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Dias Rima Sutiono
Indonesia International Institute for Life Sciences (i3L), Jakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments Dias Rima Sutiono; Fransiska Adeline
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.727

Abstract

The Hutchinson-Gilford Progeria syndrome (HGPS) is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting the skin, musculoskeletal system and blood vessels, also other features supporting aging processes. This disease affects 1 in 4 - 8 million newborns all over the world without any race and gender preferences. The clinical features of HGPS usually appear at the age of two and will be discovered through clinical diagnosis. It then will be followed by health problems like coronary atherosclerosis that can be life-threatening. The life-span is usually 14,6 years. This review will discuss some emerging potential treatment such as FTI (Farnesyltransferase inhibitors). Sindrom Hutchinson-Gilford Progeria adalah penyakit genetik langka berupa penuaan lebih cepat pada usia anak-anak ditandai beberapa manifestasi di antaranya kulit, sistem muskuloskeletal dan pembuluh darah, serta hal lain sesuai proses penuaan. Penyakit ini terjadi pada 1 di antara 4-8 juta bayi baru lahir di seluruh dunia tanpa preferensi ras dan gender. Gambaran klinis HGPS biasanya muncul di usia dua tahun, diikuti masalah kesehatan seperti aterosklerosis pembuluh darah koroner yang dapat mengancam jiwa. Rentang hidup pasien HGPS biasanya 14,6 tahun. Ulasan ini mengenai beberapa pengobatan potensial seperti FTI (inhibitor Farnesyltransferase).
Significance of Lewy Body Formation in Development of Parkinson’s Disease Shivanki Sahay; Dias Rima Sutiono
Cermin Dunia Kedokteran Vol. 45 No. 8 (2018): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i8.736

Abstract

Parkinson’s disease is a serious neurodegenerative disease characterized by depletion of neurons in the substantia nigra of the basal ganglia. These dying out neurons are found to contain traces of Lewy bodies, an abnormal protein filament of alpha-synuclein and that otherwise play an important role in the nervous system, especially at synapses.   Penyakit Parkinson merupakan penyakit neurodegeneratif serius ditandai dengan deplesi neuron di substansia nigra ganglia basalis. Neuron ditemukan mengandung jejak Lewy Bodies, yang merupakan filamen protein abnormal alpha-synuclein
Zika Virus and its Threads to Microcephaly Dias Rima Sutiono; Cintya Pradnya Pratita
Cermin Dunia Kedokteran Vol 45 No 7 (2018): Onkologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.774

Abstract

The infection of ZIKV is through transplacental transmission. Polymerase Chain Reaction (PCR) detected the strains of ZIKV inside amniotic fluid only when in other fluids : serum and urine, revealed negative results. Microcephaly with numerous calcifications were discovered in the fetus of all cases. Ventriculomegaly and CNS structures anomalies were also discovered, though some structures such as subcortical nuclei of the brain and ascending dorsal columns of the spinal tract were well preserved.   Infeksi ZIKV melalui transmisi plasenta. Galur ZIKV dalam cairan ketuban dapat dideteksi menggunakan Polymerase Chain Reaction (PCR) hanya jika cairan lainnya, serum dan urin, negatif. Mikrosefali dengan kalsifikasi di semua kasus; lingkar kepala janin di bawah persentil kedua (34 cm). Ventrikulomegali dan struktur system saraf pusat abnormal, meskipun beberapa struktur seperti inti subkortikal otak dan jaras dorsalis medulla spinalis masih baik.
Hypnosis for Pain Alleviation: Placebo or Nocebo? Dias Rima Sutiono; Jeremy Putra Gunawan; Astrella Devina; Wibi Sindjaja; Jesslyn Pavita
Cermin Dunia Kedokteran Vol 46 No 2 (2019): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i2.514

