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All Journal Jambura Journal of Health Sciences and Research Journal On Teacher Education (Jote) Proceeding of Mulawarman Pharmaceuticals Conferences

Yurika Sastyarina

Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295738

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Standarisasi Ekstrak Umbi Bawang Tiwai (Eleutherine americana (Aubl.) Merr.) Asal Kalimantan Timur Aditya Fridayanti; Yurika Sastyarina; Herman Herman; Agung Rahmadani; Ganjar Firmansyah; Tri Woro Widyanti; Yuspian Nur; Hadi Kuncoro; Enggar Wijayanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Telah dilakukan standarisasi pada ekstrak etanol umbi bawang tiwai (Eleutherine americana (Aubl.). Merr). Hasil pengujian parameter spesifik menunjukkan organoleptik ekstrak kental, berwarna merah, tidak berbau dan memiliki rasa sedikit pahit, dengan kandungan senyawa larut air 25,36 ± 1,61 (%) dan senyawa larut etanol 11,52±1,87 (%) serta hasil kandungan senyawa marker ekstrak 0,002/g. Hasil pengujian parameter non spesifik ekstrak etanol 96% umbi bawang tiwai menunjukkan kadar abu total 0,90±0,35 (%), kadar abu tidak larut asam 0,78±0,25 (%), bobot jenis 0,9437±0,0012, kadar air 5,28±0,14%, sisa pelarut 1,019345±0,0001626% dan kadar fenol total 163,43 ppm. Pada ekstrak terdapat cemaran bakteri 3,5 x 104 koloni/gram dan cemaran kapang khamir sejumlah 3,0 x 103 koloni/gram. Pengujian cemaran logam berat diperoleh kadar timbal 0,0105 mg/mL, kadmium 0,0318 mg/L dan arsen 0,0412 mg/L. Pengujian residu pestisida negatif pada golongan klorin, organo fosfat dan karbamat. Hasil penelitian menunjukkan bahwa ekstrak memenuhi persyaratan umum obat yang dibuat oleh bahan alam

Uji Aktivitas Antioksidan Kombinasi Ekstrak Umbi Bawang Tiwai (Eleutherine bulbosa (Mill) Urb) dan Rimpang Kunyit(Curcuma domestica Val.) Yoni Miftahun Nafsiyah Agustin; Lisna Meylina; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Bawang tiwai (Eleutherine bulbosa (Mill) Urb)a plant that originated from Kalimantan. This plant is traditionally used as a medicinal plant in the community. Bawang tiwai have bioactive compounds such as alkaloids, flavonoids, saponins which act as antioxidants. In addition bawang tiwai, turmeric (Curcuma domestica Val.)is a traditional medicinal plant used for seasoning and is a medicinal plant as antimicrobial, antioxidant, anti-tumor and anti-inflammatory. The aim of the research is to measure the antioxidant activity of the combination of extracts of bawang tiwai(Eleutherine bulbosa (Mill) Urb)and Turmeric (Curcuma domestica Val.). Antioxidant activity test used the DPPH (1,1-Diphenyl-2-picryl Hidrazil) measured absorption at a wavelength of 517 nm. Antioxidant activity was assessed based on% inhibition (IC50) which is the concentration of the sample solution is needed to reduce free radicals by 50%. The results obtained by measuring the antioxidant activity fromcombination extracts of IC50 was 185,118 ppm respectively.

Isolasi Bakteri Termofilik dari Tanah Hutan Mangrove Fidhia Rara Lande; Wahyu Widayat; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Mangrove forest soil is a habitat and source of diversity of microorganisms, including thermophilic bacteria. The utilization of thermophilic bacteria has been carried out in the pharmaceutical field, especially as a source of raw materials for pharmaceutical products. This study aims to provide an overview of the population of thermophilic bacteria found in mangrove forest soils. Soil samples were obtained by random stratification with a depth of 5-10 cm at 9 points from 3 strata. The isolation media used were Starch Casein Agar (SCA), and the groups of bacteria determined by using the Gram staining method. The selected thermophilic bacteria from mangrove forest soil totaling 64 isolates consisted of Gram-negative that divides into 20 bacilli, 9 cocci, 6 vibrios, and Gram-positive consisted of 26 bacilli, 3 cocci. The highest population of thermophilic bacteria from mangrove forest soils was Gram-negative as many as 35 isolates.

