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Synthesis and Characterization of Magnetic Molecularly Imprinted Polymers Targeting Capsaicin Amri, Ahmad Mukhlasul; Azis, Muhammad Yudhistira; Zulfikar, Muhammad Ali
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40808

A novel magnetic molecularly imprinted polymers (MMIPs) was developed for the adsorption of capsaicin, a key component of capsaicinoids widely used in food additives and topical pharmaceuticals. Excessive use of capsaicin can lead to respiratory, skin, and oral disorders, necessitating effective monitoring methods. This study aimed to synthesize MMIPs and magnetic molecularly non imprinted polymers (MNIPs) using 4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker, combined with an initiator in a 1:4:20 molar ratio. Magnetite nanoparticles (Fe3O4) were incorporated to facilitate magnetic separation. Characterization via particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the successful synthesis of Fe3O4 nanoparticles, MNIPs, and MMIPs. PSA analysis for Fe3O4 nanoparticles showed an average size of 140.2 nm with a polydispersity index (PI) of 0.313, MMIPs showed an average particle size of 746.6 nm and a PI value of 0.397. FTIR spectra revealed characteristic absorption bands at 3429 cm−1 (O-H), 2958 cm−1 (C-H), 1732 cm−1 (C=O), 1155 cm−1 (C-O), and 580 cm−1(Fe-O), indicating successful Fe3O4 modification. SEM-EDS analysis showed non-spherical morphology due to bulk polymerization. TEM image results showed Fe₃O₄ nanoparticles were successfully coated with a molecularly imprinted polymer (MIP). The developed MMIPs effectively have a robust synthesis method and thorough analysis, laying the groundwork for future applications.

PEGEMBANGAN DAN VALIDASI METODE HEPARIN ATAU ENOKSAPARIN MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI PASANGAN ION Astuti, Engrid Juni; Hidayati, Ika Ratna; Ibrahim, Slamet; Zulfikar, Muhammad Ali
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24659

One of the drugs used to treats and prevents COVID-19 thromboembolic problems is heparin or enoxaparin sodium. Heparin and enoxaparin have the side effect of bleeding when used, so monitoring of therapy is necessary. This present study aims to validate an ion pair high-performance liquid chromatography (HPLC) condition to analyse the adsorption of heparin or enoxaparin at molecularly imprinted polymer (MIP) after synthesis. The chromatographic system consists of a C8 column with a Diode Array Detector (DAD). The optimal chromatographic condition was obtained using mobile phase A (300mM NaCl + 10mM tetra n-butyl ammonium hydroxide) and mobile phase B (acetonitrile) under gradient elution, and 100 µl injection volume. The heparin or enox was detected at 231 nm, generating symmetrical peaks and good separation in 4.1 minutes after injection. The method indicated good selectivity with a resolution of 3.49 for heparin and 3.74 for enox. A linear detector response with R2 of 0.9965 and 0.9994 for heparin and enox. The method yields good precision and good accuracy. The proposed method has met the method validation requirements for adsorption heparin or enox analysis before using validation in biological samples.

Kinetic Models for the Sorption of Methylene Blue From Aqueous Solution by Molecularly Imprinted Polymers Zulfikar, Muhammad Ali; Setiyanto, Henry
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2016: Proceeding ISETH (International Conference on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.2356

The research examined the effect of concentration on Methylene Blue (MB) adsorption by using Molecularly Imprinted Polymer (MIP). The experimental data were analyzed by using pseudo-firstkinetic, pseudo-second-kinetic and particle diffusion models. From the experiment, it could be seen that the MB adsorption using MIP decreased with increasing dye initial concentration. The adsorption kinetic data of MB on MIP was well described by a first-second-order model, with the kinetic constants in the range of 0.037- 0.067 min-1. In addition, the results also indicated that the intra-particle diffusion was not the rate limiting step in the MB adsorption process.

