Advancements in machine learning have enabled the development of more accurate and efficient health prediction models. This study aims to improve diabetes prediction performance using the Support Vector Machine (SVM) model optimized with the Hybrid Gradient Descent Gray Wolf Optimizer (HGD-GWO) method. SVM is a robust machine learning algorithm for classification and regression. Still, its performance depends significantly on selecting appropriate hyperparameters such as regularization (C), kernel coefficient (γ), and polynomial kernel degree (d). The HGD-GWO method synergizes gradient descent for local optimization and the Gray Wolf Optimizer for global solution exploration. Using the Pima Indians Diabetes dataset, the process includes normalization, hyperparameter optimization, data division, and performance evaluation using accuracy, precision, recall, and F1-score metrics. The optimized SVM achieved an accuracy of 81.17%, with precision, recall, and F1-score values of 75.00%, 57.45%, and 65.06%, respectively, at a data ratio of 80%:20%. These findings highlight the potential of HGD-GWO in enhancing predictive models, particularly for early diabetes detection.