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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Manajemen Pelayanan Kesehatan (The Indonesian Journal of Health Service Management) IJRETINA - International Journal of Retina Ophthalmologica Indonesiana
Firman Setya Wardhana
Department Of Ophthalmology, Faculty Of Medicine, Public Health, And Nursing, University Of Gadjah Mada, Yogyakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

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Kadar Plasma 25-Hydroxyvitamin-D (25-OHD) pada Pasien Age-related Macular Degeneration (AMD) Stadium Akhir di Yogyakarta: Studi Korelasi Supanji Supanji; Dewi Fathin Romdhoniyyah; Ayudha Bahana Ilham Perdamaian; Anindita Dianratri; Muhammad Bayu Sasongko; Angela Nurini Agni; Tri Wahyu Widayanti; Firman Setya Wardhana; Dian Caturini Sulistyaningrum; Mohammad Eko Prayogo; Masashi Kawaichi; Chio Oka
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 3, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss3.art3

Abstract

Background: Age-related Macular Degeneration (AMD) is a degenerative disease caused by multiple factors, including inflammation. This condition may lead to irreversible macular damage. Vitamin D has anti-inflammatory and immune-modulating qualities, therefore, is expected to protect against the development of AMD.Objective: This study aimed to evaluate the correlation between plasma 25-hydroxyvitamin D (plasma 25-OHD) levels and neovascular Age-Related Macular Degeneration (nAMD).Methods: This was a case-control study involving AMD and control subjects. All subjects underwent a standardized eye examination to check for eligibility by a retinal specialist. Blood samples were drawn for analysis using a DRG Elisa Kit to determine the plasma 25-OHD (Total). Plasma 25-OHD levels were categorized into deficiency (<12 ng/mL), insufficiency (12 - <20 ng/mL), adequate (20 – 50 ng/mL), and high (>50 ng/mL).Results: Total subjects were 39, which consisted of 20 AMD subjects and 19 controls. There were 17 male subjects (43.6%) and 22 female subjects (56.4%). The mean age for the case and control group was 69.35±7.04 and 68.26±6.83, respectively (p=0.612). Those in their 70s dominated the age distribution with a percentage of 56.41% of all participants. The mean plasma 25-OHD in the case group was 32.30±17.10 ng/mL, while the control group was 50.63±11.95 ng/mL (p=0.066). There was no significant association between AMD and plasma 25-OHD levels in all groups (p>0.05).Conclusion: Plasma 25-OHD levels did not correlate positively with nAMD in our study population.
Co-Authors Angela Nurini Agni Angela Nurini Agni Angela Nurini Agni Anggun Desi Wulandari Anindita Dianratri Ayudha Bahana Ilham Perdamaian Chio Oka Dewi Fathin Romdhoniyyah Dhimas Ali Firman Dhimas Hari Sakti Dian Caturini Sulistyaningrum Dwima Faiqa Nafisha Indra Tri Mahayana Irene Titin Darajati Irwan Endrayanto Aluicius Masashi Kawaichi Mohammad Eko Prayogo Muhammad Bayu Sasongko Novika Handayani Supanji Supanji Supanji Supanji Supanji Supanji Tiara Putri Utami Tri Wahyu Widayanti Tri Wahyu Widayanti Tri Wahyu Widayanti