Abstract

The use of hypnosis to alleviate pain had started to gain recognition. In the assessed papers, application of hypnosis has included childbirth, surgeries, and chronic pain. In childbirth, the use of self-hypnosis can reduce the use of analgesics from 78% to 45% of cases. The satisfaction of hypnobirthing—birth using hypnosis—reaches 96%. Hypnosis can decrease the use of anesthesia drugs during surgery, promotes healing, decreases bleeding and hospital stay. Hypnosis can alleviate pain and reduce the use of over the counter painkillers; also showed benefits for non-cardiac chest pain relief while also reduces medication. Currently, hypnosis had been the most prominent application for labour pain relief. There is a demand for more studies of bioinformatics and neuroscience. Banyak pustaka menjelaskan penerapan hypnosis pada proses melahirkan, operasi, dan nyeri kronis. Pada proses melahirkan, self-hypnosis dapat mengurangi penggunaan analgesic dari 78% menjadi 45% kasus. Kepuasan hypnobirthing – kelahiran menggunakan hypnosis - mencapai 96%. Hipnosis dapat mengurangi penggunaan obat anestesi, mempromosikan penyembuhan, mengurangi perdarahan dan lama rawat di rumahsakit pascaoperasi. Hipnosis bisa mengurangi penggunaan obat penghilang nyeri; juga menunjukkan manfaat untuk penderita nyeri dada non-jantung selain mengurangi konsumsi obat. Saat ini, aplikasi hipnosis yang paling menonjol untuk nyeri persalinan. Diperlukan studi bioinformatika dan neuroscience lebih lanjut.
Aldehyde-Low Endothelial Progenitor Cells in Ischemic Wound Repair, Regulated by SDF1/CXCR4 Dias Rima Sutiono; Candra Louis
Cermin Dunia Kedokteran Vol 45 No 12 (2018): Interna
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i12.689

Abstract

The incidence rate of both ischemic heart disease and ischemic stroke over the past decade has become a concern in the respect of global mortality rate. Ischemia is a condition of oxygen deprivation in the specific tissue which leads to loss of organ function. Regenerative medicine by using the endothelial progenitor cells (EPCs) show a great potential, especially the Alde-Low EPCs. The Alde-Low EPCs are regulated mainly by the chemo-attractant proteins of SDF1/CXCR4 which responsible for the cell migration and is regulated by the HIF2α. Further investigation and research on the correlation of SDF1/CXCR4 and the Alde-Low EPCs are needed. Peningkatan kejadian dan kematian akibat penyakit jantung iskemik dan stroke iskemik secara global pada beberapa dasawarsa telah menjadi perhatian. Upaya regenerasi menggunakan sel progenitor endothelial (EPCs) memperlihatkan potensi sangat tinggi, khususnya Alde-rendah EPCs. Alde-rendah EPCs diregulasi oleh protein kemoatraktan dari SDF1/CXCR4 yang bertanggung jawab untuk migrasi sel dan diregulasikan oleh HIF2α. Hubungan SDF1/CXCR4 dan Alde-rendah EPCs masih perlu diteliti lebih lanjut.
Therapeutic Effect of Avocatin B in Avocados Toward Acute Myeloid Leukemia Dias Rima Sutiono; Anthony Ryan Pantoni
Cermin Dunia Kedokteran Vol 45 No 11 (2018): Neurologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i11.695

Abstract

Acute myeloid leukemia is the abnormal division of immature myeloid precursor cells in the bone marrow affecting mostly older people. Till date, there are no potent treatments due to the fact that it cannot target leukemic stem cells which are responsible for relapse and initiation of leukemia. Current treatments can also pose side effects that might to be too harsh for older people. Avocatin B is a lipid derived from avocado that can be a novel potent drug to replace or go along with the current therapies. Avocatin B is able to induce leukemic cell death and their stem cells while leaving normal cells unharmed. Their mechanisms of actions include inhibiting fatty acid oxidation which causes reactive oxygen species mediated apoptosis and lipotoxicity. Their selectivity towards leukemic cells over normal cells are due to the fact that they are able to target leukemic mitochondria which are different from the normal cells’ mitochondria in terms of their metabolic pathways. Leukemia myeloid akut merupakan sel precursor myeloid dalam sumsum tulang dewasa yang abnormal. Hingga saat ini, belum ada terapi yang tepat untuk leukemia myeloid akut. Avocatin B adalah lipid yang berasal dari alpukat, dapat menjadi obat baru atau digabungkan dengan terapi saat ini. Avocatin B mampu menginduksi kematian sel leukemia dan sel induknya. Mekanisme Avocation B meliputi penghambatan oksidasi asam lemak yang menyebabkan oksigen reaktif memediasi apoptosis dan lipotoksisitas. Selektivitas avocatin B terhadap sel-sel leukemia karena dapat menarget mitokondria penderita leukemia yang berbeda jalur metabolisme dari mitokondria sel-sel normal.
Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments Dias Rima Sutiono; Fransiska Adeline
Cermin Dunia Kedokteran Vol 45 No 9 (2018): Infeksi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i9.727

