Articles
<![CDATA[Hypnosis for Pain Alleviation: Placebo or Nocebo? ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Jeremy Putra Gunawan]]>;
<![CDATA[Astrella Devina]]>;
<![CDATA[Wibi Sindjaja]]>;
<![CDATA[Jesslyn Pavita]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v46i2.527
<![CDATA[The use of hypnosis to alleviate pain had started to gain recognition. In the assessed papers, application of hypnosis has included childbirth, surgeries, and chronic pain. In childbirth, the use of self-hypnosis can reduce the use of analgesics from 78% to 45% of cases. The satisfaction of hypnobirthing—birth using hypnosis—reaches 96%. Hypnosis can decrease the use of anesthesia drugs during surgery, promotes healing, decreases bleeding and hospital stay. Hypnosis can alleviate pain and reduce the use of over the counter painkillers; also showed benefits for non-cardiac chest pain relief while also reduces medication. Currently, hypnosis had been the most prominent application for labour pain relief. There is a demand for more studies of bioinformatics and neuroscience.Penggunaan hipnosis untuk mengurangi rasa sakit sudah mulai mendapat pengakuan. Banyak pustaka menjelaskan penerapan hipnosis pada proses melahirkan, operasi, dan nyeri kronis. Pada proses melahirkan, self-hypnosis dapat mengurangi penggunaan analgesik dari 78% menjadi 45% kasus. Kepuasan hypnobirthing – kelahiran menggunakan hipnosis - mencapai 96%. Hipnosis dapat mengurangi penggunaan obat anestesi, mempromosikan penyembuhan, mengurangi perdarahan dan lama rawat di rumah sakit pasca-operasi. Hipnosis bisa mengurangi penggunaan obat penghilang nyeri; juga menunjukkan manfaat untuk penderita nyeri dada non-jantung selain mengurangi konsumsi obat. Saat ini, aplikasi hipnosis yang paling menonjol untuk nyeri persalinan. Diperlukan studi bioinformatika dan neuroscience lebih lanjut.]]>
<![CDATA[Therapeutic Effect of Avocatin B in Avocados Toward Acute Myeloid Leukemia ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Anthony Ryan Pantoni]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 45, No 11 (2018): Neurologi ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i11.564
<![CDATA[Acute myeloid leukemia is the abnormal division of immature myeloid precursor cells in the bone marrow affecting mostly older people. Till date, there are no potent treatments due to the fact that it cannot target leukemic stem cells which are responsible for relapse and initiation of leukemia. Current treatments can also pose side effects that might to be too harsh for older people. Avocatin B is a lipid derived from avocado that can be a novel potent drug to replace or go along with the current therapies. Avocatin B is able to induce leukemic cell death and their stem cells while leaving normal cells unharmed. Their mechanisms of actions include inhibiting fatty acid oxidation which causes reactive oxygen species mediated apoptosis and lipotoxicity. Their selectivity towards leukemic cells over normal cells are due to the fact that they are able to target leukemic mitochondria which are different from the normal cells’ mitochondria in terms of their metabolic pathways.Leukemia myeloid akut merupakan sel precursor myeloid dalam sumsum tulang dewasa yang abnormal. Hingga saat ini, belum ada terapi yang tepat untuk leukemia myeloid akut. Avocatin B adalah lipid yang berasal dari alpukat, dapat menjadi obat baru atau digabungkan dengan terapi saat ini. Avocatin B mampu menginduksi kematian sel leukemia dan sel induknya. Mekanisme Avocation B meliputi penghambatan oksidasi asam lemak yang menyebabkan oksigen reaktif memediasi apoptosis dan lipotoksisitas. Selektivitas avocatin B terhadap sel-sel leukemia karena dapat menarget mitokondria penderita leukemia yang berbeda jalur metabolisme dari mitokondria sel-sel normal.]]>
<![CDATA[Primary Amebic Meningoenciphalitis (PAM) ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Siti Aisyah]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 44, No 12 (2017): Neurologi ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v44i12.687
