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Widya Artini
Departement of Ophthalmology, Universitas Indonesia
Health Professions Medicine & Pharmacology Public Health

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Diagnostic Performance of Macular Ganglion Cell/Inner Plexiform Layer Thickness to Discriminate Normal Eye from Eye with Early Glaucoma Using Cirrus Spectral-Domain Optical Coherence Tomography Widya Artini; Baltazar Bimo Bisara
Majalah Oftalmologi Indonesia Vol 43 No 1 (2017): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v43i1.132

Abstract

Background: Glaucoma is a progressive optic neuropathy characterized by a progressive loss of retinal ganglion cells (RGC). In glaucomatous optic neuropathy, structural optic nerve changes may occur before detectable functional loss, which can be diagnosed early by detecting loss of RGC. This review was conducted to see the diagnostic performance of macular ganglion cell/inner plexiform layer (GC-IPL) thickness parameters to discriminate normal eye from early glaucoma eye using Cirrus Spectral-domain OCT compared to peri-papilarry Retinal Nerve Fiber Layer (RNFL) thickness parameters. Methods: Literature search was conducted from MEDLINE database using Pubmed, Clinical Key, and ScienceDirect. No publication date was set, and only articles published in English were included. Reference list from the included studies were also checked for potentially relevant articles. Results: Twenty articles were found related to search term. Seven articles met the inclusion criteria. Fourteen others were excluded. All studies revealed significant thinner GC-IPL and RNFL average thickness in glaucoma patients compared to normal patients. GC-IPL Average was inferior to GC-IPL Minimum and RNFL inferior in determining normal eye from early glaucomatous eyes. Studies evaluating the diagnostic performance of Ganglion Cells Complex (GCC) thickness also found low sensitivity values, ranging between 61.0% and 78.6% for average GCC. Conclusion: Diagnostic performance of GC-IPL is comparable to RNFL parameters measurement in detecting early glaucoma eyes. Best performance in detecting early glaucoma were showed by GC-IPL minimum and RNFL inferior.
The effect of mirtogenol towards the changes in retinal nerve fiber layer thickness and visual field in primary open angle glaucoma Astriviani Widyakusuma; Widya Artini; Virna Dwi Oktariana; Joedo Prihartono
Majalah Oftalmologi Indonesia Vol 43 No 1 (2017): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v43i1.134

Abstract

Objective: To evaluate the effect of Mirtogenol towards the changes in retinal nerve fiber layer (RNFL) thickness and visual field in patients with primary open angle glaucoma (POAG) with controlled IOP. Methods: This is a prospective, double blind, randomized study. Forty one POAG patients with IOP ≤ 18 mmHg were randomly assigned to receive either Mirtogenol or placebo. Changes in RNFL thickness and mean deviation of visual fields were evaluated before the treatment, as well as 4 weeks and 8 weeks after the treatment. Patients were asked for any side effects during the treatment period. Result: The average RNFL thickness in the Mirtogenol group decreased -0.70±1.63 μm from 87.29±19.39 μm before the treatment to 86.58±19.43 μm after 8 weeks of treatment, however the change was not significant (p=0.121). The average RNFL thickness in the placebo group decreased -1.74±1.79 μm from 97.14±17.19 μm before the treatment to 95.40±18.56 μm after 8 weeks of treatment, the change was statistically significant (p< 0.001). The average MD of visual field in the Mirtogenol group increased 0.542±1.93 dB after 8 weeks of treatment while the MD of visual field in the placebo group decreased -0.083±1.36 dB after 8 weeks of treatment. Hoewever the changes in MD of visual field was not significant (p>0.05). No side effect was found throughout the study. Conclusion: Mirtogenol seemed to maintain retinal nerve fiber layer thickness and increased mean deviation of visual fields.
Co-Authors Astriviani Widyakusuma Baltazar Bimo Bisara Joedo Prihartono Virna Dwi Oktariana