Abstract

The Hutchinson-Gilford Progeria syndrome (HGPS) is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting the skin, musculoskeletal system and blood vessels, also other features supporting aging processes. This disease affects 1 in 4 - 8 million newborns all over the world without any race and gender preferences. The clinical features of HGPS usually appear at the age of two and will be discovered through clinical diagnosis. It then will be followed by health problems like coronary atherosclerosis that can be life-threatening. The life-span is usually 14,6 years. This review will discuss some emerging potential treatment such as FTI (Farnesyltransferase inhibitors). Sindrom Hutchinson-Gilford Progeria adalah penyakit genetik langka berupa penuaan lebih cepat pada usia anak-anak ditandai beberapa manifestasi di antaranya kulit, sistem muskuloskeletal dan pembuluh darah, serta hal lain sesuai proses penuaan. Penyakit ini terjadi pada 1 di antara 4-8 juta bayi baru lahir di seluruh dunia tanpa preferensi ras dan gender. Gambaran klinis HGPS biasanya muncul di usia dua tahun, diikuti masalah kesehatan seperti aterosklerosis pembuluh darah koroner yang dapat mengancam jiwa. Rentang hidup pasien HGPS biasanya 14,6 tahun. Ulasan ini mengenai beberapa pengobatan potensial seperti FTI (inhibitor Farnesyltransferase).
Significance of Lewy Body Formation in Development of Parkinson’s Disease Shivanki Sahay; Dias Rima Sutiono
Cermin Dunia Kedokteran Vol 45 No 8 (2018): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i8.736

Abstract

Parkinson’s disease is a serious neurodegenerative disease characterized by depletion of neurons in the substantia nigra of the basal ganglia. These dying out neurons are found to contain traces of Lewy bodies, an abnormal protein filament of alpha-synuclein and that otherwise play an important role in the nervous system, especially at synapses.   Penyakit Parkinson merupakan penyakit neurodegeneratif serius ditandai dengan deplesi neuron di substansia nigra ganglia basalis. Neuron ditemukan mengandung jejak Lewy Bodies, yang merupakan filamen protein abnormal alpha-synuclein
Zika Virus and its Threads to Microcephaly Dias Rima Sutiono; Cintya Pradnya Pratita
Cermin Dunia Kedokteran Vol 45 No 7 (2018): Onkologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.774

Abstract

The infection of ZIKV is through transplacental transmission. Polymerase Chain Reaction (PCR) detected the strains of ZIKV inside amniotic fluid only when in other fluids : serum and urine, revealed negative results. Microcephaly with numerous calcifications were discovered in the fetus of all cases. Ventriculomegaly and CNS structures anomalies were also discovered, though some structures such as subcortical nuclei of the brain and ascending dorsal columns of the spinal tract were well preserved.   Infeksi ZIKV melalui transmisi plasenta. Galur ZIKV dalam cairan ketuban dapat dideteksi menggunakan Polymerase Chain Reaction (PCR) hanya jika cairan lainnya, serum dan urin, negatif. Mikrosefali dengan kalsifikasi di semua kasus; lingkar kepala janin di bawah persentil kedua (34 cm). Ventrikulomegali dan struktur system saraf pusat abnormal, meskipun beberapa struktur seperti inti subkortikal otak dan jaras dorsalis medulla spinalis masih baik.
Co-Authors Anthony Ryan Pantoni Astrella Devina Candra Louis Cintya Pradnya Pratita Fransiska Adeline Ibdati Malika Jeremy Putra Gunawan Jesslyn Pavita Nadita Putri Almira Samirah - Sheila Lestari Shivanki Sahay Siti Aisyah Wibi Sindjaja