<![CDATA[Naegleria fowleri is one of free-living amoeba that can be found around the world. It is also known as the causative agent of Primary Amebic Meningoencephalitis (PAM). PAM is a rare Central Nervous System (CNS) infection and can lead to fatal outcome. Since the first discovery, it becomes the problem worldwide. Misdiagnoses are common in PAM patient. The causative agent of PAM is living in the warm freshwater. Thus, the occurrence of this infection is high in summer and warmest season through the year. Due to its living characteristics, this amoeba has the potential to live in the Indonesia waters. The purpose of this review is to describe the difference between PAM and bacterial meningitis, epidemiology, diagnosis and prevention of PAM.Naegleria fowleri adalah salah satu amuba yang hidup bebas dan dapat ditemukan di seluruh dunia. N. fowleri dikenal sebagai agen penyebab Primary Amebic Meningoencephalitis (PAM). PAM merupakan infeksi langka yang menyerang sistem saraf pusat (SSP) dan dapat fatal. Sejak ditemukan telah menjadi masalah global. PAM sering salah didiagnosis. Agen penyebab PAM hidup di air tawar hangat; kejadian infeksi tertinggi saat cuaca terpanas. Karakteristik tersebut sesuai dengan iklim di Indonesia. Kajian ini diharapkan mampu menggambarkan perbedaan antara PAM dan meningitis yang disebabkan bakteri, epidemiologi, diagnosis dan pencegahan PAM.]]>
<![CDATA[Acne and Food Relation: A Naturopathic Perspective ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Ibdati Malika]]>;
<![CDATA[Samirah -]]>;
<![CDATA[Nadita Putri Almira]]>;
<![CDATA[Sheila Lestari]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v44i6.791
<![CDATA[Acne is a result of internal imbalance which appears in the form of inflammation, caused by the accummulation of oil, dirt and bacteria under the skin. Acne is the most prevalent skin disease and occurs in all ages, with the highest prevalence in adolescence. Naturopathy is the term for using prevention methods, based on the roots of the disease. This article is to review several scientific evidences on the association between acne and food. Thus, might support naturopathic perspective in acne prevention.Jerawat merupakan hasil ketidakseimbangan internal tubuh yang timbul dalam bentuk peradangan disebabkan oleh tumpukan minyak, kotoran, dan bakteri di bawah kulit. Jerawat merupakan penyakit kulit yang paling umum dan dapat menyerang segala usia,terutama remaja. Naturopati adalah istilah untuk penggunaan metode pencegahan penyakit berdasarkan akar penyebab. Artikel ini akan meninjau beberapa bukti ilmiah hubungan antara jerawat dan makanan. Hal ini dapat mendukung perspektif naturopati untuk mencegah jerawat.]]>
<![CDATA[Aldehyde-Low Endothelial Progenitor Cells in Ischemic Wound Repair, Regulated by SDF1/CXCR4 ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Candra Louis]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 45, No 12 (2018): Farmakologi ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i12.556
<![CDATA[The incidence rate of both ischemic heart disease and ischemic stroke over the past decade has become a concern in the respect of global mortality rate. Ischemia is a condition of oxygen deprivation in the specific tissue which leads to loss of organ function. Regenerative medicine by using the endothelial progenitor cells (EPCs) show a great potential, especially the Alde-Low EPCs. The Alde-Low EPCs are regulated mainly by the chemo-attractant proteins of SDF1/CXCR4 which responsible for the cell migration and is regulated by the HIF2α. Further investigation and research on the correlation of SDF1/CXCR4 and the Alde-Low EPCs are needed.Iskemi merupakan suatu kondisi pengambilan oksigen pada spesifik jaringan yang memicu kehilangan fungsi organ. Peningkatan kejadian dan kematian akibat penyakit jantung Ikemik dan stroke iskemik secara global pada beberapa dasawarsa telah menjadi perhatian. Upaya regenerasi menggunakan sel progenitor endothelial (EPCs) memperlihatkan potensi sangat tinggi, khususnya Alde- rendah EPCs. Alde-rendah EPCs diregulasi oleh protein chemoattractant dari SDF1/CXCR4 yang bertanggung jawab untuk migrasi sel dan diregulasikan oleh HIF2α. Hubungan SDF1/CXCR4 dan Alde-rendah EPCs masih perlu diteliti lebih lanjut. ]]>
