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Synthesis and Characterization of Magnetic Molecularly Imprinted Polymers Targeting Capsaicin Amri, Ahmad Mukhlasul; Azis, Muhammad Yudhistira; Zulfikar, Muhammad Ali
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40808

A novel magnetic molecularly imprinted polymers (MMIPs) was developed for the adsorption of capsaicin, a key component of capsaicinoids widely used in food additives and topical pharmaceuticals. Excessive use of capsaicin can lead to respiratory, skin, and oral disorders, necessitating effective monitoring methods. This study aimed to synthesize MMIPs and magnetic molecularly non imprinted polymers (MNIPs) using 4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker, combined with an initiator in a 1:4:20 molar ratio. Magnetite nanoparticles (Fe3O4) were incorporated to facilitate magnetic separation. Characterization via particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the successful synthesis of Fe3O4 nanoparticles, MNIPs, and MMIPs. PSA analysis for Fe3O4 nanoparticles showed an average size of 140.2 nm with a polydispersity index (PI) of 0.313, MMIPs showed an average particle size of 746.6 nm and a PI value of 0.397. FTIR spectra revealed characteristic absorption bands at 3429 cm−1 (O-H), 2958 cm−1 (C-H), 1732 cm−1 (C=O), 1155 cm−1 (C-O), and 580 cm−1(Fe-O), indicating successful Fe3O4 modification. SEM-EDS analysis showed non-spherical morphology due to bulk polymerization. TEM image results showed Fe₃O₄ nanoparticles were successfully coated with a molecularly imprinted polymer (MIP). The developed MMIPs effectively have a robust synthesis method and thorough analysis, laying the groundwork for future applications.

PEGEMBANGAN DAN VALIDASI METODE HEPARIN ATAU ENOKSAPARIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI PASANGAN ION Astuti, Engrid Juni; Hidayati, Ika Ratna; Ibrahim, Slamet; Zulfikar, Muhammad Ali
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24659

One of the drugs used to treats and prevents COVID-19 thromboembolic problems is heparin or enoxaparin sodium. Heparin and enoxaparin have the side effect of bleeding when used, so monitoring of therapy is necessary. This present study aims to validate an ion pair high-performance liquid chromatography (HPLC) condition to analyse the adsorption of heparin or enoxaparin at molecularly imprinted polymer (MIP) after synthesis. The chromatographic system consists of a C8 column with a Diode Array Detector (DAD). The optimal chromatographic condition was obtained using mobile phase A (300mM NaCl + 10mM tetra n-butyl ammonium hydroxide) and mobile phase B (acetonitrile) under gradient elution, and 100 µl injection volume. The heparin or enox was detected at 231 nm, generating symmetrical peaks and good separation in 4.1 minutes after injection. The method indicated good selectivity with a resolution of 3.49 for heparin and 3.74 for enox. A linear detector response with R2 of 0.9965 and 0.9994 for heparin and enox. The method yields good precision and good accuracy. The proposed method has met the method validation requirements for adsorption heparin or enox analysis before using validation in biological samples.

Kinetic Models for the Sorption of Methylene Blue From Aqueous Solution by Molecularly Imprinted Polymers Zulfikar, Muhammad Ali; Setiyanto, Henry
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2016: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.2356

The research examined the effect of concentration on Methylene Blue (MB) adsorption by using Molecularly Imprinted Polymer (MIP). The experimental data were analyzed by using pseudo-firstkinetic, pseudo-second-kinetic and particle diffusion models. From the experiment, it could be seen that the MB adsorption using MIP decreased with increasing dye initial concentration. The adsorption kinetic data of MB on MIP was well described by a first-second-order model, with the kinetic constants in the range of 0.037- 0.067 min-1. In addition, the results also indicated that the intra-particle diffusion was not the rate limiting step in the MB adsorption process.

Synthesis and Characterization of Magnetic Molecularly Imprinted Polymers Targeting Capsaicin Amri, Ahmad Mukhlasul; Azis, Muhammad Yudhistira; Zulfikar, Muhammad Ali
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40808

A novel magnetic molecularly imprinted polymers (MMIPs) was developed for the adsorption of capsaicin, a key component of capsaicinoids widely used in food additives and topical pharmaceuticals. Excessive use of capsaicin can lead to respiratory, skin, and oral disorders, necessitating effective monitoring methods. This study aimed to synthesize MMIPs and magnetic molecularly non imprinted polymers (MNIPs) using 4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker, combined with an initiator in a 1:4:20 molar ratio. Magnetite nanoparticles (Fe3O4) were incorporated to facilitate magnetic separation. Characterization via particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the successful synthesis of Fe3O4 nanoparticles, MNIPs, and MMIPs. PSA analysis for Fe3O4 nanoparticles showed an average size of 140.2 nm with a polydispersity index (PI) of 0.313, MMIPs showed an average particle size of 746.6 nm and a PI value of 0.397. FTIR spectra revealed characteristic absorption bands at 3429 cm−1 (O-H), 2958 cm−1 (C-H), 1732 cm−1 (C=O), 1155 cm−1 (C-O), and 580 cm−1(Fe-O), indicating successful Fe3O4 modification. SEM-EDS analysis showed non-spherical morphology due to bulk polymerization. TEM image results showed Fe₃O₄ nanoparticles were successfully coated with a molecularly imprinted polymer (MIP). The developed MMIPs effectively have a robust synthesis method and thorough analysis, laying the groundwork for future applications.

DEGRADASI LIMBAH AMOKSISILIN DENGAN OKSIDASI ELEKTROKIMIA YANG DIMEDIASI KOBAL III MENGGUNAKAN ELEKTRODA PLATINA, PLATINA-KOBAL HIDROKSIDA DAN PLATINA-KOBAL Herlina, Herlina; Sirumapea, Lasmaryna; Zulfikar, Muhammad Ali; Buchari, Buchari
Analit : Analytical and Environmental Chemistry Vol. 8, No. 01 April (2023) Analit: Analytical and Environmental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/aec.v8i1.2023.p88-99

Degradasi amoksisilin (AMX) telah dipelajari melalui proses oksidasi elektrokimia di sel ruah menggunakan elektroda platina dan elektroda platina- dimodifikasi kobal sebagai anoda dan platina sebagai katoda. Proses degradasi AMX diselidiki dengan pengukuran HPLC. Oksidasi elektrokimia AMX menggunakan sel ruah skala laboratorium dengan penerapan tegangan 6 V, arus 1200 mA, dan volume larutan yang didegradasi 250 mL untuk konsentrasi awal AMX 1000 µM memberikan hasil yang cukup memuaskan, terutama untuk proses elektro-oksidasi sampel nyata limbah AMX menggunakan material anoda Platina-kobal dimediasi Co(III) dengan persen degradasi sebesar 99,03% selama 6 jam, anoda Platina-kobal(OH)2 sebesar 92,35% dan anoda Platina sebesar 76,91%. Ditemukan bahwa elektroda Platina-Kobal menunjukkan kemampuan mineralisasi yang baik dalam kondisi netral dalam larutan elektrolit Na2SO4 dengan penerapan tegangan oksidasi, waktu oksidasi dan variasi mediator. Kata Kunci: degradasi, amoksisilin, elektr okimia. oksidasi, platina

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