Pengaruh Berbagai Metode Ekstraksi dari Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana Merr) terhadap Rendemen Ekstrak dan Profil Kromatografi Lapis Tipis Ayida Mawarda; Erwin Samsul; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The bulb of Eleutherine americana Merr is a typical Kalimantan plant that has many medicinal properties. Many studies have been carried out with various extraction methods used to determine the compounds contained in the bulb of Eleutherine americana Merr. This study aims to determine the effect of the method and the extraction time on the yield value and thin layer chromatography profile (TLC) of the bulb of Eleutherine americana Merr extract. The extraction method uses 96% ethanol solvent using the maceration method for 2 weeks and ultrasonic bath method with time variables of 10, 20 and 30 minutes. The yield of maceration extract was 12% and the ultrasonic bath method was 12.5%, 17.5%, and 15% (10, 20, 30 minutes). In the TLC test there were no differences in the spot patterns of the two extraction methods. So it can be concluded that the extraction method affects the yield of extract but does not affect the extract compound content seen from the TLC spot pattern.

Optimasi Formula Spray Gel Ekstrak Bawang Tiwai (Eleutherine americana (Aubl) Merr) Maulidya Maulidya; Fika Aryati; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The ethanolic extract from the bulb of Eleutherine americana has the potential for anti-inflammatory activity to be developed into a preparation that is a practical spray gel to use. The aim of this study is to made a spray gel containing ethanolic extract from the bulb of Eleutherine americana. Spray gel preparation was prepared by varying the concentration of Carbopol as a gelling agent with a concentration of F1 (0.4%), F2 (0.6%), and F3 (0.8%) with active substances and evaluated physical stability. Data from the results of physical stability testing in statistical analysis. Organoleptic test results and homogenity of ethanolic extract from the bulb of Eleutherine americana spray gel from all formulas showed stable, pH was in the range of 5.2-6.1 and Viscosity in formulas 1, 2, and 3 were respectively 0.65-1323 (Pa.s ) this condition is still within the range of viscosity of spray gel formulation, and have a spread pattern. While the formula 2 and 3, the viscosity is not eligible.

Optimasi Polivinilalkohol (PVA) Sebagai Basis Sediaan Gel Antijerawat Nur Aprilianti; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The gel is one of the preparations that are considered suitable for skin conditions with excessive sebaceous gland function. Polyvinylalcohol (PVA) is one of the gelling agents that can from a layer or film that is very strong and plastic to give good contact between the drug and the skin. This study aims to find the best concentration of polyvinylalcohol (PVA) as a gel base. Each formula was made using four variations of polyvinylalcohol (PVA) concentrations of 6%, 8%, 10%, and 12% and tested the physical properties that include organoleptic test, pH, homogeneity, spreadability, and viscosity. The results showed that the optimum of base formula contains a concentration of polyvinylalcohol (PVA) base of 6% and 8%.

Aktivitas Ekstrak Etanol Umbi Bawang Tiwai (Eleutherine americana (Aubl.) Merr) terhadap Kelarutan Kalsium Batu Ginjal secara In Vitro Triani Yastuti Kuling; Jaka Fadraersada; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kidney stones are a disease that occurs due to the deposition of compounds that are difficult to dissolve because the body lacks fluids. Bawang Tiwai (Eleutherine americana (Aubl.) Merr) is an endemic Dayak plant in Kalimantan which has been traditionally used as traditional medicine dayak’s people. One of the active components is flavanoid which can dissolve kidney stones. This study aims to determine the concentration activity of the bawang tiwai roots extract to dissolve kidney stone calcium. The extract was made by maceration method using ethanol 96%. The extraction activity testing used 5 treatments namely 1 ppm, 2 ppm, 3 ppm, negative control (distilled water) and positive control (elixir stone). Kidney stones were then added as much as 10 mg to each treatment. After the addition of kidney stones in each treatment incubation for 3 hours at 37 ?. Calcium solubility activity was seen by using a UV-Visible spectrophotometer by measuring the absorbance value of each test concentration. The results showed that the 3 ppm concentration was the optimal concentration in dissolving kidney stone calcium in vitro.

Karakteristik Rumput Banto (Leersia hexandra Sw.) Berdasarkan Makroskopik dan Mikroskopik Wa Ode Rungaya Ningsih Komala; Nur Mita; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Banto (Leersia hexandra Sw.) is a weed that is often used as animal feed, which is used to remove toxins in the body. The research to study the characteristics of Banto macroscopically and microscopically. A macroscopic test were carried out directly on the physical properties of Banto. Then a microscopic test of Bantos powder simplicia was conducted using a microscope. The result of the macroscopic examination of Banto show that Banto has smooth stem segments, roots on the stem segments, height can reach 1 m, leaf width reaches 0,4 cm-1 cm, leaf length is 5 cm-23 cm, the sides are rough and have sharp edges. For the results of the microscopic examination of fresh grass at 40× magnification and 100× magnification showed the presence of epidermis, stomata, and chlorophyll. The result of microscopic study of Banto simplicia at 40× magnification and 100× magnification showed the presence of epidermis and chlorophyll.