<![CDATA[Significance of Lewy Body Formation in Development of Parkinson’s Disease ]]>
<![CDATA[Shivanki Sahay]]>;
<![CDATA[Dias Rima Sutiono]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i8.625
<![CDATA[Parkinson’s disease is a serious neurodegenerative disease characterized by depletion of neurons in the substantia nigra of the basal ganglia. These dying out neurons are found to contain traces of Lewy bodies, an abnormal protein filament of alpha-synuclein and that otherwise play an important role in the nervous system, especially at synapses.Penyakit Parkinson merupakan penyakit neurodegeneratif serius ditandai dengan deplesi neuron di substansia nigra ganglia basalis.Neuron ditemukan mengandung jejak Lewy Bodies, yang merupakan filamen protein abnormal alpha-synuclein. ]]>
<![CDATA[Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Fransiska Adeline]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi ]]>
Publisher : <![CDATA[PT. Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i9.616
<![CDATA[The Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting skin, musculoskeletal system and blood vessels, also other features supporting aging processes. This disease affects 1 in 4 - 8 million newborn all over the world without any race and gender preferences. The clinical features of HGPS usually appear in the age of two and will be discovered through clinical diagnosis. It then will be followed by health problems like coronary atherosclerosis that can be life-threatening. The life-span is usually 14,6 years. This review will discuss some emerging potential treatment such as FTI (Farnesyltransferase inhibitors).Sindrom Hutchinson-Gilford Progeria adalah penyakit genetik langka berupa penuaan lebih cepat pada usia anak-anak ditandai beberapa manifestasi di antaranya kulit, sistem muskuloskeletal dan pembuluh darah, serta hal lain sesuai proses penuaan. Penyakit ini terjadi pada 1 di antara 4-8 juta bayi baru lahir di seluruh dunia tanpa preferensi ras dan gender. Gambaran klinis HGPS biasanya muncul di usia dua tahun, diikuti masalah kesehatan seperti aterosklerosis koroner yang dapat mengancam jiwa. Rentang hidup biasanya 14,6 tahun. Ulasan ini mengenai beberapa pengobatan potensial seperti FTI (inhibitor Farnesyltransferase).]]>
<![CDATA[Hypnosis for Pain Alleviation: Placebo or Nocebo? ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Jeremy Putra Gunawan]]>;
<![CDATA[Astrella Devina]]>;
<![CDATA[Wibi Sindjaja]]>;
<![CDATA[Jesslyn Pavita]]>
<![CDATA[ Cermin Dunia Kedokteran Vol. 46 No. 2 (2019): Interna ]]>
Publisher : <![CDATA[PT Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v46i2.514
<![CDATA[The use of hypnosis to alleviate pain had started to gain recognition. In the assessed papers, application of hypnosis has included childbirth, surgeries, and chronic pain. In childbirth, the use of self-hypnosis can reduce the use of analgesics from 78% to 45% of cases. The satisfaction of hypnobirthing—birth using hypnosis—reaches 96%. Hypnosis can decrease the use of anesthesia drugs during surgery, promotes healing, decreases bleeding and hospital stay. Hypnosis can alleviate pain and reduce the use of over the counter painkillers; also showed benefits for non-cardiac chest pain relief while also reduces medication. Currently, hypnosis had been the most prominent application for labour pain relief. There is a demand for more studies of bioinformatics and neuroscience. Banyak pustaka menjelaskan penerapan hypnosis pada proses melahirkan, operasi, dan nyeri kronis. Pada proses melahirkan, self-hypnosis dapat mengurangi penggunaan analgesic dari 78% menjadi 45% kasus. Kepuasan hypnobirthing – kelahiran menggunakan hypnosis - mencapai 96%. Hipnosis dapat mengurangi penggunaan obat anestesi, mempromosikan penyembuhan, mengurangi perdarahan dan lama rawat di rumahsakit pascaoperasi. Hipnosis bisa mengurangi penggunaan obat penghilang nyeri; juga menunjukkan manfaat untuk penderita nyeri dada non-jantung selain mengurangi konsumsi obat. Saat ini, aplikasi hipnosis yang paling menonjol untuk nyeri persalinan. Diperlukan studi bioinformatika dan neuroscience lebih lanjut.]]>
