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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Fitria Puspita
AKA Bogor Polytechnic
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Optimization Parameters of Natural Deep Eutectic Solvent Based on Choline Chloride and Fructose for Extraction of Polyphenol from Jotang (Spilanthes acmella) Stem Fajar Amelia Rachmawati Putri; Askal Maimulyanti; Isna Nurhidayati; Bella Mellisani; R. Wiwi Widarsih; Fitria Puspita; Anton Restu Prihadi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 1 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.39583

Abstract

Natural deep eutectic solvents (NADES) have become popular as an environmentally benign alternative to conventional solvents for extracting natural compounds. In this current research, choline chloride was employed as a hydrogen bond acceptor (HBA) and was mixed with fructose which had the role of a hydrogen bond donor (HBD) to construct NADES. This extracting agent was deployed to separate the polyphenolic compounds from the stem of Jotang (Spilanthes acmella) under prime conditions. The extracted polyphenol was subsequently calculated based on the Folin-Ciocalteu method using gallic acid as the standard solution by UV-Vis spectrophotometer at 760 nm. Corresponding to the research outcomes, the most gainful states of extraction were achieved at a sample weight-to-NADES volume ratio of 1:50, a period of extracting process of 60 min, water content of 20%, and a stirring speed of 80 rpm. The optimized parameters were conceived as the most gainful because they exhibited the most prominent level of polyphenol were described as follows: ratio of sample weight-to-NADES volume and extraction time showed polyphenol content of 25.13 mg GAE/g each, while the others, stirring speed and water content revealed the polyphenol concentration of 25.75 mg GAE/g respectively.
Comparative Phytochemical Evaluation of Indonesian Single-Origin Arabica Coffees: Caffeine, Total Phenolic Content, and DPPH Antioxidant Activity Ahmad Dzaky Mualim; Fitria Puspita
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.51354

Abstract

Coffee (Coffea arabica) is a globally significant commodity, and Indonesia's diverse archipelagic geography produces beans with distinct origin-associated characteristics. Although the antioxidant properties of coffee are well-documented, the influence of specific geographical origins on its secondary metabolites is less understood. This study aims to investigate the variations in Total Phenolic Content (TPC), caffeine concentration, and antioxidant activity (IC50) across eight prominent Indonesian single-origin Arabica coffees: Aceh Gayo, Ciwidey, Papua Wamena, Bali Kintamani, Kerinci, Toraja, Bajawa, and Temanggung. Utilizing standardized medium-roast samples and ethanolic extraction, the phytochemical profiles were quantified and statistically analyzed via one-way ANOVA and linear regression. The results revealed significant variations (p < 0.001) across all measured parameters based on geographical origin. High-altitude coffees, specifically from Ciwidey and Papua, exhibited the highest TPC (up to 42.72 mg GAE/g) and the most potent antioxidant activity (IC50 of 40.15 ppm and 44.90 ppm, respectively). Conversely, Temanggung coffee, cultivated at lower elevations with nutrient-rich volcanic soil, demonstrated the highest caffeine concentration (1.31%) but the lowest TPC and antioxidant capacity. A strong linear correlation (R2 = 0.793) between TPC and antioxidant activity confirms that phenolic compounds are the primary drivers of radical scavenging efficacy. Ultimately, this study demonstrates that geographical origin significantly shapes the chemical profile and antioxidant capacity of Indonesian Arabica coffees, providing a practical scientific framework for origin authentication and quality evaluation.
Co-Authors Ahmad Dzaky Mualim Anton Restu Prihadi Askal Maimulyanti Bella Mellisani Fajar Amelia Rachmawati Putri Isna Nurhidayati R. Wiwi Widarsih