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Mirhansyah Ardana
Laboratorium Penelitian Dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulasi Sediaan Mouthwash Ekstrak Daun Sirih Hitam (Piper sp.) Terhadap Streptococcus mutans dan Candida albicans: Mouthwash Preparation Formulation of Black Betel Leaf Extract (Piper sp.) Against Streptococcus mutans and Candida albicans Deschania Noor Qhorina; Fajar Prasetya; Mirhansyah Ardana
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.578 KB) | DOI: 10.25026/mpc.v14i1.550

Abstract

Black betel (Piper sp.) contains compounds that function as antimicrobials, namely tannins, phenolic compounds, saponins, flavonoids, alkaloids, and steroids that can be used as active ingredients for making mouthwash. The purpose of this study was to determine the effective mouthwash formulation used as an antimicrobial. Antimicrobial testing method using well diffusion method with a reserve of 6 mm. Black betel leaf extract was dissolved with a variation of the concentration of glycerin 1:4; 1:8 and 1:12 and tested on Streptococcus mutans and Candida albicans bacteria, then tested for stability of the preparations, including organoleptic, pH and viscosity. The results obtained from various solvents were glycerin as the most stable solvent compared to 96% ethanol, tween 80 and aquades. The results obtained from the antimicrobial test with ANOVA analysis were for Streptococcus mutans bacteria p=0.004 (p<0.05) which means the p-value was significant between concentration variations and bacteria and for the fungus Candida albicans p=0.295 (p>0.05) which meant the p-value was not significant difference between concentration variations and fungi. The results of the evaluation test for the stability of the preparation, namely the organoleptic data, pH and viscosity at a temperature of 25ºC were relatively stable.
Kajian Literatur: Aktivitas Antioksidan Ekstrak Tanaman Cempedak (Artocarpus champeden Spreng): Literature Review: Antioxidant Activity of Cempedak Plant Extract (Artocarpus champeden Spreng) Aulia Alfath Rahmawati; Mirhansyah Ardana; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.211 KB) | DOI: 10.25026/mpc.v14i1.594

Abstract

Antioxidants are compounds that can counteract free radicals. One of the plants that have antioxidant activity is cempedak, because cempedak contains flavonoids compounds. This writing aims to determine the antioxidant activity of cempedak plants based on a review of several literatures. The method of writing a literature review uses a journal search from Google Scholar. Based on the literature review that has been carried out, the leaves and bark of cempedak have antioxidant activity. Based on the literature review of antioxidant activity of cempedak, methanol extract of stem bark had antioxidant activity of 100,26 ppm, leaf methanol extract 8,88 ppm, leaf ethanol extract 52,7706 ppm, leaf ethyl acetate fraction 4,282 ppm. The part of the cempedak plant that has the highest antioxidant activity is found in the leaves with the ethyl acetate fraction which shows an IC50 value of 4,282 ppm. Based on the IC50 value obtained, the ethyl acetate fraction of cempedak leaves has a very strong antioxidant activity because the IC50 is below 50 ppm.
Co-Authors Aulia Alfath Rahmawati Deschania Noor Qhorina Fajar Prasetya Yurika Sastyarina