<![CDATA[Aldehyde-Low Endothelial Progenitor Cells in Ischemic Wound Repair, Regulated by SDF1/CXCR4 ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Candra Louis]]>
<![CDATA[ Cermin Dunia Kedokteran Vol 45 No 12 (2018): Interna ]]>
Publisher : <![CDATA[PT Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i12.689
<![CDATA[The incidence rate of both ischemic heart disease and ischemic stroke over the past decade has become a concern in the respect of global mortality rate. Ischemia is a condition of oxygen deprivation in the specific tissue which leads to loss of organ function. Regenerative medicine by using the endothelial progenitor cells (EPCs) show a great potential, especially the Alde-Low EPCs. The Alde-Low EPCs are regulated mainly by the chemo-attractant proteins of SDF1/CXCR4 which responsible for the cell migration and is regulated by the HIF2α. Further investigation and research on the correlation of SDF1/CXCR4 and the Alde-Low EPCs are needed. Peningkatan kejadian dan kematian akibat penyakit jantung iskemik dan stroke iskemik secara global pada beberapa dasawarsa telah menjadi perhatian. Upaya regenerasi menggunakan sel progenitor endothelial (EPCs) memperlihatkan potensi sangat tinggi, khususnya Alde-rendah EPCs. Alde-rendah EPCs diregulasi oleh protein kemoatraktan dari SDF1/CXCR4 yang bertanggung jawab untuk migrasi sel dan diregulasikan oleh HIF2α. Hubungan SDF1/CXCR4 dan Alde-rendah EPCs masih perlu diteliti lebih lanjut.]]>
<![CDATA[Therapeutic Effect of Avocatin B in Avocados Toward Acute Myeloid Leukemia ]]>
<![CDATA[Dias Rima Sutiono]]>;
<![CDATA[Anthony Ryan Pantoni]]>
<![CDATA[ Cermin Dunia Kedokteran Vol. 45 No. 11 (2018): Neurologi ]]>
Publisher : <![CDATA[PT Kalbe Farma Tbk. ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.55175/cdk.v45i11.695
<![CDATA[Acute myeloid leukemia is the abnormal division of immature myeloid precursor cells in the bone marrow affecting mostly older people. Till date, there are no potent treatments due to the fact that it cannot target leukemic stem cells which are responsible for relapse and initiation of leukemia. Current treatments can also pose side effects that might to be too harsh for older people. Avocatin B is a lipid derived from avocado that can be a novel potent drug to replace or go along with the current therapies. Avocatin B is able to induce leukemic cell death and their stem cells while leaving normal cells unharmed. Their mechanisms of actions include inhibiting fatty acid oxidation which causes reactive oxygen species mediated apoptosis and lipotoxicity. Their selectivity towards leukemic cells over normal cells are due to the fact that they are able to target leukemic mitochondria which are different from the normal cells’ mitochondria in terms of their metabolic pathways. Leukemia myeloid akut merupakan sel precursor myeloid dalam sumsum tulang dewasa yang abnormal. Hingga saat ini, belum ada terapi yang tepat untuk leukemia myeloid akut. Avocatin B adalah lipid yang berasal dari alpukat, dapat menjadi obat baru atau digabungkan dengan terapi saat ini. Avocatin B mampu menginduksi kematian sel leukemia dan sel induknya. Mekanisme Avocation B meliputi penghambatan oksidasi asam lemak yang menyebabkan oksigen reaktif memediasi apoptosis dan lipotoksisitas. Selektivitas avocatin B terhadap sel-sel leukemia karena dapat menarget mitokondria penderita leukemia yang berbeda jalur metabolisme dari mitokondria sel-sel normal.]]>
