee grounds and spent coffee grounds and analysis of the active compounds of caffeine and chlorogenic acid in the sample. Both samples have the same infrared spectrum and contain the main functional groups O-H, C-N, and C-H. The active substances in the spent coffee grounds were found to be caffeine 0.35% and chlorogenic acid 0.16%, while in coffee ground coffee before brewing it was obtained 1.41% caffeine and 1.50% chlorogenic acid. The waste of spent coffee grounds has a potential component and it can be used in pharmaceuticals.
Optimization Parameters of Natural Deep Eutectic Solvent Based on Choline Chloride and Fructose for Extraction of Polyphenol from Jotang (Spilanthes acmella) Stem Fajar Amelia Rachmawati Putri; Askal Maimulyanti; Isna Nurhidayati; Bella Mellisani; R. Wiwi Widarsih; Fitria Puspita; Anton Restu Prihadi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 1 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.39583

Abstract

Natural deep eutectic solvents (NADES) have become popular as an environmentally benign alternative to conventional solvents for extracting natural compounds. In this current research, choline chloride was employed as a hydrogen bond acceptor (HBA) and was mixed with fructose which had the role of a hydrogen bond donor (HBD) to construct NADES. This extracting agent was deployed to separate the polyphenolic compounds from the stem of Jotang (Spilanthes acmella) under prime conditions. The extracted polyphenol was subsequently calculated based on the Folin-Ciocalteu method using gallic acid as the standard solution by UV-Vis spectrophotometer at 760 nm. Corresponding to the research outcomes, the most gainful states of extraction were achieved at a sample weight-to-NADES volume ratio of 1:50, a period of extracting process of 60 min, water content of 20%, and a stirring speed of 80 rpm. The optimized parameters were conceived as the most gainful because they exhibited the most prominent level of polyphenol were described as follows: ratio of sample weight-to-NADES volume and extraction time showed polyphenol content of 25.13 mg GAE/g each, while the others, stirring speed and water content revealed the polyphenol concentration of 25.75 mg GAE/g respectively.
Co-Authors Anton Restu Prihadi Anton Restu Prihadi Bella Mellisani Fajar Amelia Rachmawati Putri Fitria Puspita Isna Nurhidayati R. Wiwi Widarsih