Synthesis and Characterization of Magnetic Molecularly Imprinted Polymers Targeting Capsaicin Amri, Ahmad Mukhlasul; Azis, Muhammad Yudhistira; Zulfikar, Muhammad Ali
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40808

A novel magnetic molecularly imprinted polymers (MMIPs) was developed for the adsorption of capsaicin, a key component of capsaicinoids widely used in food additives and topical pharmaceuticals. Excessive use of capsaicin can lead to respiratory, skin, and oral disorders, necessitating effective monitoring methods. This study aimed to synthesize MMIPs and magnetic molecularly non imprinted polymers (MNIPs) using 4-vinyl pyridine as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker, combined with an initiator in a 1:4:20 molar ratio. Magnetite nanoparticles (Fe3O4) were incorporated to facilitate magnetic separation. Characterization via particle size analyzer (PSA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the successful synthesis of Fe3O4 nanoparticles, MNIPs, and MMIPs. PSA analysis for Fe3O4 nanoparticles showed an average size of 140.2 nm with a polydispersity index (PI) of 0.313, MMIPs showed an average particle size of 746.6 nm and a PI value of 0.397. FTIR spectra revealed characteristic absorption bands at 3429 cm−1 (O-H), 2958 cm−1 (C-H), 1732 cm−1 (C=O), 1155 cm−1 (C-O), and 580 cm−1(Fe-O), indicating successful Fe3O4 modification. SEM-EDS analysis showed non-spherical morphology due to bulk polymerization. TEM image results showed Fe₃O₄ nanoparticles were successfully coated with a molecularly imprinted polymer (MIP). The developed MMIPs effectively have a robust synthesis method and thorough analysis, laying the groundwork for future applications.

Anthrone-based Dummy Molecularly Imprinted Polymer for the Selective Detection of Fluorene and Phenanthrene in Simulated River Water Pinandita, Aria; Handayani, Nurrahmi; Iqbal, Muhammad; Triadhi, Untung; Rusnadi, Rusnadi; Djajanti, Samitha Dewi; Amran, Muhammad Bachri; Zulfikar, Muhammad Ali
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

A dummy-template molecularly imprinted polymer (DMIP) was synthesized via precipitation polymerization using anthrone as a template analog for the selective analysis of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs), specifically fluorene and phenanthrene. Styrene, benzoyl peroxide, and ethylene glycol dimethacrylate were employed as the functional monomer, radical initiator, and crosslinking agent, respectively. The synthesized polymers were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and particle size analysis. The imprinting factors were 1.16 and 1.09 for fluorene and phenanthrene, respectively, indicating enhanced affinity of the imprinted sites. High-performance liquid chromatography analysis following DMIP-based solid-phase extraction yielded recoveries of 91.49% ± 3.87% for fluorene and 97.25% ± 2.85% for phenanthrene, demonstrating the DMIP’s potential as an efficient sorbent for selective extraction and quantification of low-molecular-weight PAHs in simulated river water.

Molecular Dynamics Simulation Study: Mechanism Of Cationic And Anionic Dyes Adsorption On Montmorillonite Mubarokah, Febriati Dian; Ledyastuti, Mia; Zulfikar, Muhammad Ali
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 10, No 3 (2025): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v10i3.100095

Discharging dye-containing wastewater can severely degrade water quality. Adsorption is widely studied because it is selective, effective, and relatively low cost. This work examines adsorption of a cationic dye, crystal violet (CV), and an anionic dye, congo red (CR), on montmorillonite clay (MMT) using molecular dynamics simulations in GROMACS. Molecular topologies were built with a combined ClayFF and CHARMM36 force field. Simulations used a 6 nm × 6 nm × 6 nm box filled with SPC/E water (spce.gro). After minimization and NVT and NPT equilibration, production runs were carried out for 50 ns (25,000,000 steps) with a 2 fs time step at 300 K and 1 bar. Single-dye and mixed-dye systems were compared to clarify adsorption mechanisms. In the single CV system, the best performance occurred at 20 CV molecules, giving 40% adsorption. Radial distribution analysis indicates that adsorption is dominated by van der Waals interactions between the negatively charged MMT surface and the CV quaternary ammonium site (-N+). In contrast, CR was not adsorbed in the single CR system because electrostatic repulsion prevents approach to the negatively charged clay. In mixed CV–CR systems, adsorption of both dyes increased, revealing synergistic behavior. CV enters the MMT interlayer and forms an organic phase, which then immobilizes CR through hydrophobic interactions, enabling CR adsorption despite its unfavorable electrostatics under realistic wastewater conditions.

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