Uji Aktivitas Ekstrak Alang-Alang (Imperata cylindrica L) sebagai Peluruh Kalsium Batu Ginjal secara In Vitro Istnaini Reiza Fatimah; Mahfuzun Bone; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 11 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kidney stones are a disease caused by existence urine sediment in the kidneys and urinary tract which clog the urinary tract so that when urinating it causes pain. One alternative to be used to treat kidney stone disease is traditional treatment using herbal plants that are widespread in Indonesia. The plants that is widespread in Indonesia, Imperata that grow wild in forests, fields, lawns and roadside in sunny dry areas. The research was aimed to find secondary metabolites and activity of Imperata extract ethanol on calcium solubility of kidney stones. Kidney stones from the reaction between calcium chloride and potassium oxalate. The extract was obtained from the maceration process using 96% ethanol solvent. The test of secondary metabolites by adding chemical reagents to the extract and activity test by making 3 series of extract concentrations, namely 1%, 3% and 5%. 100 mg kidney stones were inserted in the extract solution than incubated for 3 hours (370C). The filtrate was measured dissolved calcium levels using a UV-Visible spectrophotometer at ? 499 nm. The result show that Imperata positive containing flavonoids, alkaloids, tanins, steroids and triterpenoids, and have an effect in dissolving kidney stone calcium in vitro where the best concentration of ethanol extract of Imperata is 5% concentration with dissolved calcium levels of 301,450 ppm.

Studi Literatur: Efek Pemberian Obat Herbal terhadap Penderita COVID-19 Cyntia Bella Anggraini; Dewi Mayasari; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

COVID-19 is a disease that has never been identified in the human body before and is highly contagious. Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Due to the high number of casualties due to COVID-19, many ways have been done to treat the outbreak of this virus. One of them is the use of herbal medicines from plants that are believed to cure people with COVID-19. This study aims to describe the impact of herbal medicine on patients with Covid-19. Literature search using PubMed, ScienceDirect and Google Scholar. Literature search strategy using keywords Traditional Chinese medicine, Chinese medicine, Chinese herbal medicine, COVID-19, new coronavirus pneumonia, SARS-CoV-2. The results obtained, namely from 10 literature show that herbal treatment can reduce symptoms of Covid-19 and boost the immune system. The use of herbal medicines for COVID-19 needs to be considered carefully to support the limited scientific data.

Co-Authors Abdul Mutalib Adinda Niti Meilaningrum Aditya Fridayanti Amalia Srikurniawati Ameilia Rachmadianty Andi Tenri Kawareng Angga Cipta Narsa Aprilia Wulandari Arsyik Ibrahim Asri Wido Mukti Asti Rahayu Asti Rahayu Aulia Alfath Rahmawati Ayida Mawarda Cindy Puspita Perdana Cyntia Bella Anggraini Dewi Mayasari Dewi Perwito Sari Dewi Rahmawati Dhea Amanda Sabilla Fauzi Enggar Wijayanti Erwin Samsul Febrina Mahmudah Fidhia Rara Lande Fika Aryati Fika Aryati Fitriani Miranda Ganjar Firmansyah Hadi Kuncoro Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hanny Chynthia Vehrawati Herman Herman Hidayatunnikmah, Nina Intan Ayu Kusuma Pramushinta Irmayanti Irwan Islamudin Ahmad Istnaini Reiza Fatimah Jaka Fadraersada Junaidi Khotib Khusnul Khatimah Rukhayyah Lisna Meylina M. Arifuddin M. Khalid Akbar Mahfuzun Bone Martalena Ramli Maulidya Maulidya Miranda Aurora Pratiwi Mirhansyah Ardana Mirhansyah Ardana Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Faisal Muhammad Yusuf Mutiara Citra Refordayanti Nanda Uswatun Hasanah Novita Eka Kartab Putri Novita Eka Kartab Putri Nur Amiiroh Isyraqi Nur Aprilianti Nur Mita Nurul Fitriani Prisma Trida Hardani Prisma Trida Hardani Purbosari, Ira R. Ukun M.S. Soedjanaatmadja Rahmadani, Agung Ridha Siti Ruhama Rifaldy Rahmadillah Riska Novianti Rizal Adi Saputra Rizki Noor Amelia Sari, Dewi Perwito Shofia Siza Maulidia Sri Lestari Sukardiman Tanti Dwi Gunawati Tri Woro Widyanti Triani Yastuti Kuling Wa Ode Rungaya Ningsih Komala Wahyu Trimadianti Wahyu Widayat Yoni Miftahun Nafsiyah Agustin Yuspian Nur Yustika Rahayu Zuhrotun Nafisah

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